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99,167 grants found
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Celiac and inflammatory bowel diseases: functional post-GWAS approach
ABSTRACT Celiac disease (CeD) is one of the most prevalent yet understudied gastrointestinal disorders in the U.S., and there is a critical need to understand genotype-phenotype re...
Preventing Intimate Partner Violence Among Teens Who Are Pregnant or Parenting
PROJECT SUMMARY/ABSTRACT As many as two-thirds of teens who are pregnant or parenting have been the victims or perpetrators of physical intimate partner violence (IPV) and there is...
Semantic Development
Project Summary The proposed research is designed to illuminate how semantic organization emerges in the course of development, and how it contributes to the fundamentally human ab...
Understanding The Role Of FSHR Oligomerization And Trafficking In Transducing Age-dependent Changes In FSH Glycoforms
Project Summary/Abstract Although ovarian aging is a natural physiological process, cessation of ovarian function at midlife increases susceptibility to the development of co-morbi...
Improving outcomes in HIV-associated opportunistic infections using CNS pharmacokinetics and pharmacodynamics
ABSTRACT Mortality from cryptococcal and TB-meningitis in individuals with HIV is unacceptably high and better therapeutics are needed. The future landscape of treatment against th...
Addressing the paradox of poor outcomes despite successful recanalization in stroke
Project Summary In recent years, endovascular stroke therapy (EVT) has emerged as a highly effective treatment for large vessel occlusions (LVO) acute ischemic stroke (AIS). Howeve...
CHAMP-V + LAW: A program to prevent youth violence by addressing upstream structural determinants through community health worker and civil legal aid interventions
PROJECT ABSTRACT Violence is the leading cause of mortality among US children. In Chicago, violence disproportionately affects children of color on the South and West sides, with s...
T Cells and IL-9 Signaling at the Maternal-Fetal Interface in Preterm Labor and Birth
PROJECT SUMMARY Approximately 70% of preterm births are preceded by preterm labor, which is primarily associated with non- infectious etiologies. However, little is known about the...
Sjögren’s Team for Accelerating Medicines Partnership (STAMP)
ABSTRACT Sjögren’s Disease (SjD, formerly known as Sjögren’s syndrome) is a common systemic autoimmune rheumatic disorder second only to rheumatoid arthritis in prevalence. It prim...
Mechanisms of Genome Stability
Precise duplication of our genome and appropriate cellular response to genotoxic stress is critical to maintaining genome stability. Origin Recognition Complex (ORC, composed of si...
Phage Therapy for Recurrent UTIs in Kidney Transplant Recipients
PROJECT SUMMARY/ ABSTRACT Recurrent urinary tract infections (rUTI) are a common problem in kidney transplant recipients (KTR), especially women, and lead to serious consequences –...
Beyond Urea Kinetics: Balancing Tradeoffs in Dialyzer Design for the Next 50 Years
The 548,000 Americans who rely on dialysis to stave off death from kidney failure suffer from malnutrition, inflammation, immune defects, and vastly increased incidence of coronary...
GLP-1R agonist immune targets in lean and obesity-associated asthma
Project Summary Multiple preclinical and clinical studies show that glucagon-like peptide-1 receptor (GLP-1R) agonists, FDA approved agents used in type 2 diabetes, obesity, and ca...
Long-read genome sequencing for the discovery of highly penetrant variation in rare diseases
Project Summary/Abstract The goal of this proposal is to improve upon current methods to identify genetic contributors to rare diseases, especially neurodevelopmental disorders (ND...
The role of the microbiome and other host related factors in determining urine oxalate levels
Oxalate is involved in the pathophysiology of kidney stones (KS) and chronic kidney disease (CKD), which, respectively, affect more than 9% and 15% of the adult US population. High...
CNS Senescence and Immunopathology in Lethal POWV Infection of Aged Mice
Powassan virus (POWV) is a neurovirulent tick-borne flavivirus (FV) emerging in the N.E. US. POWV causes a 10% fatal encephalitis resulting in severe long-term neurologic damage in...
Meningeal Immunity and Viral Neuropathogenesis
SUMMARY Emerging and re-emerging neurotropic viruses, including flaviviruses and alphaviruses, generally cause fever, malaise, and related symptoms. However, in some patients, thes...
The Mass Partnership for Community-Engaged Cancer Control Equity
ABSTRACT The Massachusetts Partnership for Community-Engaged Cancer Control Equity (Mass PCECCE) builds on a robust partnership between the Harvard T.H. Chan School of Public Healt...
Admin-Core
SUMMARY - ADMINISTRATIVE CORE The Administrative Core of the Massachusetts Partnership for Community-Engaged Cancer Control Equity (Mass PCECCE is designed to provide scientific an...
Research Measures Method and Data Management Core
SUMMARY – RESEARCH METHODS, MEASURES, AND DATA MANAGEMENT CORE The Research Methods, Measures, and Data Management (RMMDM) Core of the proposed Massachusetts Partnership for Commun...