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99,167 grants found
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Social Determinants of Health Research Project
SUMMARY– THE COMMUNITY GATEWAY TO HEALTH EQUITY STUDY (SDOH STUDY) The Community Gateway to Health Equity Study, our SDOH study, aims to investigate the impact of a multi-level app...
Community Responsive Project
SUMMARY – COMMUNITY RESPONSIVE PROJECTS PROGRAM Although academics are well-meaning in designing studies they believe will improve health equity, they often do not have relevant li...
Jointly modeling the effects of evolutionary processes on genomic variation
PROJECT SUMMARY Understanding what shapes patterns of genetic diversity in natural populations is an inherently challenging problem. Despite the challenges, studying variation in D...
Cell Based Immunomodulation to Suppress Lung Inflammation and Promote Repair
Acute respiratory distress syndrome (ARDS) affects over 300,000 Americans annually with a 43% mortality rate. Inflammation plays a key pathogenic role in mortality, particularly in...
The Role of TREK-1 potassium channels in ARDS
PROJECT SUMMARY: Significance: To date, no targeted therapies exist that prevent or improve the outcomes of patients with Acute Respiratory Distress Syndrome (ARDS). Despite an inc...
Oogenic JNK in gonadotoxic chemotherapy-induced primary ovarian insufficiency
PROJECT SUMMARY The advances in cancer survival rates greatly enhance the awareness of side effects of cancer therapy and long- term life quality after cancer. Primary ovarian insu...
Impact of HIV on the human alveolar environment drivingthe early events of Mycobacterium tuberculosis infection
ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), reaches the lung alveoli where it is in contact with the alveolar mucosa. This mucosal surface is lined by...
Caregiving Influences on Attention and Executive Function in Children Born Very Preterm
PROJECT SUMMARY / ABSTRACT Children born very preterm are at increased risk for deficits in attention and executive function, two domains that are strongly implicated in long-term...
Metabolic enforcement of selection in anti-DNA B cells vs. antigen-specific B cells
PROJECT SUMMARY/ABSTRACT Autoantibodies initiate inflammation and tissue injury in patients with autoimmune disease. Antibody specificity (for both foreign- and self-antigens) is d...
Investigating and Targeting Replication Stress in Small Cell Lung Cancer
PROJECT SUMMARY/DESCRIPTION Small-cell lung cancer (SCLC), accounting for about 15% of all cases of lung cancer worldwide, is the most lethal form of lung cancer. Despite an initia...
Administrative Core
CORE A SUMMARY/DESCRIPTION Core A is critical to the operation of this program project, and has three major aims. In Aim 1, core A will initiate and organize regular communication...
Replication Stress Sensing and Signaling Defects in SCLC
PROJECT SUMMARY The underlying mechanisms that account for initial sensitivity to of SCLC to chemotherapy followed by profound therapeutic resistance are just beginning to be eluci...
Identification and optimization of medical countermeasures for phosgene inhalation injuries
Summary Phosgene gas has been used as a terrorist weapon, in warfare and has injured many Americans in transportation or industrial accidents. Phosgene targets the lungs, causing s...
The impact of maternal cyanotoxin ingestion on the development and function of the stress axis in offspring
The impact of maternal cyanotoxin ingestion on the development and function of the stress axis in offspring. Anthropogenic activities and global warming have increased water eutrop...
Discovery of Novel Cyanotoxins by Detection of Their Native Fluorescence and Unique MS/MS Fragments, and Determination of Their Toxicities
Abstract Cyanopeptides are not easily identifiable and quantified in water during harmful cyanobacterial blooms (cHABs) because they are present as multiple congeners and a few of...
Roles for desmsomes in mRNA localization and translational regulation
Abstract Desmosomes are cell adhesion structures that provide mechanical stability to the epidermis and other tissues. Their canonical function is to link cells to the underlying i...
Roles of TIMELESS in oncogene-induced senescence and oncogenic transformation
PROJECT SUMMARY Oncogenic stimuli in early cancerous lesions, such as driven by RAS mutations, triggers oncogene-induced senescence (OIS), which acts as a barrier to prevent malign...
Molecular Determinants of Zinc Regulation of Mammalian Sperm
Zinc is the most abundant trace metal in the body, and the highest zinc concentrations are found in semen. Human semen is enriched with 1-3 mM zinc, a 100-fold higher concentration...
Cellular and molecular coordinators of large-scale bone repair
ABSTRACT The challenge of repairing extensive bone injuries remains an unmet clinical challenge. Our research is dedicated to exploring a novel mouse model of large-scale bone rege...
REST-MED12 Pathways in the Regulation of Estrogen - Progesterone Sensitivity in Uterine Leiomyoma
Project Summary/Abstract Uterine fibroids (leiomyomas) are benign smooth muscle cell (SMC) tumors of the myometrium. Leiomyomas represent the most frequent clinical indication for...