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Metabolic response to contraction in a 3D engineered muscle tissue model of aging
Title: Metabolic response to contraction in a 3D engineered muscle tissue model of aging Decreased skeletal muscle mass, specific force, increased overall fatty infiltration in the...
Targeting mitochondrial permeability transition to attenuate adverse muscle impact in sepsis
Not only is skeletal muscle a target in sepsis that contributes to worse patient health outcomes, including problems weaning from mechanical ventilation and a greater risk of death...
Place, Stress and Cognitive Status Among Black Men during middle and late life
PROJECT SUMMARY Black men experience extremely high levels of stress from unfavorable social and economic circumstances resulting from structural racism, institutional discriminati...
Constructing Mouse and Human Single-cell Atlas in Autosomal Dominant Polycystic Kidney Disease
In humans, mutations in the PKD1 or PKD2 gene account for about 93% of Autosomal Dominant Polycystic kidney disease (ADPKD) cases, although recent reports highlight that other gene...
An Enriched, Immersive Rehabilitative Environment for Those with Traumatic Brain Injury
PROJECT SUMMARY Severe traumatic brain injury (sTBI) can lead to permanent motor and cognitive deficits and often result in exclusion from participation in society. Recovery of fun...
Optic nerve head metabolic change promotes fibrosis
Abstract Extracellular matrix changes, metabolic reprogramming, glial hypertrophy, axon transport deficit, and inflammation contribute to retinal ganglion cell (RGC) axon loss at t...
Mechanisms underlying the relationship between sleep health and circadian timing with cardiometabolic risk in adolescents with type 1 diabetes
PROJECT SUMMARY Our research has shown a link between poor sleep health and late circadian timing with cardiometabolic dysfunction in adolescents with type 1 diabetes (T1D). Furthe...
Schwann cell Piezo1 and pain sensation
Summary/Abstract Functional Piezo1 is enriched in the Schwann cells (SCs) of the peripheral nervous system; however, whether SCs-Piezo1 contributes to pain pathology is generally u...
5/7-PsycheMERGE: Advancing Precision Psychiatry
PROJECT SUMMARY Psychiatric disorders remain a leading cause of disability in the US and are associated with increased morbidity and mortality. Early detection and treatment is ess...
Defining the modular architecture of protein intrinsically disordered regions for a predictive understanding of biological function
PROJECT SUMMARY/ABSTRACT Protein sequences can be broadly categorized into two classes: those which adopt stable secondary structure and fold into a domain (i.e., globular proteins...
Mechanistic Elucidation of Mitochondrial Stress Response in Human Cells
PROJECT SUMMARY/ABSTRACT Mitochondria play essential roles in eukaryotic cells. However, they are often subject to stress originated from various sources, both intrinsic and extrin...
Reducing Uninsurance by Addressing Administrative Burdens in the Health Insurance Marketplaces
PROJECT SUMMARY/ABSTRACT Over 27 million Americans remain uninsured in 2022, and millions more have lost Medicaid coverage with the end of the Public Health Emergency in 2023. Over...
New Evidence on the Role of Federal Funding in Reducing the Prevalence of Obesity
PROJECT SUMMARY Over the last twenty years, US obesity prevalence increased by over a third, with the prevalence of severe obesity increasing by 96%. Nearly 3 in 4 adults are class...
FMRP regulation of mitochondria and metabolism in mammalian brain development
Neuronal activity is critical for brain development and altered activity-dependent plasticity is found in neurodevelopment disorders. RNA binding protein FMRP, encoded by the X-lin...
Harnessing the Latent Potential of Radical Migration to Drive Synthetic Innovation
Project Summary/Abstract This proposal will exploit the unique and latent features of radical-mediated migrations to underpin new synthetic transformations designed to facilitate t...
Mosaic in Vivo Perturbation (MVP) for systematic assessment of gene function in the eye
Project Summary Genetic screens have been a mainstay of scientific research in animals for over a century contributing immensely to our understanding of molecular cell biology, ani...
Advancing Causal Inference in Integrative Omics Analysis
Project Summary Emerging and rapidly progressing technologies can now measure the molecular phenotypes of genes, transcripts, proteins, metabolites, and gut microbiota. These omics...
Glycemic and Weight Loss Effects of Semaglutide in Subjects After Spinal Cord Injury and Type 2 Diabetes
Patients with spinal cord injury (SCI) develop diabetes at an earlier age and at a much higher rate than able bodied individuals (AB). Those with SCI and T2D are at much higher ris...
Prodrug engineering for enhanced biodistribution and pharmacokinetics
Project Summary Small molecular drugs play a pivotal role in treating a wide range of diseases, such as cancer, infection, cardiovascular diseases, and various other ailments. Howe...
The Penn LungMAP 3 team: Defining chronic lung disease
PROJECT SUMMARY Lung diseases are one of the leading causes of morbidity and mortality worldwide. Chronic Obstructive Pulmonary Disease (COPD) and other Chronic Lung Diseases (CLDs...