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99,167 grants found
Showing 2,921 – 2,940 of 99,167 grants
A Pilot Study of Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients (SLEEP-BOOST)
PROJECT SUMMARY/ABSTRACT Sleep disorders, including insomnia, are likely present in up to a third of older patients before surgery, but most remain untreated. Increasing evidence s...
Epigenetic deregulation of osteoblasts promotes age related clonality in hematopoietic cells
Abstract The bone marrow stroma and especially osteoblasts, are critical regulators of the development of hematological myeloid malignancies, actively promoting their development o...
BRAIN CONNECTS: A Scalable Automated Proofreading Framework for Connectomics
Summary Generating synapse-resolution maps or connectomes of the brain are crucial to understanding the neural basis of behavior, and can provide key insights into the onset, progr...
Homeostatic modeling of functional neuroimaging data in humans: a novel methodology to obtain brain maps of tissue pCO2, pO2 and pH in aging
Project Summary Altered cerebrovascular health is strongly associated with aging. PET and MRI studies have found age dependent reductions in resting cerebral blood flow (CBF) and n...
Gpr68 modulation of myofibroblast dynamics during tendon healing
Following injury, tendon heals via a fibrotic scar-mediated process. This fibrotic response impairs restoration of tendon structure and function, and there are currently no pharmac...
Identifying non-human primate models for specific human microbiome traits
Abstract: The gut microbiota is increasingly recognized as an important contributor to a range of human physiological processes and is attracting increasing attention as a dynamic...
Roles of epidermal integrin α3β1 in age-dependent changes during cutaneous wound healing
Project Summary Even without comorbidities associated with aging, wound healing in healthy elderly people (>65) is delayed, posing a high risk of infection. However, mechanisms...
Development of an Organoid-Derived Exosome Product for the Treatment of Osteoarthritis
Summary/Abstract Osteoarthritis (OA) is a chronic debilitating joint disease, affecting over 32 million people in the USA with an economic impact of $550 billion/year. OA is charac...
Small molecule stimulation of lubricin for treatment of post-traumatic osteoarthritis
Project Summary/Abstract The prevalence and cost of osteoarthritis is astounding, with total osteoarthritis-attributable medical expenditures and lost earnings surpassing $300 bill...
Care for Persons with Dementia in Medicare Advantage and Traditional Medicare: Family Spillovers and Disparities
Project Summary Medicare beneficiaries with Alzheimer's Disease and Related Dementias (ADRD) typically require significant amounts of formal and informal healthcare. These tre...
Sensory Aging, Late-Life Wellbeing, and ADRD Research Infrastructure to Catalyze Practice and Policy
ABSTRACT The goal of this 5-year research infrastructure development grant (R61/R33) is to substantially strengthen a small but successful collaborative, international network – th...
Exerkines and the heterogeneity of peripheral and cerebral vascular adaptations to exercise training with aging in women and men
PROJECT SUMMARY/ABSTRACT Aging is the primary risk factor for cardiovascular diseases (CVD) and Alzheimer's disease and its related dementias (ADRD),1, 2 due in part to advers...
Role of Hyaluronan in IL-13-mediated COVID-19 Pathology
Project Summary Introduction: IL-13 is elevated in patients with COVID-19, in mice infected with SARS-CoV-2 IL-13 neutralization improved survival and decreased pulmonary depositio...
Mitochondrial Function and Multiomics in Aging-related Disease: Identifying Novel Biomarkers and Causal Relationships
Mitochondria play an essential role in cellular function and impact human health through varied mechanisms, including energy metabolism, cell signaling, and apoptosis. We have prev...
Equity for Parent Presence and Participation in Caregiving in the NICU
PROJECT SUMMARY/ABSTRACT While some barriers and facilitators to parent presence and participation (PPP) in the neonatal intensive care unit (NICU) have been identified, comprehens...
Non-invasive infrared light therapy and medical device to treat spinal cord injury
Currently, there are no approved interventions that significantly attenuate the acute injury and inflammatory response in the initial early (< 24 h) phase following SCI which le...
Validation of NAD+ measurements for human clinical studies: multi-method inter-laboratory standardization
Recent years have seen a surge of interest in the role of NAD in human disease and whether increasing NAD with supplements such as nicotinamide riboside (NR) or nicotinamide mononu...
ATP1B3: novel regulator of T cell-mediated immunity
Project Summary T cells are key components of immune responses to infection and in autoimmunity. Like all cells, they require ion channels and transporters for their function. Chan...
Phase 1 First in Human Trial to Assess Safety and Tolerability of the Novel ACK1 Inhibitor (R)-9b in Patients with Prostate Cancer
Abstract Prostate cancer (PC) is one of the leading cause of cancer deaths among American men. Advanced PC patients often receive androgen deprivation therapy, but, the recalcitran...
Avoiding Cardiovascular Complications in Liver Transplantation through Novel Studies (ACCT NOW) in Hypertension
PROJECT SUMMARY One in three liver transplant recipients experiences a cardiovascular event within one year of transplant because of immunosuppression medications and a high preval...