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99,167 grants found
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Mesoscale correlative light-electron microscopy (CLEM) computational pathoconnectomes of degenerated retinas
Project Summary To this date, we are still uncovering the exact morphological and functional changes that retina cells undergo throughout retinal degenerative disease timecourse. F...
Modulating Blood-Brain Barrier Permeability by TRPV4 activation
Summary The long-term vision of this proposed research is to build the next generation of methods to put medicine into the brain and solve the most challenging and impactful neurol...
Dissecting the contributions of phase separation to yeast transcription .
Summary Transcription requires the coordinated recruitment of transcription factors, coactivators, and regulators to specific DNA elements with high spatial and temporal regulation....
GLIOMA INTERACTION WITH THE NEUROGENIC NICHE THROUGH EXTRACELLULAR VESICLES
PROJECT SUMMARY/ABSTRACT Glioblastoma (GBM) is the most common, aggressive and proliferative primary brain tumor in adults despite current therapeutic strategies that combine surge...
Late Neurological Sequelae after Cryptococcal Meningitis
Abstract Despite the success of Cryptococcal Antigen (CrAg) screening and the Test and Treat policy in reducing the prevalence of cryptococcal meningitis, it remains a leading caus...
Impact of Targeted Therapy on Cancer-Related Cognitive Impairment
PROJECT SUMMARY/ABSTRACT Cancer-related cognitive impairment (CRCI) is common and distressing among cancer survivors. An understudied area is the impact of targeted therapies, a ne...
Multimodal Assessment and Longitudinal Trajectory of Callous-Unemotional Behaviors in Young Children: The Role of Parental Emotion Socialization
PROJECT SUMMARY Conduct problem (CP) symptoms in early childhood, including aggression and defiance, are associated with adverse social, emotional, and behavioral outcomes extendin...
Toward understanding mechanisms of inadvertent lower extremity displacements from wheelchair footplates in Veterans with SCI/D: Multi-modal evaluation of leg movements during power wheelchair use.
Veterans with sensorimotor deficits due to spinal cord injuries and disorders (SCI/D) and other neurological disorders often use power wheelchairs (PWC) for independent mobility. W...
Domestication and characterization of TM7-the most elusive oral phylum
Abstract Saccharibacteria (also known as TM7) are ubiquitous members of the human oral microbiome whose relative abundance increases dramatically during mucosal inflammation (gingi...
Eicosanoids, Chronic Kidney Disease Progression, and Associated Cardiovascular Risk
PROJECT SUMMARY Over 800 million persons worldwide have chronic kidney disease (CKD) and experience a considerable two-to- three-fold excess risk for cardiovascular disease, starti...
Tau progression index (TPI): An individualized predictor of Alzheimer's Disease trajectory based on subject-specific connectomes
PROJECT SUMMARY Alzheimer’s disease (AD) is the leading cause of dementia, with the number of cases estimated to rise to 13 million by 2050 in the US alone . While amyloid-beta (Aβ...
A hybrid type III effectiveness-implementation, pragmatic intervention trial for cervical cancer screen and treat in Mozambique
PROJECT SUMMARY AND ABSTRACT Every year approximately 300,000 women die from cervical cancer, with over 90% of those deaths occurring in low-and middle-income countries (LMICs).1 T...
Kupewa: Optimizing strategies to implement provider recommendation of HPV vaccination for adolescent girls and young women with HIV in Malawi
Project Summary/Abstract Human papillomavirus (HPV) vaccination is a critical cancer control intervention, particularly in resource- constrained health systems with limited access...
The Impact of an Evidence-Based, Behavioral Cervical Cancer Screening Intervention among Women Living with HIV in Ghana (HOPE-inG): A Type 2 Hybrid Effectiveness Implementation Trial
ABSTRACT Over 69,000 women living with HIV, (WLWH) in Ghana have a six-fold increased risk of developing cervical cancer1 and require early and frequent cervical cancer screening (...
Implementation of Screen, Treat, and Triage for Women Living with HIV in La Romana (iSTAR)
PROJECT SUMMARY Cervical cancer is preventable, yet it remains one of the most common causes of cancer-related death in women in low- and middle-income countries (LMICs). Few disea...
ENHANcing CErvical cancer screening and treatment in women LIviNg with HIV in KenyA (ENHANCE LINKAge)
ABSTRACT In sub-Saharan Africa (SSA), human papillomavirus (HPV) and HIV create a dual burden of disease that causes significant morbidity and mortality in the form of cervical can...
We Are Together (WAT):Development and testing of an intervention to reduce HIV-related stigma among pregnant and postpartum women
Project Summary/Abstract Stigma is a significant barrier to HIV prevention and treatment . Stigma is associated with psychosocial challenges, including lack of social support and d...
PF614-MPAR: clinical development of opioid with oral overdose protection
AbstractPrescription opioid abuse, addiction and overdose are major burdens to patients and society, resulting in significant costs,illnesses, and deaths. The intertwined issues of...
Engaging Vulnerable Women in HIV Prevention and Health Promotion through a Stigma-Reduction Intervention: A Pilot Study
PROJECT SUMMARY This collaborative project between Beijing Normal University, Brown University, and Emory University responds to PAR-23-190 by developing and testing a stigma reduc...
Kupambana: A Combined Microeconomic Strengthening and Stigma Reduction Intervention for Young People with HIV in Zambia
ABSTRACT In low- and middle-income countries, young people with HIV (YPWH) experience the compounded effects of HIV and poverty stigmas that jointly contribute to suboptimal mental...