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99,167 grants found
Showing 261 – 280 of 99,167 grants
User-friendly open-source pipeline for anatomically precise analysis of single-trial M/EEG
PROJECT SUMMARY Magneto- and electroencephalography (M/EEG) measure human brain activity non-invasively, using sensors placed on or above the head, with millisecond accuracy, and h...
Drinking water salinity in a hot-dry environment: Hydration, kidney function, and blood pressure
PROJECT SUMMARY/ABSTRACT The increasing salinity of groundwater is a key emerging global environmental health risk factor for hundreds of millions of adults, including in the Unite...
Dissecting the role of mPFC dynorphin circuits in the modulation of different pain states
PROJECT SUMMARY The goal of this work is to identify pain-induced adaptations in the prefrontal cortical dynorphin / kappa-opioid receptor system and the role this system plays in...
Investigation of cold plasma for healing alcohol-induced tissue injury
Abstract: Binge drinking of alcohol beverages hinders tissue repair and amplifies the susceptibility to infection. The prevalence as well as the risks associated with binge drinkin...
Development of a Culturally Adapted Digital Health Application for Older Hispanics with Type 2 Diabetes
PROJECT SUMMARY Poor health literacy, medication non-adherence, and lack of interventions easily delivered by healthcare providers negatively impact health outcomes in Hispanic pat...
Phase behavior of proteins in crowded environments
PROJECT SUMMARY Current research proposes protein phase separation as a key mechanism underlying the formation of liquid-like biomolecular condensates, which play an integral role...
Carver Genomic Research Center (CGRC)-Building Next Generation Genomic Data Scientist in Rural Alabama
Project Summary The establishment of a Diversity Center for Genomic Research at Tuskegee University is driven by a comprehensive objective: to advance, support and maintain researc...
Effects of Developmental Alcohol and Nicotine E-Cigarette Co-Exposure on Physiological Measures and Behavioral Development
PROJECT SUMMARY: Alcohol and nicotine are the two most commonly consumed licit drugs among pregnant people. Although the potential consequences of prenatal alcohol exposure at diff...
Interleukin-6 signaling, lung injury, and post-TB lung disease in TB-HIV
ABSTRACT Tuberculosis (TB) is among the leading infectious killers worldwide with over 10 million new cases and 1.5 million deaths each year. Pulmonary TB, the most common form of...
RaceCAR-M immunotherapy for cancer and beyond
Cellular immunotherapies like Chimeric Antigen Receptor T cells (CAR-T) extend the lives of cancer patients who are otherwise out of options. These therapies represent a leap forwa...
Nuclear ATP citrate lyase and ischemia/reperfusion injury in steatotic liver
Abstract Non-alcoholic fatty liver disease represents a group of conditions associated with excessive lipid accumulation in hepatocytes because of long-term energy surplus. This di...
Understanding multilevel predictors affecting family formation among sexual and gender minority couples
PROJECT SUMMARY Family formation plans (e.g., whether/when to have children) vary by micro-level factors like sociodemographics (age, race/ethnicity) and individual- and couple-lev...
A Prospective Randomized Controlled Trial to Evaluate the Impact of Treatment of Asymptomatic Bacteriuria on Low Birth Weight
PROJECT SUMMARY/ABSTRACT Asymptomatic bacteriuria (AB) in pregnancy has been associated with an increased incidence of neonatal morbidity including preterm birth and low birth weig...
Determining the Proximal and Temporal Effects of Alcohol and Sexual Communication on Intimate Partner Sexual Violence among Sexual Minority and Heterosexual Couples
PROJECT ABSTRACT Up to 33% of women and 16% of men report experiencing intimate partner sexual violence (IPSV), and sexual minority (SM) individuals are 2.5 times more likely to ex...
Exploring genomic and cellular determinants of gene therapy durability
PROJECT SUMMARY Since the identification of disease-causing genes, the promise of gene correction seemed out of reach for decades. New delivery vehicles and gene-editing tools have...
Imaging deep-tissue morphogenesis at whole-organism scales
Project Summary/Abstract Morphogenesis of biological tissue is a rich and complex process in which coordinated interplay between molecular and mechanical stimuli progressively shap...
Actívatexto: Advancing smoking cessation and physical activity among Latinos
PROJECT SUMMARY Overcoming the burden of tobacco use among Latinos demands innovative, effective, accessible, culturally appropriate, and community-engaged solutions. Over the past...
Flexible dual-duration multi-wavelength fiber sources for nonlinear and multimodal imaging
The goal of this research program is to develop robust and flexible dual-duration, multi- wavelength fiber sources of light for nonlinear and multimodal imaging with orders of magn...
Cellular Mechanisms of Age-Associated Cortical Bone Remodeling
Abstract In the United States, 8.2 million women and 2.0 million men age 50 and above have osteoporosis. Moreover, half of all women and one quarter of men are projected to suffer...
Development of EP2 Receptor Antagonist to Treat Alzheimer's Disease
Lay Summary Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Currently, about 6.5 million Americans are living with AD. Alzheimer’s and other dementia...