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99,167 grants found
Showing 2,941 – 2,960 of 99,167 grants
Rewired Metabolism and Immunosuppression in MYCN-driven Neuroblastoma
PROJECT SUMMARY Amplification of the oncogene MYCN drives high-risk progressive disease, resistance to therapy, and a poor overall survival rate below 45% for high-risk neuroblasto...
Advancing VR-based attentional bias as a biomarker for tobacco use disorder
PROJECT SUMMARY There are few effective treatment options for smoking cessation. The identification and validation of reliable biomarkers for tobacco use disorder has the potential...
Evolution of the Chicago Classification: Bridging Physiology and Mechanics
PROJECT SUMMARY Swallowing difficulties are extremely common and result in substantial morbidity, reduction in the quality of life, and mortality related to malnutrition and compli...
Development of Polygenic Scores for Medication Response in Diverse Populations
Polygenic scores (PS) represent an exciting translational application of genomic information that can mitigate some short comings of traditional genetic approaches, and which have...
Mobile Health for Migrant Health (mHealth-4-Mhealth): Assessing the Effectiveness of Implementing an mHealth Program to Increase COVID-19 Testing and Treatment Among Rural Migrant Families
PROJECT SUMMARY/ABSTRACT Migrant agricultural workers and their families face formidable challenges in accessing COVID-19 testing, treatment, and preventive measures due to geograp...
Mechanism of intestinal TET3-mediated DNA oxidation and transcriptional regulation
PROJECT SUMMARY DNA methylation dynamics in mammals are an integral component of the epigenetic regulatory machinery. Methylated DNA functions as a repressive mark for gene express...
Impact of HIV co-infections and comorbidities on circadian rhythm in the liver
Project Summary HIV-associated comorbidities, co-infections, and complications (CCCs) can exacerbate the health burden in people living with HIV (PLWH). Using innovative cell cultu...
L-type calcium channels in Alzheimer’s disease pathophysiology
Abstract The calcium hypothesis of Alzheimer’s disease (AD) links calcium dysregulation and the amyloidogenic pathway to cognitive dysfunction and tau pathology in AD. Calcium dysr...
Development of Attentional Biases for Affective Cues in Infants of Mothers with Depression
PROJECT SUMMARY/ABSTRACT The link between depression in mothers and their children is well established, and there is growing evidence thatchildren’s biased attention to facial disp...
Mechanics of Brain Folding in Human Infants Evaluated Using MRI
Abstract In human brain development, the third trimester represents a critical period of cortical expansion, folding, and white matter organization. Deviations from the normal deve...
Role of FBW7 in cystic diseases of the kidney
Polycystic Kidney Disease is the common denominator in several phenotypically diverse genetic conditions of the kidney. These diseases include Autosomal Dominant Polycystic Kidney...
RUNX proteins define opposing fates in the male germline
PROJECT SUMMARY / ABSTRACT Compelling evidence from human epidemiological studies and model systems indicate that many adult diseases can be traced to deficits far earlier in devel...
Elucidating the roles of adipocyte KAT8 in lipoatrophy and systemic insulin resistance
Project Summary: Adipocytes are highly specialized cells that have a number of functions including lipid storage, insulin sensitivity, and significant endocrine capabilities. Obesi...
Pathogenic Germline Mutations in Barrett's Esophagus
PROJECT SUMMARY: Esophageal adenocarcinoma (EAC) remain among the most lethal cancers, with a 5- year survival rate of ~20%. Present in 1-6% of the general population, Barrett’s Es...
Engaging communities to develop and evaluate communication strategies for HIV vaccine and prevention uptake among Black women in the Southern US
Project Summary This proposal addresses NIMH’s call for HIV vaccine preparedness and “HIV vaccine-related” communication research (Notice of Special Interest NOT-MH-21-105). Though...
Clinical trial of omalizumab for allergen sensitized and exposed individuals with COPD
Project Summary Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease with significant variation in disease manifestation, progression, and outcomes. There is inc...
High- and low-level computations for coordination of orofacial motor actions
Overall - Abstract High- and low-level computations for coordination of orofacial motor actions Neuronal circuits in the brainstem integrate control of life-sustaining motor action...
Confluence of high- and low-level signaling for the control of orofacial rhythmic motor actions
Project 1. Abstract Confluence of high- and low-level signaling for the control of orofacial rhythmic motor actions Orofacial actions are nominally comprised of two components: a r...
The shape, movement, and signals of active sensors: Modeling the biomechanics of deformable orofacial organs
Project 2. Abstract The shape, movement, and signals of active sensors: Modeling the neuronal control and biomechanics of deformable orofacial organs (Golomb as lead; all PIs contr...
Identifying brainstem oscillators and other low-level mechanisms controlling tongue and jaw movements
Abstract- Project 3 Identifying brainstem oscillators and other low-level mechanisms controlling tongue and jaw movements All vertebrate species depend on feeding for survival. Lik...