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99,167 grants found
Showing 261 – 280 of 99,167 grants
Immunologic and Virologic Basis of RhCMV/SIV Vaccine-Induced Replication Arrest Efficacy
OVERALL - PROJECT SUMMARY Almost 2 decades ago our research group began development of vaccine vectors based on the persistent β- herpesvirus Cytomegalovirus (CMV) because of the...
B and T Cell Biology of Protection from and Eradication of SIV/SHIV Infection
ABSTRACT The Emory Consortium for Innovative HIV/AIDS Vaccine and Cure Research in Nonhuman Primates aims to define the mechanisms of the B and T Cell Biology of Protection from...
National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Core Project
Project Summary This project, developed in response to RFA-AG-21-008, describes core plans for data collection and dissemination of the sixth wave (Wave VI) of the National Longi...
REVERSE-Long COVID: A Multicenter Randomized, Placebo-Controlled Clinical Trial of Immunomodulation (with Baricitinib) for Long COVID Related ADRD
PROJECT SUMMARY/ABSTRACT Cognitive impairment, including Alzheimer’s Disease and Related Dementias (ADRD), and cardiopulmonary dysfunction following COVID-19, are components of t...
BRAIN CONNECTS: Center for a pipeline of high throughput integrated volumetric electron microscopy for whole mouse brain connectomics
Project Summary: Center for whole mouse brain connectomics using high-throughput integrated volumetric electron microscopy (HIVE) Two fundamental components of the structural b...
Enterprise for Research and Advocacy to Stop and Eradicate HIV (ERASE-HIV)
Abstract The presence of a reservoir of cells harbouring integrated, replication-competent virus that persists under long- term, fully suppressive antiretroviral therapy (ART) an...
Institute for Integration of Medicine & Science: A Partnership to Improve Health
Project Summary-Abstract South-Central Texas is home to San Antonio and Austin, both among the nation’s fastest growing cities. San Antonio, the gateway to South Texas, is the 7t...
Experimental and Computational Analysis of the Human Epidemiology and Response to SARS-CoV-2 (HEROS) Cohort
PROJECT SUMMARY Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the general population. AD is associated with defective skin barrier function, microb...
The Environmental Factors in FEtal to Childhood Trajectories Cohort
PROJECT SUMMARY / ABSTRACT The Environmental influences on Child Health Outcomes (ECHO) Pediatric Cohorts program launched in 2016, bringing together more than 30 extant cohorts...
The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve Health
ABTRACT The Ohio State University (OSU) Center for Clinical and Translational Science (CCTS) was formed in 2007, with the vision to advance today’s discoveries to improve health...
Delaney AIDS Research Enterprise to Cure HIV
PROJECT SUMMARY/ABSTRACT The goals of the DARE Collaboratory are to develop a viable combination regimen that reduces the rebound- competent HIV/SIV reservoir during antiretroviral...
Preclinical Development of Novel Dual OXR/KOR Antagonists for Treatment of Substance Use Disorder
ABSTRACT (Project Summary) Substance use disorder (SUD) characterized by the repeated use of an addictive substance leading to loss of intake control represents a serious public he...
Institute for Integration of Medicine & Science: A Partnership to Improve Health
Project Summary-Abstract South-Central Texas is home to San Antonio and Austin, both among the nation’s fastest growing cities. San Antonio, the gateway to South Texas, is the 7t...
Defining Mechanisms of Pain Relief Associated with Dorsal Root Ganglion and Spinal Cord Stimulation
Chronic pain is a debilitating condition for which there is a pressing need for safe, effective treatments as is highlighted by the ongoing opioid crisis. One potential solution t...
REACH: Research Enterprise to Advance a Cure for HIV
PROJECT SUMMARY/ABSTRACT Despite the success of standard antiretroviral therapy (ART), the need for an HIV cure remains compelling, both to improve the lives of PWH and to bring...
A regulome and transcriptome atlas of fetal and adult human neurogenesis
PROJECT SUMMARY Dynamic changes in the spatiotemporal patterning of transcription factor binding on cis-regulatory DNA elements drives the developmental transition of cell lineages...
National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Core Project
Project Summary This project, developed in response to RFA-AG-21-008, describes core plans for data collection and dissemination of the sixth wave (Wave VI) of the National Longi...
The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve Health
ABTRACT The Ohio State University (OSU) Center for Clinical and Translational Science (CCTS) was formed in 2007, with the vision to advance today’s discoveries to improve health...
ACTIVE MIND: An adaptive clinical trial of cognitive training to improve function and delay dementia
PROJECT SUMMARY Dementia such as Alzheimer's disease (ADRD) is the most expensive medical condition20 in the US and affects more than 5 million Americans21. Analyses from the ACT...
REACH: Research Enterprise to Advance a Cure for HIV
PROJECT SUMMARY/ABSTRACT Despite the success of standard antiretroviral therapy (ART), the need for an HIV cure remains compelling, both to improve the lives of PWH and to bring...