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The Role of Chemical Exposures in Alzheimer's Disease (AD) and its Trajectory
It has become increasingly clear that environmental exposures, the genome, gut microbiome, diet, and lifestyle all affect an individual’s metabolic state contributing to brain heal...
Development of Measure(s) of Financial Hardship and Health Disparities among Individuals Living with ADRD and Their Family Caregivers
Abstract The treatment and care of Alzheimer's disease and related dementias (ADRD) place a huge burden on individuals, families, and healthcare systems. The estimated lifetim...
Diabetes Brain and Cognitive Development-Type 1 (DBCD-T1)
ABSTRACT Glucose is the most important source of energy for proper brain development and functioning; therefore, any imbalance in glucose is associated with changes in neurodevelop...
NonInvasive Virtual Biopsy for Determining Bone Turnover in Chronic Kidney Disease
PROJECT SUMMARY / ABSTRACT Extremes of bone turnover are common in patients with chronic kidney disease (CKD), a population with exceptionally high fracture risk. Medical managemen...
Advancing ADPKD Treatment with GLP-1RA: A Study of Glucagon-Like Peptide-1 Receptor Agonists' Efficacy, Safety, and Mechanism
Project Summary Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder that leads to kidney failure. The only approved treatment to decelerate kidney d...
Emerging role of oral spirochetes to promote neuroinflammation and dysfunction
Periodontitis is a common chronic inflammatory condition of the tooth-supporting tissue, affecting up 50% of the population and two-thirds of the elderly in the United States. Prog...
Simultaneous two-photon imaging and two-photon manipulation of neural activity in freely behaving mice
Simultaneous two-photon imaging and two-photon manipulation of neural activity in freely- behaving mice The ability to record and manipulate neural activity in freely-behaving mice...
Impact of mast cell heterogeneity on Osteoarthritis
SUMMARY Osteoarthritis (OA) is a highly prevalent and debilitating disease, affecting over 27 million people in the US. Its risk factors include aging, joint injury, obesity, and t...
Estrogen and Mechanisms of Psychotic-like Experiences in the Transition to Adolescence
PROJECT SUMMARY Biological females develop psychotic disorders later than males. One leading theory that explains this phenomenon is the estrogen hypothesis, which proposes that ri...
ADEPT-ICU: Attenuating Depression with Internet Cognitive Behavioral Therapy (CBT) to Slow Cognitive Decline in Older Intensive Care Unit (ICU) Survivors
PROJECT SUMMARY/ABSTRACT Alzheimer’s disease and related dementias (ADRD) affect 47 million people worldwide with an annual global cost of $818 billion. The risk of developing ADRD...
Leveraging Project ECHO for improved cervical cancer screening in Ethiopia: An implementation study of integrated HPV selfsampling in HIV care centers
PROJECT ABSTRACT Each year, more than 500,000 women are diagnosed with cervical cancer (CxCa), a preventable cancer caused by human papillomavirus (HPV) that disproportionately bur...
Development of the novel mu-opioid receptor antagonist methocinnamox (MCAM) for preventing relapse and overdose
PROJECT SUMMARY/ABSTRACT In response to PAR-22-202 “Grand Opportunity in Medications Development for Substance-Use Disorders (U01 Clinical Trial Optional),” this revised applicatio...
Effects of social isolation and loneliness during early life on neurocognitive development and addiction
Project Summary Social isolation (SI) and loneliness are associated with adverse health outcomes and are serious public health risks throughout life. In early life, SI has well kno...
Accelerated Brachytherapy Forward Chemoradiation Therapy (ABC-RT) for Cervical Cancer
PROJECT SUMMARY Survival from cervical cancer is stagnating in the United States. Despite many intervening clinical trials, the standard of care (SOC) definitive chemoradiation the...
Using Virtual Reality to help develop discrepancy and elicit change talk in brief motivational interventions for heavy drinking young adults
Project Summary/Abstract Alcohol use is the leading risk factor for premature death among young adults globally. Brief motivational interventions (BMIs) can help young adults reduc...
Microphysiological joint-on-chip platform for the study of arthritic diseases
PROJECT SUMMARY / ABSTRACT The objective of this proposal is to establish a new microphysiological ‘joint-on-chip’ system, with structural biomimicry and biomechanical function, th...
Autism Spectrum Disorders and Auditory System Deficits: Role of Neuronal and Immune System Dysfunction
ABSTRACT Hearing impairment in children with autism spectrum disorders (ASDs) may contribute to core ASD symptoms by interfering with language development and communication. The nu...
Implementation of Neuromuscular Electrical Stimulation after Total Knee Arthroplasty
PROJECT SUMMARY / ABSTRACT Total Knee Arthroplasty (TKA) reduces pain and disability caused by knee osteoarthritis, but the surgery results in substantial trauma to the knee. This...
Study of Biological and Radiographic Biomarkers and Association with Ancestry and Survival Disparities in Oral Cavity Squamous Cell Carcinoma Using AI Approaches
ABSTRACT Oral cavity squamous cell carcinoma (OSCC) is a complex and aggressive disease that requires multidisciplinary care and has a poor prognosis at advanced stages. Moreover,...
Natural history and validation of surrogate biomarkers and patient-reported outcomes for SJIA-LD
Project Summary / Abstract Chronic lung disease in children with systemic juvenile idiopathic arthritis (SJIA-LD) is a life-threatening disorder which is increasing in incidence an...