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Genetics of Osteoarthritis Susceptibility, Heterogeneity and Progression
The societal and patient-centered impacts of osteoarthritis (OA) are profound – total costs for OA treatment in the US exceed $486 billion annually. OA management is limited to sym...
Determining the Genetic Basis of Hidradenitis Suppurativa
PROJECT SUMMARY/ABSTRACT Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that has a devastating effect on quality of life. HS affects up to 1.2% of people and...
Visualization of extracellular morphogens to understand self-organized patterning
Project Summary During embryonic development, extracellular proteins, known as morphogens, play a key role in conveying positional information and establishing cell fates. While th...
Implementing an Evidence-Based Trauma Treatment with Community-led PrEP Navigation for Transgender and Gender Diverse Individuals Affected by Violence and HIV.
PROJECT ABSTRACT HIV prevalence is high among transgender and gender-diverse/expansive (TGD) individuals in the Ending the HIV Epidemic (EHE) priority jurisdiction of Los Angeles C...
Defective HIV proviruses and Persistent Innate Immune Activation
Abstract/Summary CD4+ T cells and macrophages are infected by HIV and this infection correlates to more proinflammatory activities that drive HIV comorbidities and end organ diseas...
Binge Eating as a Mechanism Underlying the Food Insecurity-Obesity Paradox in Adolescents
PROJECT SUMMARY/ABSTRACT Food insecurity is paradoxically associated with elevated risk of adolescent obesity in the United States. The mechanisms underlying this excess risk are n...
The Impact of Leukocyte-derived Cytokines on Ovulation in Humans
PROJECT SUMMARY/ABSTRACT Mid-cycle gonadotropin-induced ovulation, a pivotal event in female reproductive physiology, shares many features with an acute inflammatory response, nota...
A type I hybrid effectiveness-implementation study of a parent-centered tool to promote shared decision-making in hypospadias care
SUMMARY/ABSTRACT Hypospadias, a urethral opening on the underside of the penis, is one of the most common birth defects in boys (1 in 250 newborns). Left untreated, hypospadias may...
Protein interactions that control calcium oxalate stone formation
Kidney stones remain an enigmatic disease despite decades of work by many investigators with no real advancement in calcium oxalate (CaOx) stone treatment for more than 20-years, b...
FHOD3 Regulation of Autophagy Pathway in Cardiomyopathy
Project Summary Cytoskeletal remodeling and turnover are central contributors to left ventricular (LV) remodeling that underlies cardiomyopathy and heart failure. Formin homology 2...
Localization of Antibody Drugs to Arthritic Joints via Collagen Hybridization
PROJECT SUMMARY (PI: YU) Since bones and cartilage (B&C) are common sites of serious degenerative diseases (e.g. cancer, arthritis, osteoporosis), a strategy to localize therap...
Identifying Targets for Preventing Neurocognitive Complications in Youth with T1D
PROJECT SUMMARY/ABSTRACT Early childhood is a critical time in brain development for later health and maturation. During this period of rapid brain development, the brain may be es...
Discovery of human metapneumovirus epitopes
Discovery of Human HLA T Cell Epitopes in Human Metapneumovirus HMPV is a leading cause of lower respiratory infection in children and adults worldwide. Although nearly all people...
MEPCS (Multi-epitope protease cleavage sites) vaccine for protecting against SIV rectal transmission
Summary Novel vaccine strategies is needed to develop a safe, effective, and broadly accessible HIV vaccine to end the HIV pandemic. This proposal is built upon several innovative...
Molecular Determinants and Behavioral Fingerprints of Schistosome Miracidia Host-Seeking
Schistosomiasis is a disease caused by chronic infections of human schistosomes, parasitic flatworms that are transmitted by aquatic snails. Schistosomes cause disease in over 250 m...
Real-time Monitoring and Correction of Clinical Decision Support Systems to Reduce Health Disparities
Project Summary/Abstract This project develops artificial intelligence (AI)/machine learning (ML) methods that provide real-time monitoring and updating of clinical decision suppor...
Allogeneic virus-specific T-cell therapy after hematopoietic stem cell transplant: determinants of treatment success and failure
ABSTRACT: Infections caused by double stranded DNA viruses are a common complication after allogeneic hematopoietic stem cell transplantation (HSCT), occurring in 82% of patients u...
Artificial Intelligence-Based Methods to Characterize Kidney Macrostructure from Pre- and Post-Nephrectomy Computed Tomography Images
PROJECT SUMMARY/ABSTRACT The prevalence and burden of chronic kidney disease (CKD) is increasing worldwide. Patients who undergo radical or partial nephrectomy for kidney cancer re...
Development of a novel syphilis molecular diagnostic assay for a point-of-care multiplexed genital ulcer panel test on giant magnetoresistive biosensors
PROJECT SUMMARY There is a large unmet need for fast and effective point-of-care (POC) molecular diagnostic (MDx) testing for congenital and adult acquired syphilis. Current syphil...
Machine learning in publicly available geotagged data to allow monitoring of maternal and child health
Over 95 percent of maternal and child deaths globally occur in low- and middle-income countries (LMICs) where reliable death registries are mostly unavailable and other dependable...