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99,167 grants found
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Data-Management-Core
PROJECT SUMMARY- CORE B The Data Management and Sharing (DMS Core) will be integral to the Bunyavirus and Picornavirus Pandemic Pathogen Preparedness (BP4) Center. The DMS Core wil...
Structural Biology Core
PROJECT SUMMARY - CORE C Bunyaviruses and Picornaviruses are RNA viruses that cause outbreaks of human disease. Given their diversity and mechanisms of transmission, they represent...
Vaccines and Therapeutics Technology Core
PROJECT SUMMARY - CORE D The Vaccine and Therapeutics Technologies (VTT) Core will focus on developing a rapid pipeline for next- generation vaccine and therapeutic antibody candid...
Virologic and Immunologic Sample Acquisition Core
PROJECT SUMMARY – CORE E Virologic and Immunologic Sample Acquisition Core (VISAC) Preparedness for the next pandemic relies upon improved understanding of both emerging viruses an...
Design and testing picornavirus vaccine candidates
PROJECT SUMMARY – RP1 Design and testing of picornavirus vaccine candidates The need for effective vaccines against enteroviruses and rhinoviruses cannot be overstated. Given the e...
Protective human antibodies for picornaviruses
PROJECT SUMMARY - RP2 Picornaviruses are an ever-present threat to human health, causing myriad diseases ranging from mild (common colds, hand, foot, and mouth disease) to more sev...
Nucleic acid vaccines targeting hantaviruses
PROJECT SUMMARY – RP3 RNA vaccines are one of the most promising vaccine platforms available to rapidly deploy in response to emerging viral infections with pandemic potential. How...
Human monoclonal antibodies for hantaviruses
PROJECT SUMMARY – RP4 The hantaviruses represent collections of diverse virus species, and these groups of viruses are ideal for prototype pathogen immunity approaches. The goal of...
Vaccines and antibodies for arenaviruses
PROJECT SUMMARY - RP5 Arenaviruses, a family of viruses with pandemic potential, can cause hemorrhagic fever, meningitis, and other clinical syndromes. These viruses include highly...
Understanding Mechanisms of Antibiotic Inhibition of Ribosomal Subunit Joining
Project Summary / Abstract Antimicrobial resistance is rapidly on the rise due to the excessive use and over-prescription of antibiotics in agriculture and medicine. Consequently,...
Applied Implementation Research for Clean Cooking in Cambodia (AIR-C3): equity, exposure, costs, and benefits of induction stove interventions
The goal of this study—Applied Implementation Research for Clean Cooking in Cambodia (AIR-C3)—is to design and demonstrate the effectiveness of a scalable strategy for achieving eq...
Nanohybrid Composites Minimize Antibiotic Resistant Infections
PROJECT SUMMARY/ABSTRACT: Open fractures are frequently (more than 150,000 cases in the U.S. every year) seen and have high (~10%) infection rates. Open fracture-associated infecti...
Genetic screens in zebrafish to identify gene-ethanol interactions
Project Summary/Abstract Ethanol is the most common teratogen and the leading cause of mental retardation. Fetal alcohol exposure can cause numerous birth defects, most commonly ef...
Cell-penetrating botulinum proteases as topical therapeutics
ABSTRACT The importance of communications between nerve cells and immune cells in skin has been increasingly recognized, as are the contributions of sensory neurons and the neurope...
Adipocytes and inflammation in the cutaneous leishmaniasis outcome
Summary Leishmania braziliensis infection may cause a high spectrum of clinical manifestation, including the more prevalent form, cutaneous leishmaniasis (CL). Inflammatory respons...
Novel Lassa fever live-attenuated vaccine platform with safety features ensuring unbreachable attenuation
Project Summary/Abstract The mammarenavirus Lassa (LASV) is endemic to West Africa where it infects several hundred thousand individuals yearly resulting in a high number of Lassa...
Translational Control of Host Environmental Stress Responses in Candida albicans
PROJECT SUMMARY/ABSTRACT Candida albicans is a major human fungal pathogen responsible for a wide variety of systemic and mucosal infections. Immunocompromised individuals, includi...
Motor Outcomes to Validate Evaluations in Pediatric FSHD (MOVE Peds)
The primary goal of this proposal is to hasten therapeutic development by validating outcomes and refining clinical trial strategies for pediatric-onset FSHD. Cross sectional studi...
Mechanisms and means to improve HIV bnAb activity in vivo
ABSTRACT A number of anti-HIV-1 broadly neutralizing antibodies (bNAbs) targeting highly conserved and vulnerable epitope regions of the envelope glycoprotein (Env) are being inves...
Emotional Granularity and Interoceptive Accuracy: Affective Skills Linking Dimensions of Childhood Adversity with Adolescent Stress Vulnerability
PROJECT SUMMARY Childhood adversity is common and increases risk for multiple forms of psychopathology emerging in adolescence. Heightened sensitivity to stress is one pathway thro...