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99,167 grants found
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SCLC Model Generation and Therapeutic Analysis
Project Summary The laboratory mouse plays a central role in the preclinical development of new therapeutic strategies and through the application of transgenic technology has prov...
Advanced Imaging and Computational Approaches
The Advanced Microscopy and Computational Approaches Core (Core C) will provide advanced imaging and computational approaches to support this Program Project in elucidating the mol...
Unmasking neuromodulatory control of locomotion
Project Summary Neuromodulators including dopamine and serotonin have profound effects on spinal circuits for locomotion. A wealth of pharmacological manipulations has shown that d...
Hydroxyproline Dehydrogenase Inhibitors for the Treatment of Primary Hyperoxaluria
PROJECT SUMMARY: The breakdown of hydroxyproline, a component of collagen within our bodies and in the meat that we consume, is a significant contributor to glyoxylate and oxalate...
Neural Mechanisms of Social Information Processing
Project Summary To feel, remember and act in a social environment, incoming social stimuli must be processed and represented. Recent advances have revealed several routes of social...
Developing strategies for using DNA data to assist family reunifications across child development stages
PROJECT SUMMARY Family separations due to disasters, armed conflict, and migration affect millions, are expected to increase, and damage children’s health across the lifecourse. Gi...
Wirelessly recording and manipulating neural activity to study the sensorimotor dynamics of free behavior
In our daily lives, we explore and learn about the world around us through body movement. For instance, to find your keys in your bag, you use your fingers to touch each object in...
Comprehensive MR Fingerprinting for Infants and Young Children at Risk for Developmental Delays.
Abstract Neuroimaging of infants and young children is increasingly used to monitor brain development that can ultimately influence long-term health and behavioral outcomes. Our re...
Understanding the role of bedrock, settlement patterns, and water quality in human health equity
Project Summary Neither populations nor health outcomes are spread evenly across the natural environment. Due to historical patterns of selective land settlement, natural resource...
Modulating the Stem Cell Niche Set Point to Improve Skeletal Muscle Regeneration
Abstract Human pluripotent stem cells (hPSCs) transplantation therapies offer an appealing avenue to combat skeletal muscle diseases. Directed differentiation of hPSCs to skeletal...
Intravesical genome editing in urothelium
This proposal is submitted in response to PAR-23-119: “Catalytic Tool and Technology Development in Kidney, Urologic, and Hematologic Diseases (R21 Clinical Trial Not Allowed)”. Th...
Molecular determinants of oxidative stress in Salmonella pathogenesis
ABSTRACT: Almost two billion people worldwide become ill with diarrhea annually, and ~700,000 die. Nontyphoidal Salmonella, such as Typhimurium, cause roughly 180 million diarrheal...
Evaluation of Bioenergetic Supplements in Treatment-Resistant Depression, Cognitive Dysfunction and Anxiety
Major depressive disorder (MDD) and anxiety are linked to brain deficits in the bioenergetic molecules creatine (CR) and acetyl-L carnitine (ALC), nutritional supplements which sho...
Multilevel determinants of prenatal syphilis screening policy implementation
PROJECT SUMMARY/ABSTRACT This R03 proposal aims to explore the multilevel determinants of the implementation of prenatal syphilis screening policies into clinical practice among ob...
The Interaction Between the Thyroid Axis and Brown Adipose Tissue in Humans
This project is designed to evaluate the relationship between the intra-cellular thyroid hormone (TH) levels and brown adipose tissue (BAT) activity, transcriptome and cellular com...
Intergenerational disadvantage and pediatric health disparities in acute respiratory illness and diarrhea
PROJECT SUMMARY Global literature underscores that certain children and families are more likely to experience persistent social and economic disadvantages often determined by thei...
Novel oxidative pathway targets microglia in Alzheimer's disease
Abstract Alzheimer's disease is the most common dementia characterized by progressive cognitive decline. By estimates, Alzheimer's disease affects more than one-third of...
Analysis of immunologic mechanisms in patients with chronic lung disease after acute COVID infection
Project Summary/Abstract As of February 8, 2023 more than 102.7 million cases of SARS-CoV-2 infection leading to COVID-19 disease have occurred in the United States. Besides the ac...
Phosphoarginine-linked protein quality control and stress responses in mycobacteria
ABSTRACT Antibiotics are a cornerstone of modern medicine, but antibiotic resistance threatens the effectiveness of our existing antibacterial arsenal. This phenomenon poses an acu...
Long-term Endotypes of Prematurity Associated Respiratory Disease (LEOPARD)
Project Summary Infants born before 28 weeks of gestation are at high risk for morbidity that often persists through childhood in the form of asthma, alveolar disease, or pulmonary...