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99,167 grants found
Showing 281 – 300 of 99,167 grants
Platform technologies for scalable highly multiplexed proteomic phenotyping of the brain
The complexity of the mammalian brain is unparalleled by any other organs, and understanding its cellular composition and their brain-wide organization is essential to understand t...
Indiana Clinical and Translational Sciences Institute
PROJECT SUMMARY/ABSTRACT The Indiana Clinical and Translational Sciences Institute (Indiana CTSI) was created in 2008 as a statewide partnership to accelerate clinical and transl...
CTSA UM1 Program at University of Utah
ABSTRACT The vision of the Utah Clinical & Translational Science Institute (CTSI) is to strategically and ethically develop and apply generalizable and reproducible clinical and...
Delaney AIDS Research Enterprise to Cure HIV
PROJECT SUMMARY/ABSTRACT The goals of the DARE Collaboratory are to develop a viable combination regimen that reduces the rebound- competent HIV/SIV reservoir during antiretrovir...
Delaney AIDS Research Enterprise to Cure HIV
PROJECT SUMMARY/ABSTRACT The goals of the DARE Collaboratory are to develop a viable combination regimen that reduces the rebound- competent HIV/SIV reservoir during antiretrovir...
The role of 24-hour activity cycles in preserving cognitive function and preventing Alzheimer's disease and related dementias
ABSTRACT Alzheimer’s disease and related dementias (ADRD) are the 6th leading cause of death in the U.S and is prevalent in ~6 million U.S. adults. Without effective prevention s...
Delaney AIDS Research Enterprise to Cure HIV
PROJECT SUMMARY/ABSTRACT The goals of the DARE Collaboratory are to develop a viable combination regimen that reduces the rebound- competent HIV/SIV reservoir during antiretrovir...
Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney Collaboratory
ABSTRACT The immediate establishment of the latent HIV-1 reservoir in resting memory CD4+ T cells precludes HIV-1 cure, compelling ART for a lifetime in children. The mission of...
Indiana Clinical and Translational Sciences Institute
PROJECT SUMMARY/ABSTRACT The Indiana Clinical and Translational Sciences Institute (Indiana CTSI) was created in 2008 as a statewide partnership to accelerate clinical and transl...
CTSA UM1 Program at University of Utah
ABSTRACT The vision of the Utah Clinical & Translational Science Institute (CTSI) is to strategically and ethically develop and apply generalizable and reproducible clinical and...
Vascular-immune mechanisms of cerebral amyloid angiopathy and Alzheimer's pathology
Cognitive decline in the aging brain is driven by overlapping neurodegenerative and cerebrovascular pathologies. Over 80% of Alzheimer's disease (AD) patients co-present with cereb...
Enterprise for Research and Advocacy to Stop and Eradicate HIV (ERASE-HIV)
Abstract The presence of a reservoir of cells harbouring integrated, replication-competent virus that persists under long- term, fully suppressive antiretroviral therapy (ART) an...
CVL-354, a kappa opioid receptor antagonist for treatment of opioid use disorder, withdrawal and relapse
PROJECT SUMMARY Kappa opioid receptors (KOR) are expressed in brain areas that control reward, motivation, and anxiety. Dynorphin (DYN), an endogenous KOR agonist controls KOR acti...
Multi-morbidity 3-City Alzheimer's Disease EHR Study (M3AD Study)
The overall goal of our proposal is to place patients impacted by Alzheimer’s Disease (AD) and Related Dementia (AD/ADRD), rather than the disease, at the center of the research i...
The Rhythm Evaluation for Anticoagulation with Continuous Monitoring of Atrial Fibrillation Trial (REACT-AF)
Project Summary / Abstract Purpose: The Rhythm Evaluation for AntiCoagulaTion with Continuous Monitoring of Atrial Fibrillation (REACT AF) clinical trial will compare the efficac...
REACH: Research Enterprise to Advance a Cure for HIV
PROJECT SUMMARY/ABSTRACT Despite the success of standard antiretroviral therapy (ART), the need for an HIV cure remains compelling, both to improve the lives of PWH and to bring...
Development of Lofexidine as a First-line Non-Opioid Pharmacologic Treatment for Neonatal Opioid Withdrawal Syndrome
PROJECT SUMMARY: An alarming increase in the rate of opioid abuse among the general population has resulted in a public health emergency since 2017. The striking rise in opioid use...
Development of a Potent and Selective Nav1.8 inhibitor for the Treatment of Acute and Chronic Pain with the Goal of Reducing Opioid Use and Preventing Opioid Use Disorders
PROJECT SUMMARY Voltage-gated sodium ion channels (NaVs) are required for the transmission of electrical signals along pain sensing neurons. While a number of NaV isoforms are ex...
HOPE - HIV Obstruction by Programmed Epigenetics
PROJECT SUMMARY/ABSTACT After 40 years, a cure for people living with HIV (PLWH) remains both elusive and one of NIAID/NIH’s highest priorities. Rebound-competent latent reservoi...
HOPE - HIV Obstruction by Programmed Epigenetics
PROJECT SUMMARY/ABSTACT After 40 years, a cure for people living with HIV (PLWH) remains both elusive and one of NIAID/NIH?s highest priorities. Rebound-competent latent reservoir...