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99,167 grants found
Showing 2,781 – 2,800 of 99,167 grants
Addressing mental health and medication adherence among MSM in South Africa
PROJECT SUMMARY In this R34 application (PAR-23-060, Formative and Pilot Intervention Research to Optimize HIV Prevention and Care Continuum Outcomes), we propose to develop and pi...
Neocortical microarchitecture of executive function using large-scale intracranial electrophysiology
PROJECT SUMMARY Advancing our understanding of the neural basis of human cognition is limited due to the rarity of intracranial recordings in humans, and the inherent inadequacy of...
Rhythmic pace-making of nephron induction for renal replacement tissues
PROJECT SUMMARY The goal of this proposal is to study and control rhythmic nephron induction for kidney replacement tissues. Kidney organoids derived from human induced pluripotent...
Sexually dimorphic regulation of bone mass by the X-linked histone modifier KDM5C
PROJECT SUMMARY/ABSTRACT Women are disproportionally susceptible to osteoporosis with generally poorer treatment outcomes. For decades, research regarding this difference was focus...
Significance of Epac signaling in renal Na+handling and hypertension
PROJECT SUMMARY Kidneys play a central role in regulation of water-salt balance with excessive renal Na+ conservation being tightly associated with hypertension. The existing diure...
Links between the neonatal connectome and dimensions of social development
ABSTRACT Functional brain network characteristics reflect both genetic and environmental influences on brain development during fetal and postnatal periods. Alterations in network...
Development of novel genetic tools for the study of type IV collagens
PROJECT SUMMARY The broad goal of our research is to understand the biological functions of type IV collagens in the extracellular matrix and determine the mechanisms by which they...
A multidimensional investigation of social support for transgender and nonbinary people and its impacts on health and well-being: Measurement development using community engagement
PROJECT SUMMARY/ABSTRACT Trans and nonbinary (TNB) individuals experience mental and physical health disparities compared to cisgender peers, such as higher rates of depression and...
Building a Collaborative Research and Training Platform for HIV and Rheumatic and Musculoskeletal Diseases in Uganda
PROJECT SUMMARY/ABSTRACT Sub-Saharan Africa bears the greatest burden of the global human immunodeficiency virus (HIV) epidemic. Uganda is no exception, with over 1.5 million perso...
The mechanisms of MEIG1 complex in mammalian spermiogenesis and fertilization
Natural fertilization and embryo development require heathy spermatozoa to carry male genetic material to fertilize the egg. During the final phase of spermatogenesis, the spermati...
Early interventions at ART initiation to reduce the HIV-1 reservoir and enhance adaptive immune responses
Increasing efforts are being made to understand whether early intervention after HIV-1 infection can enable long- term viral control and reduction of the viral reservoir through th...
How Distinct Age-Associated B Cell Subsets Can Protect the Aged from Influenza
ABSTRACT: How Distinct Age-Associated B Cell Subsets Can Protect the Aged from Influenza. With age, the generation of T follicular helpers from naive CD4 T cells, and of germinal c...
KIBRA-induced biomechanical changes and therapeutic targeting in podocytes
Despite recent progress in the identification of mediators of podocyte injury, mechanisms underlying podocyte loss remain poorly understood, and cell-specific therapy is lacking. O...
Molecular Modeling of the DR domain of an HIV restriction factor PSGL-1
Project Summary/Abstract Studying the anti-HIV mechanisms of restriction factors is central to understanding virus-host interaction and for developing novel therapeutics. Recently,...
Preclinical Testing of Potential Next-generation Antischistosomal Compounds
PROJECT SUMMARY / ABSTRACT Human schistosomiasis is a disease caused by species of the genus Schistosoma, which globally affects over 200 million people. The major species affectin...
Acute and chronic effects of GLP-1R agonism on NPY/AgRP neuronal activity
Glucagon-like peptide 1 (GLP-1)-based therapeutics have profound effects on body weight and blood glucose management. GLP-1 cells are located in both the periphery and the caudal m...
Treatment outcome requirements for disease prevention in Chagas disease
Abstract Infection with the protozoan parasite Trypanosoma cruzi is generally controlled but often not eliminated by host immune responses. In humans and many other hosts, this per...
Respiratory Distress in Sheep with Hypophosphatasia: Etiology, Functional Consequences and Rescue
Project Summary This new R21 application “Respiratory Distress in Sheep with Hypophosphatasia: Etiology, Functional Consequences and Rescue” will provide novel insights into the ro...
Functional relevance of C. trachomatis trp operon polymorphism
PROJECT SUMMARY The trp operon in several bacterial species is regulated at multiple levels that include transcription, translation, post-translation, and enzyme activity. The rece...
The Role of Kisspeptin/Neurokinin B/Dynorphin (KNDy) neurons in an animal model of polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a leading cause of female infertility worldwide. The syndrome is diagnosed by ovarian symptoms, including cystic ovaries, disrupted or absent me...