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99,167 grants found
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Sperm chromatin structure and remodeling during spermiogenesis and fertilization
PROJECT SUMMARY Genetic inheritance material of a eukaryotic organism (DNA) is stored in chromosomes. Understanding of cellular activities in normal development and disease require...
Does Learning Require Calcium-Dependent Myelin Remodeling?
PROJECT SUMMARY/ABSTRACT: Myelin is essential for rapid and precise nerve signaling, and its loss in diseases like multiple sclerosis causes profound disability. Classically, myeli...
MOTS-C, APOE, and Alzheimer's disease
The 4 allele of apolipoprotein E (APOE4) is associated with accelerated aging and mortality as well as increased vulnerability to Alzheimer’s disease (AD). Although the causal lin...
Determining the Origins and Vulnerabilities of Pediatric Treatment-Induced Gliomas
ABSTRACT Pediatric treatment-induced high-grade glioma (HGG), also known as radiation-induced glioma (RIG), is an incurable secondary cancerous brain tumor that affects children wh...
Using integral equations to capture spatiotemporal relations in the brain
Project Summary Medical recordings contain dynamical information that can provide quantitative pathological fingerprints that prove crucial to correct diagnostic. Brain recordings...
Investigation of the Flavin Dependent Thymidylate Synthase enzyme as a potential antimicrobial target
PROJECT SUMMARY With the increase in antibiotic resistance bacterial infections there is an urgent need for novel antimicrobial agents that target alternative cellular pathways. On...
Integrative Approaches to Study Cell-Type-Specific Protein Dysregulation in Human Diseases
Project Summary/Abstract Complex diseases are driven by intricate interactions among various cell types present at the disease sites. Recent advancements in single-cell RNA sequenc...
Mechanistic insights into the kinetics of Fc receptor-mediated placental antibody transfer to optimize maternal vaccine strategies
ABSTRACT Infants are vulnerable to infection due to their tolerogenic immune phenotype and limited adaptive immune memory, which has limited the success of newborn vaccines. Trans-...
A Clinical Trial Readiness Study of Patient Reported Outcome Measures in Thrombotic Thrombocytopenic Purpura (TTP)
PROJECT SUMMARY/ABSTRACT With a prevalence of 10 cases per million, immune thrombotic thrombocytopenic purpura (iTTP) is classified as a rare disease. Yet, it has significant human...
Ribcage-abdominal movement asynchrony in persons with Parkinsons disease
Project Summary Respiratory data from five existing human subject datasets will be merged in order to comprehensively examine the dynamic and coordinated movements of the chest wal...
Targeting mitochondrial calcium to eradicate leukemia-initiating cells
SUMMARY The goal of this project is to develop strategies for the eradication of leukemia-initiating cells (LICs) in AML patients who have received initial therapy with venetoclax...
Repurposing FDA-approved drugs for the treatment of osteoarthritis using high-throughput screening in microphysiological models
Abstract: Osteoarthritis (OA) is a painful and disabling joint disorder affecting more than 30 million Americans. Current treatments for OA are primarily to relieve pain and mainta...
Optimizing a Remote-based Physical Activity Intervention for Adults with Total Knee Replacement
Over 4 million adults are living with a total knee replacement (TKR); however, most do not achieve recommended physical activity levels. To date, physical activity interventions fo...
Regulation of distal basal cells in terminal and respiratory airway regeneration
PROJECT SUMMARY Distal (or small) airways including the terminal and respiratory bronchioles (TRB) are the sites of damage in several lung diseases. Pathologies of small airway les...
Defining the role of single-cell heterogeneity in bacterial vaginosis
PROJECT SUMMARY/ABSTRACT A major challenge in bacterial pathogenesis is the prevention and treatment of polymicrobial diseases, as microbe-microbe interactions alter the initiation...
Prenatal exposure to cannabis and child cardiometabolic health outcomes
Cannabis use among pregnant people is on the rise. This trend is likely to be continue, especially among people who are younger or those live in states where cannabis is legal. Yet...
Effect of a technology-based collaborative care model on persistent hypertension and preventive careattendance among postpartum people with hypertensive disorders of pregnancy
PROJECT SUMMARY/ABSTRACT Uncontrolled hypertensive disorders of pregnancy (HDP) are a major source of maternal mortality. National guidelines recommend blood pressure (BP) measurem...
Structure-function studies of DELE1-mediated activation of the integrated stress response
ABSTRACT Protein homeostasis (proteostasis) is tightly regulated by an intricate network of finely tuned cellular pathways. Among the pathways required for responding to internal o...
Developing an Inclusive Measure of Financial Hardship for People Living with Dementia and their Care Contributors
PROJECT SUMMARY The number of individuals with Alzheimer’s disease or Alzheimer’s disease-related dementias (AD/ADRD) in the U.S. is projected to increase to 9 million by 2030 (fro...
Impact of Grin2b/GluN2B disruption on dopaminergic function and related behavior
PROJECT SUMMARY The gene that encodes the NMDA-GluN2B subunit (GRIN2B) is one of the top 10 genes implicated by de novo, gene-disrupting single nucleotide variants (SNVs) in autism...