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99,167 grants found
Showing 2,761 – 2,780 of 99,167 grants
Administrative Core
Enteric Cooperative Centers on Human Immunology (Enteric CCHI) University of Maryland, Baltimore Enteric CCHI Administrative Core ABSTRACT The Administrative Core for the Enteric C...
Clinical Core
Project Summary The specific objective of the Clinical Core is to provide human specimens for the studies outlined in Research Projects (RP) 1-3. These human specimens will supplem...
Systems Biology and Biostatistics Core
CORE 2 SUMMARY The overall goal of the Systems Biology and Biostatistics Core is to provide service to advance the knowledge of systemic and gut human immunity in children and adul...
Imaging Mass Cytometry Core
PROJECT SUMMARY - Core 3: Imaging Mass Cytometry Core The overall goal of the proposed CCHI U19 grant is to determine the mechanisms of mucosal immune responses to human-restricted...
Mechanisms of Induction and Maintenance of Systemic and Gut Mucosal T Cell Immunity to Salmonella and Shigella Following Infection and Vaccination in Children and Adults
RP1 PROJECT SUMMARY/ABSTRACT Enteric diseases caused by Salmonella (typhoidal and non-typhoidal -NTS-) and Shigella (multiple serotypes) remain a major health problem worldwide esp...
Immune Mechanisms Regulating the Development of Systemic and Mucosal Antigen-specific B Cells After Vaccination and Challenge in Humans
CCHI Research Project 2 – Abstract Shigellosis and salmonellosis continue to be serious public health problems affecting primarily young children in developing countries; however,...
Role of Epigenetics and their Pharmacological Modulators in Innate Intestinal Immunity and Adjuvanticity in Humans
PROJECT SUMMARY/ABSTRACT The intestinal immune system has evolved to tolerate most antigens while mounting an effective immune response to combat infections by pathogens. Epigeneti...
Center for the Study of Complex Malaria in India
OVERALL SUMMARYIndia, the world's largest democracy and soon-to-be most populous country, has shown a sustained decline in malaria cases over the past decade. However, malaria...
Administrative Core
ADMINISTRATIVE CORE SUMMARY The Administrative Core of the Center for the Study of Complex Malaria in India (CSCMi) provides capacity for day-to-day administrative, accounting, and...
Data Management Core
CSCMI DATA MANAGEMENT CORE SUMMARY The Data Management and Biostatistics Core (“Data Core”) provides data management, statistical, and bioinformatics support for the Center for the...
PROJECT 1: Identifying Reservoirs of Plasmodium Infections in Odisha, India
PROJECT 1 SUMMARYMaintenance of Plasmodium cases in Odisha, India, continues despite active efforts by the state malaria control program targeting high endemicity foci with mass sc...
Project2: Developing New Diagnostic Tools for the Detection of Plasmodium Infection Across the Spectrum of Disease Severity
PROJECT 2 SUMMARY Novel and more granular methods of diagnosis of Plasmodium infection are urgently needed in India, where several important barriers to elimination have recently c...
Targeting hepatitis B virus cccDNA during HBV/HIV co-infection
Project summary Coinfection with HBV and HIV-1 is common, and HIV coinfection can exacerbate progression of viral hepatitis and accelerate liver disease progression. In fact, endst...
Systems Genetics of Tuberculosis
Systems Genetics of Tuberculosis. Overall Program Abstract: Mycobacterium tuberculosis (Mtb) infection outcomes are highly variable. Most individuals contain the infection and rema...
Core C Admin Core
CORE C: ADMINISTRATIVE (Core Leader: Chris Sasse9) Abstract: The success of the Systems Genetics of Tuberculosis (SGTB) Program requires a robust scientific and programmatic infras...
Core A Mouse Genetics and Genomics Core
Core A: Mouse Genetics and Genomics (Core Leader: Ferris) Abstract Mouse models of human diseases, such as Mycobacterium tuberculosis (Mtb), have proven invaluable for understandin...
Core B Computational Modeling and Analysis
ABSTRACT: CORE B -- COMPUTATIONAL MODELING & ANALYSIS (Core Leader: Lauffenburger) A key premise underlying the motivation for this program is that there exist multiple molecul...
Project 1 Immunometabolic Determinants of Susceptibility
Project 1: Immunometabolic determinants of host susceptibility (Project Leader: Sassetti). ABSTRACT: Mycobacterium tuberculosis (Mtb) infection in different individuals, or even in...
Project 2 Bacterial determinants of host adaptation and evolutionary success
Project 2: Bacterial genetic determinants of susceptibility (Project Leader: Sarah Fortune) Abstract: Mycobacterium tuberculosis (Mtb) is an incredibly successful human pathogen, e...
Neuropathogenesis of Rift Valley fever virus
Neuropathogenesis of Rift Valley fever virus Rift Valley Fever virus (RVFV) infection causes a spectrum of disease including self-limiting febrile illness, hepatitis, and late onse...