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99,167 grants found
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Neurological Disorders in HIV-1 Infection
ABSTRACT There is a high incidence of neurological disorders (HAND) in middle-aged people living with HIV infection (PLWH). To date, the molecular causes for diverse array of HAND...
Innovative Tools to Expand HIV Self-Testing and Long-Acting Injectables for HIV Treatment and Prevention Among Commercial Minibus Drivers (I-TEST LAIs)
Abstract: Commercial minibus drivers constitute a large social network of highly mobile men who work long and demanding hours, are at increased risk for HIV, and have limited time...
AmbassADDOrs for Health: Maintaining youth-friendly HIV prevention services to young women through drug vendors
SUMMARY Adolescent girls and young women (AGYW; ages 15-24) in sub-Saharan Africa face the dual threats of HIV infection and unintended pregnancy that severely undermine their long...
Optimizing mobile interventions to overcome stigma and promote HIV prevention among Thai young transgender women
Transgender women (TGW), particularly young TGW (ages 18-29), are among the fastest growing HIV+ populations worldwide, with HIV prevalence rates of 15-28%. Thailand has the highes...
CHAMPION - Combining HIV And Stimulant Prevention and Treatment Interventions Optimized for HIV-Negative MSM
PROJECT SUMMARY MSM remain disparately impacted by HIV, with only 35% of US MSM with indications for PrEP having ever used PrEP. Meth use is an established and persistent driver of...
SCH: Multi-modal Biosensing and Predictive Analytics for Continuous Monitoring of Mobility and Cognition in an Aging Population
PROJECT SUMMARY (See instructions): Declines in cognitive and motor function are early harbingers of pending Alzheimer's Disease and related dementia (AD/ADRD). New technologi...
Molecular mechanisms controlling skin heterogeneity
This project summary pertains to the Supplement. Different regions of the skin vary in their characteristics such as thickness, pigmentation, innervation, and presence, size and de...
Preclinical Assessment of a Compliance Matched Biopolymer Vascular Graft - Diversity Supplement
PROJECT ABSTRACT Cardiovascular diseases (CVDs) stand as the primary contributor to global mortality and play a significant role in diminishing the quality of life. The growing inc...
RUNX3 in Vascular Wall Remodeling-Diversity Supplements
Project Summary Vascular smooth muscle cell (VSMC) phenotypic modulation, a phenotypic switch from a differentiated contractile phenotype to a proliferative phenotype, contributes...
Corticolimbic circuitry in adaptive stress coping behavior and subsequent alcohol drinking
Project Summary Individuals with post-traumatic stress disorder (PTSD) consume alcohol as an attempt to alleviate symptoms, which can increase the risk of developing a drinking pro...
Longitudinal transdisciplinary Neuropalliative care Support for Patients with Severe Stroke and their Families
PROJECT SUMMARY/ABSTRACT: Stroke is not just an event but a chronic illness with tremendous impact. Every year, 5 million people die of stroke, and another 5 million are left with...
Early Type 2 Diabetes Detection with AI-Analysis of Skeletal Muscle Ultrasound and Mechanistic Evaluations
Worldwide approximately 232 million or 50% of people with type 2 diabetes mellitus (T2D) are undiagnosed. Furthermore, 81% with prediabetes (PreD), more than 77 million in the Unit...
ExPEC Vaccine Development
PROJECT SUMMARY The evolution of bacterial resistance to antibiotics is precipitating a medical crisis that will cause millions of deaths and cost trillions in dollars. A major bac...
Deciphering How Bacterial Surface Properties Influence Social Behaviors
Project Summary Cystic fibrosis (CF) is a genetic disease that results in persistent and chronic lung infections which reduce lung function over time. Pseudomonas aeruginosa (Pa),...
Virus-host interactions for a cure against HBV
Project Summary Hepatitis B virus (HBV) infections affect the lives of more than 296 million people who are chronically infected with HBV and are at risk of developing liver cirrho...
Harnessing Cells from Human Milk; Linking Lactation to Metabolism
Project Summary: Breastfeeding has been shown to protect mothers and their children from metabolic disease later in life. However, maternal obesity and diabetes independently predi...
Pain and Nutrition in Dementia and Alzheimer's-2 (PANDA-2)
PROJECT ABSTRACT/SUMMARY Growing evidence suggests the presence of dysregulated pain modulation in older adults, and affect which may heighten age-associated risk for chronic pain....
Integrating low-cost and versatile technologies to achieve colorimetric HCV and HIV detection from whole blood
PROJECT ABSTRACT In the United States alone, over 2 million people live with active hepatitis C virus (HCV) infections, and up to 140,000 new infections occur each year. Since 2013...
The Progressive Supranuclear Palsy Clinical Trial Platform (PTP)
PROJECT SUMMARY / ABSTRACT Progressive Supranuclear Palsy (PSP) is a severe neurodegenerative disease of aging that usually leads to death within 5-7-years of diagnosis. There are...
Examining the Association between Residential Ambient Air Pollution and Pediatric Hospitalization due to Acute Respiratory Disease Across New York State
Project Summary Ambient air pollution is a major pediatric public health concern due to its ubiquity and increased exposure patternsaffiliated with climate change over the next dec...