Browse All Grants
99,167 grants found
Showing 2,841 – 2,860 of 99,167 grants
Mechanisms for environmental microplastics-enhanced colorectal tumor progression
Project Summary In response to the Notice of Special Interest (NOSI) NOT-ES-23-002, our research addresses the urgent concern of escalating plastic pollution. Despite numerous repo...
Biomarker Assessment of Adherence and Effectiveness in a Randomized Controlled Trial to Reduce Added Sugar Intake in Adolescents
PROJECT ABSTRACT Added sugar (AS) is a critically important dietary target for intervention in adolescents; it contains excess calories with no nutritional value and is independent...
Role of Long Non-coding RNAs in the Ovulatory Process
TITLE: Role of Long non-coding RNAs in the Ovulatory Process. ABSTRACT Women’s reproductive health plays a pivotal role in regulating overall well-being. Unfortunately, about 12% o...
Regulating Establishment of the Mammalian Ovarian Reserve
Project Summary Approximately 12% of couples are infertile and 1% of the female population worldwide experiences primary ovarian insufficiency (POI) which results from a reduction...
From Perceptions to Behaviors: A Comprehensive Approach to Examine the Impact of Public Health Communication Messaging about the Continuum of Risk for Tobacco Products
PROJECT SUMMARY Effective communication strategies are urgently needed to convey the relative risks of tobacco products accurately among adults who currently use combustible tobacc...
PHARMACOKINETICS AND PHARMACOGENOMICS OF DOLUTEGRAVIR-BASED ANTIRETROVIRAL THERAPY IN YOUNG PEOPLE LIVING WITH HIV IN GHANA (PHARMA-YOUNG-HIV)
PROJECT SUMMARY The World Health Organization (WHO) in 2019 recommended dolutegravir (DTG)-based antiretroviral therapy (ART) as the preferred treatment regimen for all persons liv...
Liposomal Amphotericin B and Flucytosine Antifungal Strategies for Talaromycosis (LAmB-FAST)
ABSTRACT Talaromycosis is caused by the dimorphic fungus Talaromyces marneffei (Tm) endemic in Southeast Asia where it is a leading the cause of death among patients with advanced...
Assessing Internalized Health-Related Stigma in Spanish-Speaking Latino Adults
PROJECT SUMMARY/ABSTRACT Stigma adversely affects mental and physical health. Societal devaluation or mistreatment from others can lead to internalization of stigma (i.e., self-sti...
Developing a Structurally-Motivated Model of Coronary Microcirculation Mechanics and Hemodynamics
Project Summary The myocardium relies on a continuous supply of oxygen from a complex system of blood vessels that make up the coronary circulation. Despite its importance, the cor...
HIV Vaccine Trials Network Laboratory Center - B-Cell and Molecular Assay Multi-year Supplement
Abstract Accelerating B Cell and Antibody Molecular, Functional and Structural Analysis in Sequential bnAb-inducing Env Immunogen Clinical Trials Development of an effective HIV va...
Regulation of mycobacterial adaptive mistranslation
PROJECT SUMMARY Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) uses regulation of specific translation error rates – mistranslation – to survive a varie...
Functional significance of plasma cell infiltrates of human cardiac allograft vasculopathy
PROJECT SUMMARY Cardiac allograft vasculopathy (CAV) is presently the leading cause of morbidity and mortality following heart transplantation. While the pathophysiology of CAV is...
Antibody recognition of paramyxovirus surface proteins
While vaccines are available for SARS-CoV-2, influenza virus, and RSV, and our laboratory has advanced mAbs and vaccines for hMPV, there has been a lack of research on parainfluenz...
Neural Circuits for Stress-Impaired Extinction Learning
PROJECT SUMMARY Clinical disorders of fear and anxiety, including trauma- and stressor-related disorders, represent an enormous public health burden. Unfortunately, cognitive-behav...
Neural Substrates of Contextual Memory in Fear Extinction
PROJECT SUMMARY Therapeutic interventions, such as exposure therapy, reduce pathological fear in patients with anxiety disorders. Extinction is a fundamental form of learning that...
Maternal Stress, Human Milk Composition, and Neurodevelopmental and Feeding Outcomes
PROJECT SUMMARY/ABSTRACT Preterm birth and the hospitalization of infants in the neonatal intensive care unit (NICU) are well-documented as stressful events for mothers. Although m...
Determining the mechanism and impact of streptococcal RaS-RiPPs on the human oral microbiome
PROJECT SUMMARY The human oral microbiome is home to a unique group of bacteria with the ability to affect the overall health of the human host: Streptococci spp. This group is inv...
Mechanisms of Replication Stress Tolerance in SCLC
PROJECT 2 SUMMARY Exacerbating replication stress is a powerful means to kill cancer cells through mitotic catastrophe due to intolerable levels of DNA replication-associated lesio...
Repair Mechanisms of Replication fork Lesions in SCLC
PROJECT SUMMARY This project will investigate the specific mechanisms of DNA lesions that are generated in SCLC during treatment and lead to response or resistance to therapy. This...
Impact of recurrent genetic alterations on SCLC subtypes and therapeutic response
Project Summary Small cell lung cancer (SCLC) is a highly aggressive malignancy with high heterogeneity and few available treatment options. SCLC cells are of highly plastic enabli...