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99,167 grants found
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A CRISP(e)R approach to alleviating HIV-associated COPD
PROJECT SUMMARY People living with HIV demonstrate increased incidence of lung inflammation and HIV is an independent risk factor development of COPD. In the era of antiretroviral...
Multicenter, longitudinal study of acromioclavicular joint reconstruction techniques for restoring shoulder complex biomechanics and soft tissue health
PROJECT SUMMARY: Acromioclavicular joint (ACJ) injuries are one of the most prevalent shoulder injuries among young athletes participating in contact sports, which could have long-...
Targeting Glioblastoma Stem Cells
PROJECT SUMMARY/ABSTRACT Glioblastoma represents one of the most lethal types of cancers. Despite extensive molecular characterization, precision medicine efforts have largely fail...
Engineering a lab-on-a-particle platform to measure platelet function
PROJECT SUMMARY The purpose of the Bold New Bioengineering Research for Heart, Lung, Blood and Sleep Disorder and Diseases is to support early phases of groundbreaking bioengineeri...
iLookOut for Child Abuse: Micro-learning to improve knowledge retention
PROJECT SUMMARY/ABSTRACT The epidemic of child abuse in the U.S. (>675,000 confirmed annually) causes massive harm to children and the adults they become. Sequelae include physi...
Measuring and Mapping Trajectories of Risk and Resilience for Suicidal Thoughts and Behaviors in Sexual and Gender Minority Preteens
PROJECT SUMMARY/ABSTRACT Today's sexual and gender minority (SGM) youth are coming out at increasingly younger ages, with the average age of disclosure at 13-years old and 35%...
Macrophage LRRK2 activity regulates gut epithelial homeostasis
ABSTRACT Crohn’s disease (CD) pathogenesis includes gene-environment interactions. GWAS have identified >100 CD susceptibility genes. Among the CD susceptibility genes, LRRK2 is...
The Effectiveness of Cochlear Implants in Real-World Settings for Mild Cognitive Impairment and Dementia in Older Adults with Age-Related Hearing Loss
PROJECT SUMMARY ABSTRACT Age-related hearing loss (ARHL) results from the cumulative effects of aging on the auditory system. There is growing evidence linking ARHL with cognitive...
High-throughput functional analyses of the genetic drivers of Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD) is a debilitating condition characterized by chronic inflammation, leading to the erosion of essential intestinal functions. The risk of developing...
A Myocardial Approach to Identify the Cause of Cardiomyopathy
PROJECT SUMMARY/ABSTRACT Cardiomyopathy is classified into ischemic cardiomyopathy, caused by coronary artery disease, or non- ischemic cardiomyopathy, caused by other factors. The...
Peripubertal Social Motivation as a Novel Risk Factor Linking Childhood Threat Exposure and Suicidal Ideation and Behavior in Preteen Girls.
Project Abstract Suicide is the second leading cause of death for youth aged 10-12. Recent data from the CDC show that girls have greater rates of STBs than boys—1 in 3 adolescent...
Improving disease subtyping and physiological characterization of adult-onset diabetes in electronic health records
ABSTRACT Diabetes is broadly classified as type 1 diabetes (T1D), with primary defect in insulin production due to autoimmune destruction of beta cells, and type 2 diabetes (T2D),...
A mixed-methods, multi-informant study of childhood suicide ideation to improve risk assessment
Abstract Despite increases in suicides among children, we have no available developmentally and culturally informed measures of childhood suicide ideation (SI) to inform risk asses...
Resilience to Alzheimer's disease by targeting adult hippocampal neurogenesis
PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD), the most common form of age-related dementia, is characterized by cognitive impairment, neurodegeneration, β-amyloid (Aβ) deposit...
BRAIN CONNECTS: High-Throughput Single Cell Projection Mapping and Spine Quantification in the Primate Brain by Synaptic Barcoding
SUMMARY The primate brain contains trillions of highly specific synaptic connections that are the building blocks of neural computation. While tools available in rodents have begun...
Mechanistic Assessment of NMES to Rescue Localized Neuromuscular Disruption after ACL Injury
Project Summary Anterior Cruciate Ligament (ACL) injury and subsequent reconstruction result in disrupted neuromuscular pathways which have been linked to protracted quadriceps wea...
Addressing Factual Inaccuracy and Unfaithful Reasoning of Large Language Models in Biomedicine and Healthcare
PROJECT SUMMARY/ABSTRACT Large Language Models (LLMs) represent the latest advancement in Natural Language Processing (NLP) and Artificial Intelligence (AI), holding tremendous pot...
Protein arginine methyltransferase inhibitors in treatment of high-grade serous ovarian cancer and triple-negative breast cancer
PROJECT SUMMARY The expression levels of protein arginine methyltransferases (PRMTs) are significantly elevated in cancer cells and are associated with poor clinical outcomes. This...
Transforming motivational interviewing into a computable model for automated patient diabetic counseling.
Project Abstract The incidence of type 2 diabetes mellitus (T2DM) is staggeringly high in the United States, and it is expected to exponentially increase in the next few decades. R...
Liquid biopsy technology towards individualized immunosuppression therapy
PROJECT SUMMARY Transplantation of solid organs (liver, pancreas, spleen, adrenal glands, heart, lungs) can save the lives of many patients with irreversible organ disease or injur...