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Motivate, Vaccinate, Activate’: An effectiveness-implementation trial to assess the impact of a multi-component community-based intervention to increase RSV vaccine uptake among Latino older adults
PROJECT SUMMARY/ABSTRACT Respiratory Syncytial Virus (RSV) causes a substantial burden of hospitalizations and deaths among older adults, comparable to that of influenza. The new a...
Examining the determinants and consequences of supportive care medication use disparities in patients with pancreatic cancer: A sequential mixed-methods approach
PROJECT SUMMARY Pancreatic cancer (PC) is a significant public health issue and is the third leading cause of cancer deaths in the U.S. PC is associated with significant neurologic...
Novel coenzyme Q6 variant reveals non-immune determinants of survival during pneumococcal sepsis
1 PROJECT SUMMARY 2 Sepsis caused by Streptococcus pneumoniae (Sp; the pneumococcus) causes significant morbidity and 3 mortality, despite vaccines, antimicrobials, and supportive...
Breast Cancer Diagnostic Kit to Improve Early Diagnosis in Uganda
ABSTRACT: Breast cancer in Uganda presents a pressing public health challenge, characterized by late-stage diagnoses and high mortality rates, particularly among women residing in...
Mettl14 mediated mRNA methylation orchestrates postnatal cardiac development
The adult mammalian heart has limited capacity for regeneration following injury, but the neonatal mouse heart possesses remarkable regeneration capacity within 7 days after birth....
Targeted suppression of ALDH1A3 for endothelial beneficial management of restenosis after vascular surgery
Project Summary Angioplasty is commonly performed to press open occluded coronary and peripheral arteries. Unfortunately, this invasive procedure often induces smooth muscle cell d...
Uncovering and understanding the many functions of ICAM-1 in the lungs during homeostasis and innate immune responses
Abstract The gene Icam1 codes for intercellular adhesion molecule-1 (ICAM-1, CD54), a member of the Ig-like superfamily of adhesion proteins and a type 1 membrane-bound glycoprotei...
INTEGRATIVE GENOMICS OF CHILDHOOD INTERSTITIAL LUNG DISEASE
Children’s Interstitial and Diffuse Lung Diseases (chILD) are disorders of the lung tissue that present in infancy and early childhood. ChILD pose major burdens on thousands of chi...
Hormonal Drivers of Perimenopausal Inflammation and Mood Symptoms
Up to one third of women, up to a billion people, experience the emergence or worsening of depressive and anxiety (mood) symptoms as their hormonal milieu shifts into perimenopause...
Blood Gas Analysis Without the Laboratory
Project Summary/Abstract Blood gas analysis is a cornerstone of modern critical care medicine, providing essential insights into a patient's respiratory and metabolic status....
Supportive and restrictive factors and mental health in LGBT adolescent and young adult populations
PROJECT SUMMARY/ABSTRACT An unprecedented number of new policies across the US threaten the rights of lesbian, gay, bisexual, and transgender (LGBT) populations. In 2023, >500 d...
A translational human laboratory Pavlovian conditioning model of individual differences in risk for alcohol cue incentive salience sensitization and longitudinal assessment of problematic alcohol use
PROJECT SUMMARY/ABSTRACT This K99/R00 NIH Pathway to Independence Award will provide Dr. Cofresí, trained as a preclinical neuroscientist, with a two-year intensive, mentored train...
Regulation of alcohol-induced social disturbances by lateral habenula serotonin receptors
The COVID-19 pandemic has greatly exacerbated rising patterns of excessive alcohol consumption, particularly in women. Binge alcohol drinking is the most common pattern of excessiv...
COVID-19 Vaccine Coverage and General Vaccine Hesitancy in Rural Areas in the United States
PROJECT SUMMARY Two issues related to adolescent vaccination have recently come to the forefront of public health in the United States (US): coronavirus disease 2019 (COVID-19) vac...
A Rapid Phenotypic Drug Susceptibility Testing System for Tuberculosis
Abstract Tuberculosis (TB) is second only to COVID-19 as the most lethal cause of death from a single infectious agent. In 2020, an estimated 10 million people developed TB, nearly...
Optimal Window of Opportunity for Granulosa Cell Gene Therapy in Galactosemia
PROJECT SUMMARY / ABSTRACT Hereditary deficiency of galactose-1-phosphate uridylyltransferase (GALT, E.C. 2.7.7.12) activity in humans can lead to a potentially lethal disease call...
Child Abuse and Risk of Gynecologic Disease in a North American Cohort
ABSTRACT Uterine leiomyomata (UL), endometriosis, and polycystic ovarian syndrome (PCOS) are debilitating gynecologic conditions diagnosed in up to 30% of North American women. The...
LRRK2 and oxidative stress in Parkinson’s disease
Mutations in LRRK2 are the most common cause of autosomal dominant Parkinson's disease (PD) and it appears that all such pathogenic mutations are associated with aberrantly en...
EMERGE: Early Markers of Expressive and Receptive (language) Growth in Ethnically diverse autistic toddlers
PROJECT ABSTRACT The majority of 18-24-month-old autistic children have no words, demonstrating significant delays in their language development, a leading source of concern that o...
Massively Parallel Biochemical Annotation of Missense DNA Variants to Support Newborn Screening by Whole Genome Sequencing
Project Summary Newborn screening (NBS) provides early diagnosis of treatable disorders. Most NBS is based on measurement of biomarkers in dried blood spots (DBS). However, there a...