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99,167 grants found
Showing 281 – 300 of 99,167 grants
The Development, Implementation, and Evaluation of a Social Engagement Support System
PROJECT SUMMARY Social drivers of health (SDoH) are the largest factors affecting our health and wellbeing but are difficult for healthcare systems to address. The lack of healthy...
Influence of Social Media, Social Networks, and Misinformation on Vaccine Acceptance Among Black and Latinx Individuals
Abstract One of the most recent and significant public health problems deals with addressing vaccine hesitancy and mis/disinformation. As new types of vaccines become effective and...
Promoting healthy interbirth intervals through post-partum reproductive health services
PROJECT SUMMARY The World Health Organization recommends postpartum family planning (PPFP) for birth spacing and prevention of maternal and newborn morbidity and mortality. Unfortu...
AI-assisted Annotation of Minimally Invasive Surgical Video for Building Information-Rich Datasets and Data-Efficient Learning Systems
ABSTRACT Minimally invasive surgery (MIS) has gained popularity in recent years by offering increased manipulation dexter- ity in hard-to-reach areas through small incisions, there...
The role of placental macrophages in cytomegalovirus infection at the maternal-fetal interface
Human cytomegalovirus (HCMV) is the most common cause of congenital infection, affecting an estimated 0.6- 0.7% of newborns in the USA. Depending on the timing of maternal primary...
Asthma Self-Management Behaviors and Cognitive Autonomy: Developing an Adolescent Questionnaire
Background and Rationale: Asthma is a substantial public health problem with adolescents having substantial asthma-related morbidity. Adolescence is a critical phase of transition...
Improving Artificial Intelligence Readiness of RNA Motif Data for Structure Analysis and Modeling
PROJECT SUMMARY / ABSTRACT The rapid advancement of artificial intelligence (AI) and machine learning (ML) has led to significant breakthroughs in molecular structure modeling, par...
Integrating the reference pangenome with biobank-scale data for complex trait analysis
Project summary The human reference pangenome, which represents a collection of genome sequences in a single data structure, has the potential to transform human genetics applicati...
Exploring Best Communication Practices for Shared Decision Making in Older Adults Considering Major Colorectal Surgery
The older adult population (OAs; e.g., ≥65-years old) is projected to almost double between 2012 and 2050 in the United States. This population already disproportionately utilizes...
Targeting Amino Acid Metabolism in Glioblastoma
ABSTRACT Glioblastomas rank among the most lethal of all human cancers. Current therapy includes maximal surgical resection, followed by combined radiotherapy and oral chemotherapy...
Comparing a Novel Telehealth-enabled Hybrid Cardiac Rehabilitation Program to Clinic-based Cardiac Rehabilitation for Improving Patient Engagement, Functional Outcomes, and Health Equity after ACS
PROJECT ABSTRACT Cardiac rehabilitation (CR)—which involves exercise training, patient education, and health behavior modification—is a comprehensive intervention traditionally del...
Protecting endogenous recovery from the "infectious insult" in Spinal Cord Injury
Abstract Acquired infections after spinal cord injury (SCI) constitute the main cause of death in patients. For those that survive, acute pneumonia has been associated with signifi...
Social, Genomic, and Epigenomic Drivers of Clopidogrel Response in Puerto Ricans
Project Summary Pharmacogenomics has shown itself to be on the leading edge of clinical translatability in genomic medicine, with findings that are currently implemented across the...
Strategies to Improve Communication Structure and Quality in Low-resource Childhood Cancer Hospitals
PROJECT SUMMARY/ABSTRACT Children with cancer in low-resource settings face a survival rate of only 20%. Clinical deterioration, defined as the worsening of patient status that req...
Dance-based Avenues to Advance Nonpharmacologic treatment of Chemotherapy Effects (DAANCE): a multicenter trial
Project Abstract: Breast cancer (BC) is the second most frequently diagnosed cancer among women (second only to skin cancer)[11,12] and up to 80% of survivors experience chemothera...
Advanced analytics for uncovering virus dynamics and functional potential
Project Summary/Abstract The human virome, i.e. the collection of viruses found in or on humans, is a complex set of viral communities whose diversity is only now starting to be ex...
Establishing laboratory methods for quantitative recovery of diverse DNA and RNA viral sequences from human biosamples
PROJECT SUMMARY The widespread adoption of inaccurate and biased methods has impeded effective analysis and stymied comprehensive understanding of the composition and dynamics of t...
Viral MEM: Viral Enrichment and Precise Stochastic Quantification with Microbial Context Preservation for Rigorous Virome Analysis of Challenging Human Samples
PROJECT SUMMARY Overview. This U01 proposal is dedicated to advancing the Human Virome Project (HVP) by addressing several key objectives outlined in RFA-RM-23-018 NOFO. The projec...
Interdisciplinary investigation of functional asymmetry and topological restructuring in mitochondrial networks during cellular aging
Project Summary Age- and function-based positioning of mitochondria plays a critical and conserved role in cellular differentiation and aging from yeast to humans. Evidence suggest...
Role of right ventricular passive remodeling in ventricular-arterial uncoupling in pulmonary hypertension
SUMMARY Right ventricular (RV) dysfunction and the inability of the RV contractility to keep up with increased afterload, or ventricular-arterial (V-A) uncoupling, in pulmonary hyp...