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99,167 grants found
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Modulating spinal interoceptive pathways to evaluate their role and therapeutic potential in MDD symptomatic domains
Project summary Spinal interoceptive pathways (SIPs) convey bodily signals to an interoceptive system in the brain and their dysregulation is linked to major depressive disorder (M...
Restoration of reduced nitric oxide bioavailability in Preeclampsia
PROJECT SUMMARY: Our lab in collaboration with Akkadian Therapeutics, Inc. (AKTX), have demonstrated the beneficial effects of the novel catalytic radical scavenger and nitric oxid...
Racialized inequities in birth outcomes and maternal health following childbirth: the role of maternal early-life disadvantage, adolescent contexts, and pre-pregnancy stress
PROJECT SUMMARY/ABSTRACT: This proposed study assesses how social contextual stressors over the maternal pre-pregnancy life course contribute to the unacceptably wide racialized in...
RNA Modification Changes in Alcohol-Associated Liver Disease
Abstract. Alcohol consumption is a predominant etiological factor in the pathogenesis of chronic liver diseases. The progressive nature of alcohol-associated liver disease (ALD) ha...
Mindfulness to Enhance Cognitive Health in Latinx Older Adults at Risk for Alzheimer's Disease
PROJECT ABSTRACT As the world ages, Alzheimer’s Disease (AD) and related dementias are quickly becoming some of the most pernicious and burdensome diseases around the globe. This b...
Implementation and pilot testing of a culturally centered CBT protocol for suicidal behaviors among youth in Mexico City
PROJECT SUMMARY/ABSTRACT The risks of ideating, suicide attempt (SA), and dying by suicide have never been greater for Mexican teens. In the past two decades, the rates of suicidal...
Persistent Effects of Dietary Protein Restriction on Protein Motivation and Underlying Physiology
Project Summary It is often assumed that animals rapidly adapt behaviorally and physiologically to nutritional challenges and that adaptations to such challenges carry implications...
Epigenetic Age and Patient Outcomes after Severe Traumatic Brain Injury
ABSTRACT Aging is a risk factor for many chronic conditions including Alzheimer’s disease (AD) and Alzheimer’s disease related dementias (ADRD) and impacts patient outcomes after t...
The influence of asthma on walking in older adults: brain predictors, medication adherence and asthma control
The increased prevalence of asthma among older adults and its associations with multiple adverse health outcomes including poor cognition are of significant public health concern....
Planning a childhood sJOgren disease Use of Randomized N-of-1 Evaluation of therapY JOURNEY
Project Summary/Abstract: Childhood Sjögren's disease (cSD) is a rare autoimmune disease that primarily affects the glands, leading to salivary and lacrimal gland inflammation...
Innate sensing of M. tuberculosis by alveolar macrophages
PROJECT SUMMARY Mycobacterium tuberculosis (Mtb), the causative agent of Tuberculosis (TB) is one of the leading causes of death globally by a single infectious agent. There contin...
Neurocognitive Effects of Late-Childhood Iron Deficiency Anemia
PROJECT SUMMARY Iron deficiency anemia (IDA) experienced in early childhood causes long-lasting negative consequences on brain development, connectivity and cognition. Given the hi...
A longitudinal, randomized-controlled experiment of healthy food policies in online retail settings
PROJECT SUMMARY Unhealthy diets significantly contribute to major preventable chronic diseases including type 2 diabetes, obesity, heart disease and stroke, which disproportionally...
Striatal Dopamine Signals Underlying Valence-Dependent Learning
Project Summary Real-life learning occurs through feedback in the form of reward or punishment. Dopamine is a key molecule in the brain known to play a central role in learning fro...
Gene Editing for Hemophilia A Treatment Using Lipid Nanoparticles
PROJECT SUMMARY The goal of this project is to combine the technology of lipid nanoparticles (LNPs) and CRISPR/Cas9 gene editing tools to correct the mutant factor VIII (FVIII) gen...
Elucidating Regulation of Cell Fate Specification in Human Cortical Development to Understand Etiology of Neurodevelopment Disorders
PROJECT SUMMARY The human brain has an expanded cortex compared to its closest relatives, and this outer layer of the brain provides humans with complex functions including integra...
Engaging African American Couples in the Management of Obstructive Sleep Apnea
ABSTRACT Obstructive sleep apnea (OSA) affects 26% of adults over age 30 and is associated with significant morbidity and mortality. At the time of presentation, African American h...
Mitochondria in eosinophilic esophagitis pathogenesis
Project Summary Eosinophilic esophagitis (EoE) is a chronic food allergen- and immune-mediated disease that exerts a significant clinical and financial burden worldwide. Interleuki...
Investigating Mechanisms of Complement Mediated Synaptic Removal
Project Summary Alzheimer’s disease (AD) is a neurodegenerative disorder that culminates in neurodegeneration resulting in cognitive decline. The pathological correlate most tightl...
Explore the involvement of tRNA in the pathophysiology of antisynthetase syndrome
Project Summary Antisynthetase syndrome (ASSD) is a chronic autoimmune disorder characterized by myositis and interstitial lung disease (ILD). A key feature of ASSD is the presence...