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99,167 grants found
Showing 2,681 – 2,700 of 99,167 grants
Early onset colorectal cancer: from symptoms to treatment in a large, safety-net cohort
PROJECT SUMMARY (ABSTRACT) Early-onset colorectal cancer (EOCRC; CRC diagnosed at < 50-years of age) is a known and worsening public health problem, with alarming increases in i...
Peptides for the treatment of pulmonary fibrosis
ABSTRACT Fibroproliferative illnesses leading to organ fibrosis and failure are responsible for approximately 45% of deaths in developed countries. Whether idiopathic, triggered by...
Engineering simian-compatible HIV-1
PROJECT SUMMARY/ABSTRACT Construction of infectious and pathogenic HIV-1, or HSIV -- an essentially HIV-1 backbone having minimal SIV gene fragments -- for the simian model will br...
Glycosaminoglycan Targeting Treatment for Prostatic Hyperplasia and Fibrosis
Benign prostatic hyperplasia (BPH) is an age-related progressive pathologic condition in aging men. More than 50% of patients with BPH have lower urinary tract symptoms (LUTS), a c...
Role of putative cytotoxins in Chlamydia infection
ABSTRACT Chlamydia species are important pathogens that represent a paradigm for understanding successful obligate intracellular parasitism. C. trachomatis is a prevalent human pat...
MicroRNA Control of Dilated Cardiomyopathy
Summary of Parent R01 (HL130840): Dilated cardiomyopathy (DCM)-associated heart failure is a leading cause of mortality worldwide. About a third of DCM is due to gene variants in a...
Novel Hepatitis B Vaccine and Immunotherapy
Project Summary Hepatitis B virus (HBV) infects over 250 million people worldwide and is a leading cause of liver cirrhosis and cancer in many countries. The unique life cycle of H...
Project 3 Determinants of Vaccine Efficacy
Project 3: Determinants of Vaccine Efficacy (Project Leader: Behar) Abstract The bacterium Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB), which is a leading cause of gl...
The UCI Vaccines for Pandemic Preparedness Center (VPPC)
Project Summary/Abstract – Overall: The UCI Vaccines for Pandemic Preparedness Center (VPPC) The Mission: "To contribute to human health and well-being by developing agile, sa...
Administrative Core
Project Summary/Abstract – Administrative Core We are proposing the creation of the UC Irvine Vaccines for Pandemic Preparedness Center (VPPC), a consortium that will conduct basic...
Data Management Core
Project Summary/Abstract – Data Management Core A well-functioning Data Management Core (DMC) is essential to the success of the UCI Vaccines for Pandemic Preparedness Center (VPPC...
Regulatory Science Core
Project Summary/Abstract - Regulatory Science Core Establishing early a regulatory-enabling research framework is essential for the successful translation of promising target biome...
Translational Immunology Core
Project Summary/Abstract – Translational Immunology Core There are several virus families with serious pandemic potential but for which we currently have no effective vaccines. Dev...
Antibody, Epitope and Machine Learning Core
Project Summary/Abstract - Antibody, Epitope, and Machine Learning Core The overall goal of the Center is to develop vaccine candidates against prototype viruses in the bunyavirus,...
Project 1: Adjuvanted Protein Vaccines for Pandemic Preparedness
Project Summary/Abstract - Project 1: Adjuvanted Protein Vaccines for Pandemic Preparedness In preparation for possible future pandemics, our goals for Project 1 are to characteriz...
Project 2: mRNA vaccine development against Bunyaviruses, Paramyxoviruses and Picornaviruses
Project Summary/Abstract – Project 2: mRNA Vaccine Development against Bunyaviruses, Paramyxoviruses and Picornaviruses As the emergence of new pathogenic outbreaks in the future i...
Project 3: Peribunyaviridae Pathogenesis and Vaccine Testing
Project Summary/Abstract – Project 3: Peribunyaviridae Pathogenesis and Vaccine Testing The orthobunyaviruses (OBVs) of Peribunyviridae cause disease in humans manifesting with fev...
Project 5: Multi-scale development and evaluation of broadly-effective vaccines against picornaviruses with pandemic potential
Project Summary/Abstract – Project 5: Multi-scale development and evaluation of broadly-effective vaccines against picornaviruses with pandemic potential Picornaviruses are the mos...
Bunyavirus and Picornavirus Pandemic Pathogen Preparedness (BP4) Center
Project Summary Pathogenic picornaviruses and bunyaviruses have an enormous impact on public health worldwide, and our understanding of mechanistic correlates of immunity for membe...
Admin-Core
PROJECT SUMMARY - CORE A The central offices and administrative staff of the Vanderbilt Vaccine Center (VVC) will house the BP4 Administrative Core, which will play a critical role...