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99,167 grants found
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Reaching New Heights: Strengthening Health Professions Research at a Majority Hispanic-Serving Institution
Project Summary Although health professions (allied health, nursing, social work, clinical psychology) represent more than 80% of the healthcare workforce, rigorous research within...
The Future of Rural Health: Accelerating Biomedical Excellence at TTUHSC
Abstract: This NIH STRONG-RLI proposal submitted in response to PAR-23-144 is entitled The Future of Rural Health: Accelerating Biomedical Excellence at Texas Tech University Healt...
CYP1B1+PRRX1+NR4A2+ hepatic stellate cells in alcohol-associated hepatitis
SUMMARY Hepatic stellate cells participate in liver wound healing but also in progression of liver fibrosis and promotion of liver cancer. Heterogeneous subsets of activated HSC (a...
Adolescents' Social Media Use and Internalizing Symptoms: Mechanisms of Risk and Resilience
Project Summary/Abstract Rates of internalizing symptoms (depression, anxiety) among youth have increased significantly over the past decade. During this same time period, the use...
Optimizing Smart Digital Therapeutic Message Components for Engagement and Clinical Outcomes for Alcohol Use Disorder
Project Summary Clinician-delivered relapse prevention interventions for alcohol use disorder (AUD) are effective when delivered but the vast majority of adults with an active AUD...
Elucidating Roles of Distinct Spinal Cord Cell types in Mediating Interstitial Cystitis (IC)/Bladder Pain Syndrome (BPS)
Abstract Interstitial cystitis/bladder pain syndromes (IC/BPS) are a debilitating painful condition with unknown etiology. The cells and the circuits in the spinal cord that proces...
Closing the Adolescent and Young Adult Clinical Trial Enrollment Gap with an AYA (Alert, Young Adult Navigation and Alliance) Clinical Tool
Project Summary More than 80,000 adolescents and young adults (AYAs, ages 15- 39-years) are diagnosed annually with cancer in the United States, but relatively few enroll on cancer...
Antimicrobial Blue Light Emitting Envelope for the Control of Cardiac Implantable Electronic Device Infections
PROJECT SUMMARY/ABSTRACT Infections related to cardiac implantable electronic devices (CIEDs) are associated with significant morbidity and mortality. The capability of bacteria to...
Essential functions of the mitochondrion in malaria parasites
PROJECT SUMMARY Malaria is a devastating disease that impacts millions of people on an annual basis. While several species of Plasmodium parasites cause malaria in humans, P. falci...
The Roles of Parental Mental Health and Help-Seeking: Utilizing a Family Systems Approach to Upstream Suicide Prevention for Sexual Minority Youth
Project Summary Before leaving high school, approximately 1 in 4 sexual minority adolescents will attempt to end their own life; a rate that is nearly four times higher than their...
Platinum Based Countermeasures and Combinations with Protective Agents
ABSTRACT This project's primary endpoint focus will be efficiently rescuing toxic cyanide exposure using three distinct animal models. None of the current countermeasure optio...
Ultra-high precision image-guided incisionless transcranial ultrasound surgery
PROJECT SUMMARY Each year, nearly 2 million Americans receive a cancer diagnosis, with surgical removal being the primary treatment approach for solid tumors. Nowhere are the chall...
Unraveling the Mechanisms of Alcohol-Induced Blood-Brain Barrier Disruption: A Focus on Lysophosphatidic Acid Signaling and Endothelial Cells.
Alcohol consumption is a major risk factor for cerebrovascular complications and neuroinflammation, yet the underlying mechanism of alcohol-induced cerebrovascular damage remains u...
Time sensitive research on barriers to pregnancy care
Recent and seismic policy shifts in the Midwest of the United States have abruptly restricted access to abortion and other pregnancy-related care for millions of people. Following...
Pre-Analytic Factors affecting Molecular tests for Congenital Syphilis
PROJECT SUMMARY Syphilis, caused by Treponema pallidum spp pallidum (T. pallidum), cases are rising at an alarming rate with devastating consequences for pregnant individuals and n...
Video Disease Activity Index: A novel video measure to monitor rheumatoid arthritis in telehealth
Title Video Disease Activity Index: a video measure to monitor rheumatoid arthritis in telemedicine Project Summary/Abstract Rheumatoid arthritis (RA) is a degenerative autoimmune...
A novel model of severe inflammatory arthritis induced by pulmonary silica exposure
Occupational silica exposure is linked with systemic autoimmune diseases including rheumatoid arthritis (RA) systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and anti-...
Delivery of apoptotic neutrophils to improve angiogenesis during wound healing
PROJECT SUMMARY/ABSTRACT Every year, millions of patients suffer from impaired wound healing due to injuries, surgeries, and diseases, creating a significant public health and econ...
Molecular and cellular mechanisms of visceral pain and cross-organ sensitization
PROJECT SUMMARY/ABSTRACT Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic disorder characterized clinically by recurring episodes of pelvic pain and increased urin...
Neural Circuit Effects of Chronic Alcohol
Project Summary Chronic alcohol use has long-lasting detrimental effects on human cognition and behavior that result from changes in brain function. Here we examine changes in cort...