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99,167 grants found
Showing 241 – 260 of 99,167 grants
Diversity Supplement for Rohda Yase
PROJECT SUMMARY/ABSTRACT The objective of this Diversity Supplement is to support an 18-month postbaccalaureate research experience for Rohda Yase. Ms. Yase is a bachelor’s degree...
Close Relationships and Alcohol Use Disorder Risk
Project Summary/Abstract Models of alcohol use disorder (AUD) risk increasingly conceptualize relationship factors as being critical to theunderstanding of problem drinking. A subs...
The Mechanistic Impact of Paternal Electronic Nicotine Delivery Systems Exposure on Thrombogenesis
While the contribution of exposure of future fathers (paternal) to environmental factors, such as smoking, to the pathogenesis of several disease states has been documented, that o...
Assessing Tyrosine Kinase Inhibitors-induced Cardiotoxicity with an Organoid-AI System
PROJECT SUMMARY Tyrosine kinase inhibitors (TKIs) are specified small-molecule inhibitors of the activity of tyrosine kinases and have shown therapeutic impact on treating cancers....
PrEDICT ADRD: Predicting the Effects of Diagnosis in Individuals across Countries and Time in ADRD
PROJECT SUMMARY / ABSTRACT As the overall prevalence of mild cognitive impairment (MCI) and Alzheimer’s disease and related dementias (ADRD) grows, there is an urgent need to impro...
Overcoming tumor-intrinsic mechanisms of immune evasion to boost systemic response to radiotherapy
PROJECT SUMMARY/ABSTRACT Immune checkpoint blockade has revolutionized the therapeutic landscape of patients with metastatic cancer. However, despite remarkable outcomes in some pa...
Concentration and single virion analysis of the virome
ABSTRACT Clinical virology is predicated on the workflow of analyzing small sample volumes (to minimize patient discomfort, storage, and fit legacy infrastructure) for a single ana...
Perceived Norms About Alcohol Use and HIV/STI Prevention among Adolescents and Young Adults in Rural Uganda
PROJECT SUMMARY/ABSTRACT Adolescents & young adults (AYA) accounted for >400,000 new HIV infections in 2021 worldwide. Heavy alcohol use is a prevalent and strong modifiable...
Partnering with Antenatal Navigators to Transform Health in Pregnancy (PATH)
PROJECT SUMMARY In the US, pervasive and insidious disparities in maternal health are urgent public health concerns. Social determinants of health (SDoH), such as poverty, exposure...
Elucidating novel mechanisms in the pathogenesis of Alport syndrome
PROJECT ABSTRACT Alport syndrome is the second most common cause of hereditary chronic kidney disease and is caused by mutations in the type IV collagen genes encoding 3, 4 and ...
The Impact of Discrimination on Anthropometric Outcomes: An Analysis of the Adolescent Brain Cognitive Development (ABCD) Study
Project Summary Obesity disparities in children and adolescents have persisted for decades. The reasons for these disparities are not fully understood, despite research into factor...
Role of HIF-1 in intervertebral disc function
Our pioneering studies have shown that robust expression of HIF-1 allows NP cells to maintain their metabolism and bioenergetic needs in the hypoxic intervertebral disc. The applic...
Investigating single-T cell atopic gene networks in Asian and Hispanic genetic backgrounds
Investigating single-T cell atopic gene networks in Asian and Hispanic genetic backgrounds Project Summary/Narrative Immunomodulatory therapies now robustly improve atopic dermatit...
The role of the gut microbiota in alcohol seeking and decision-making
ABSTRACT The goal of this proposal is to investigate the role of the gut microbiota in alcohol seeking and reward-related decision-making. Alcohol is the leading risk factor for pr...
A user-customizable personalized normative feedback intervention for alcohol harm reduction in young adults: Feasibility, acceptability, and preliminary efficacy.
The proposed project entails (1) user-centered development of an innovative web-based intervention to reduce alcohol-related harm among young adults, and (2) pilot testing the inte...
Epigenetic aging as a driver of racial disparities in early onset prostate cancer
Prostate cancer (PrCa) shows significant racial disparities, especially impacting African American (AA) men, who have a 1.4 times higher risk of PrCa diagnosis, and a double risk o...
Adaptations and Impacts Understanding Teen Pregnancy Prevention Programs
Adaptations & IMpacts – Understanding Teen Pregnancy Prevention Programs (AIM-UP) Abstract: Adolescent pregnancies remain an area of marked health disparities, with significant...
Efficacy Testing of a Multi-Level Family Planning Intervention to Increase Contraceptive Use and Reduce Unintended Pregnancy in Low Resource Settings
Abstract In 2022, 29.7% of married women of reproductive age had an unmet need for family planning in Uganda, meaning they wanted to avoid pregnancy but were not using a modern con...
Cumulative Demographic and Health Effects of Climate Exposures
PROJECT SUMMARY This project will study how exposure to climatic variability (i.e., temperature and precipitation anomalies) during different phases of the life course, from early...
Norms re-education to promote engagement in parent-based interventions: A Type 1 implementation-effectiveness trial
Project Summary Underage drinking on college campuses remains a serious public health issue. Research suggests that Parent- Based Interventions (PBIs) that target parents of incomi...