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99,167 grants found
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Exploiting glycan holes and sequence diversity of naturally occurring HIV envelope towards the design of vaccine immunogen panels for induction of neutralization breadth
PROJECT SUMMARY/ABSTRACT Vaccine-mediated protection against viral pathogens frequently depends on neutralizing antibodies. However, the HIV-1 envelope (Env) glycoprotein gp120 is...
Mechanisms of mitochondrial dynamics, quality control and mtDNA-mediated inflammation in alcohol-associated liver disease
Project Summary/Abstract Despite recent progress on understanding the mechanisms of alcohol-associated liver disease (ALD), no successful treatment for ALD is available. Alcohol me...
Identification of Early HFpEF after Preeclampsia by Exercise Stress Testing
ABSTRACT Pregnancy is a unique, early moment of cardiovascular stress in young women that may “unmask” cardiovascular disease (CVD) propensity. Preeclampsia (PreE)—characterized by...
The Re-Engineered Discharge for Diabetes Care Transitions (REDDCAT2): Screening and Addressing SDOH Needs at Hospital Discharge
REDDCAT2 Project Abstract Summary Over 36 million Americans are diagnosed with type 2 diabetes mellitus (T2DM), accounting for more than 7.8 million hospital admissions and $327 bi...
A Service User Informed Study of Certified Community Behavioral Health Center (CCBHC) Implementation and Impact in New York State
This is a service-user informed mixed-methods study of the implementation and impacts of the Certified Community Behavioral Health Clinic (CCBHC) program in New York State. CCBHCs...
Efficacy of a Smartphone-based Just-in-Time Adaptive Intervention to ReduceDrinking among Adults Experiencing Homelessness
PROJECT SUMMARY/ABSTRACT Approximately 1 out of every 3 adults experiencing homelessness has a current alcohol use disorder (AUD). Alcohol use plays a central role in increased mor...
Evaluating Telehealth Delivery of Brief Alcohol Screening and Intervention for College Students
Project Summary/Abstract The proposed research study will test the efficacy of a telehealth version of the Brief Alcohol Screening and Intervention for College Students (BASICS), w...
BDNF in the ventral hippocampus and the acute and chronic actions of alcohol
MODIFIED SPECIFIC AIMSAlcohol has been consumed by humans for more than 4000-years. Luckily, approximately 85%-90% of individuals who consume alcohol socially never develop alcohol...
Novel mechanisms of HIV-associated pulmonary vascular disease
PROJECT SUMMARY Thanks to the advent of combination antiretroviral therapy (cART), life expectancy has dramatically increased in people with HIV (PWH) and the spectrum of diseases...
Rifapentine in High Doses in Pregnancy with TB (Radiant-Moms) study
SUMMARY The risk of tuberculosis (TB) is twice as high during and immediately after pregnancy than any other time in a person’s life, and pregnant people with TB who are co-infecte...
Targeting the HIV-1 reservoir at cART initiation with CD4-mimetic interventions
Summary Combination antiretroviral therapy (cART) fails to eliminate HIV-1 persisting in reservoirs or prevent long-term complications in people living with HIV (PLWH); therapy int...
Continuing to Support and Enhance an Integrated Food Safety System Through Implementation of Program Standards, Data Sharing, Collaboration, and State Training and Equipment Grants.
AFDO 2024 Alliance to Support the Activities of the Integrated Food Safety System (IFSS), including the Grade A Milk Safety and National Shellfish Sanitation Programs Application:...
Optimization of novel inhibitors of human cytomegalovirus
Summary: Human cytomegalovirus (CMV) is a β-herpes virus with high seroprevalence rates of 60-90% within the population that can spread through bodily fluids, organ transplants, an...
A Tunable Nanophage Platform for Vaccine Development
PROJECT SUMMARY Newly emerging and long-standing infectious challenges, including arboviruses, Ebola virus and pandemic coronaviruses (CoVs), among others, pose serious public heal...
Continued Clinical Development of a Novel Pleural and Tracheal Sealant
PROJECT ABSTRACT A range of lung diseases and critical illnesses, including complications of mechanical ventilation, as well as trauma can result in air leak from the lung (pneumot...
Role of Beta Spectrin and Smad in Alcohol-Induced Liver and GI Cell Proliferation
PROJECT SUMMARY Alcohol-related liver disease (ALD) and nonalcoholic steatohepatitis (NASH) are two reasons Americans mostly require a liver transplant. Furthermore, aldehyde dehyd...
Mycobacterium avium complex pulmonary infection: immunologic and transcriptomic signatures of disease and treatment response
PROJECT SUMMARY/ABSTRACT We seek to define immunologic and transcriptomic signatures of Mycobacterium avium complex (MAC) pulmonary disease and microbiologic treatment response. No...
DNA transduction in intestinal microbiomes and the spread of pathogenicity traits
Project Summary Horizontal gene transfer (HGT) is a driver of rapid evolution and adaptation in microbial communities. HGT spreads genes among and between bacterial species and is...
Deconstructing antiseizure mechanisms of anterior thalamic nucleus electrical stimulation
PROJECT SUMMARY/ABSTRACT Epilepsy is one of the most prevalent neurological disorders. Patients with epilepsy experience abnormal brain activity causing seizures or periods of unus...
Mechanisms of Mucosal and Systemic Immunity to Vaccination and Infection with Enteric Pathogens in Children and Adults
Overall - Abstract Enteric bacterial infections are a significant global health concern, particularly in developing nations, where they disproportionately affect children. These di...