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99,167 grants found
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REIT Investments in Nursing Homes and the Quality of End of Life Care for Residents with Alzheimer's Disease and Related Dementias
PROJECT SUMMARY/ABSTRACT Alzheimer's disease and related dementias (ADRD) affect 5.5 million people in the US and account for $305 billion in health care spending annually. Ne...
Do Hospices Specializing in Long-Term Care Settings Provide Better Care to Beneficiaries with Alzheimer's and Related Dementia?
PROJECT SUMMARY Hospice programs have been historically less experienced in caring for beneficiaries with Alzheimer’s and Related Dementia (ADRD), although ADRD represents one of t...
SHP2's Regulation of the Bone Marrow Stroma and Hematopoietic Crosstalk
(PLEASE KEEP IN WORD, DO NOT PDF) (Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.)It has been...
Environmental risk factors linked to TDP-43 proteinopathies
ABSTRACT Most neurodegenerative diseases are sporadic with unknown etiology that likely stems from the interaction between genetics and the environment, the latter of which continu...
Molecular effects of cannabinoids on the Blood Brain Barrier in HIV-infected brain
Molecular effects of cannabinoids on the Blood Brain Barrier in HIV-infected brain Infection with the human immunodeficiency virus (HIV) causes significant disease morbidity in the...
Engineering promiscuous enzymes for synthesis of biological building blocks
The use of enzymes in synthesis has had an enormous impact on the development of bioactive compounds, as they can perform transformations with unparalleled selectivity at a low cos...
Signaling, Sensing, and Enzymatic Roles of Disordered Selenoproteins
PROJECT SUMMARY Selenoproteins are prominently engaged in the integrated cellular response to stress. Here we focus on the ER- bound membrane proteins selenoprotein K (selenok) and...
The potential benefits of autophagy activator TFEB in opioid use disorder in mice
PROJECT SUMMARY In the United States, the prevalence of opioid use and opioid use disorder (OUD) more than doubled in recent years. There has been an increase in opioid-related ove...
The role of paracrine growth factor signaling in thymus function and age-associated dysfunction
The thymus is the primary site of T lymphocyte development, where mutually inductive signaling between lymphoid progenitors and thymic epithelial cells (TECs) directs the progenito...
Developing a Music Listening mHealth Intervention for Stress Reduction in Early Recovery
Project Summary Alcohol use in the Unites States is a public health crisis that costs the U.S. health care system $249 billion annually. However, only about 10% of individuals with...
Calculating the Components of Work of Breathing in Neonates with Bronchopulmonary Dysplasia
Project Summary Neonates can now survive premature birth from as early as 22 weeks’ gestation, but often suffer from bron- chopulmonary dysplasia (BPD) – chronic lung disease of pr...
Impact of wearable biofeedback for the rehabilitation and tele-rehabilitation of neurogenic dysphagia
PROJECT SUMMARY/ABSTRACT Oropharyngeal swallowing disorders (a.k.a. dysphagia) are among the most common and dangerous manifestations of many neurologic conditions. Critically, dys...
Targeting Nonalcoholic Fatty Liver Disease during the reproductive period to improve women's health outcomes
Nonalcoholic fatty liver disease (NAFLD), and its progressive form, nonalcoholic steatohepatitis (NASH), is the leading cause of cirrhosis and liver transplantation in women, yet i...
Novel 3D Quantitative Dynamic MRI to Characterize Obstructive Sleep Apnea
SUMMARY An estimated 30-70% of obstructive sleep apnea (OSA) patients are intolerant to first-line continuous positive airway pressure (CPAP) therapy for a variety of reasons. A va...
Effect of physical rehabilitation on molecular markers of frailty in heart failure
PROJECT SUMMARY/ABSTRACT Heart failure (HF) with preserved ejection fraction (HFpEF) is characterized by functional impairment, is highly prevalent in older persons, causes substan...
BRAIN CONNECTS: Scalable Approaches for Bidirectional Brain-wide Trans-Neuronal Connectivity Mapping of Defined Cell Types
PROJECT SUMMARY A major goal in modern neuroscience is to comprehensively map circuits of synaptically connected cell types throughout the mammalian brain. The key technological ga...
Biophysical properties of lymph nodes in aging
Summary Aging reduces our bodies’ ability to respond to pathogens and vaccines. This is thought to at least in part be due to impaired functions of adaptive immune cells, which are...
Synthesis and Evaluation of a Bivalent Glycoconjugate Vaccine for Prevention of Infection with Acinetobacter baumannii
The proposed work will involve the synthesis and evaluation of glycoconjugates designed to trigger adaptive immune responses that provide protection against infection by the bacter...
A Multi-Site Feasibility Trial of Embedded Emergency Department Physical Therapy for Back Pain
PROJECT SUMMARY Low back pain affects nearly half of all Americans per year and accounts for nearly three million annual emergency department (ED) visits. In nearly two thirds of t...
Defining Novel Roles of Platelets and Macrophages in the Healing of Abdominal Aortic Aneurysm
ABSTRACT (Project Summary) Rupture of abdominal aortic aneurysms (AAA) leads to sudden death in 15,000 to 30,000 men and women over the age of 65 each year in the US, and this numb...