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99,167 grants found
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Beyond insulin: Next-generation modulators of insulin receptor for glycemic control
This research project is dedicated to the development and optimization of non-peptide ligands designed to activate insulin receptors, fundamentally transforming approaches to glyce...
Strategies to Improve the Cardiovascular Health of Rural Working-Age Adults in the United States
PROJECT SUMMARY/ABSTRACT In the US, working-age adults (age 20 to 64-years) in rural areas experience significantly higher cardiovascular (CV) mortality rates than their urban coun...
Vestibular implant tested in patients with peripheral vestibular damage: effects on spatial orientation, navigation, and neuropsychologic function
This project will test the capability of a vestibular implant (VI) to improve cognitive dysfunction in patients with severe vestibular damage. We will measure how higher-level beha...
Mechanistic Study of PEG-asparaginase-Induced Liver Injury
Project Summary PEGylated asparaginase (PEG-ASNase) is one of the main drugs used for the treatment of pediatric acute lymphoblastic leukemia (ALL). Although PEG-ASNase is safe and...
Investigating the molecular regulation of cell protrusion function in 3D
PROJECT SUMMARY Cells shape and reshape themselves as they accomplish diverse functions in vivo. These cell shape changes result from physical and chemical feedback loops at multip...
Functional and molecular characterization of Oncofetal Stem Cells in CRC
Functional and molecular characterization of Oncofetal Stem Cells in CRC Project Summary. Background. Colorectal cancer (CRC) is the second most deadly cancer worldwide, with nearl...
Microglial Polarization: Brain Injury or Protection in Response to Intrauterine Infection
PROJECT SUMMARY Neurodevelopmental impairment remains the most vexing issue facing the clinical management of premature infants. Intrauterine infection and inflammation are signifi...
A low cost approach for imaging calcium signals from a large population of neurons
Project Summary Optical recording of calcium transients from large number of neurons is an indispensable technique for comprehending neuronal ensembles during brain processes. Whil...
Romantic Relationships, Discrimination Stressors, and Alcohol Use among Sexual and Gender Minority Adults
Project summary Sexual and gender minority (SGM) adults disproportionately experience the burden of alcohol use. Compared to cisgender straight individuals, SGM adults are more lik...
Role of epigenetic changes in intracellular survival and replication of Legionell pneumophila
1 Legionella pneumophila is an opportunist pathogen that infects an immune-compromised host and causes 2 inflammatory pneumonia in the lungs termed as legionnaire’s disease. L. pne...
Paradoxical role of anti-VEGF therapy in subretinal fibrosis of wet AMD
Project Summary Neovascular age-related macular degeneration (nAMD) with choroidal neovascularization (CNV) is a leading cause of vision loss in elderly Americans and is currently...
Leveraging protein-engineered biomaterials and bioorthogonal chemistries to elucidate the role of non-elastic matrix properties in regulating cell fate
PROJECT SUMMARY Cells are exquisitely sensitive to the mechanical properties of their environment, altering fundamental processes like adhesion, migration, cell division, and cell...
Diabetes Prediction During Pregnancy and In Utero Using Pancreas MRI
PROJECT SUMMARY The pancreas is smaller in individuals with diabetes and individuals at increased risk for developing diabetes, suggesting that small pancreas size may convey risk...
Reveal myeloid cell-mediated targeting through nano-bio interface
Reveal myeloid cell-mediated targeting through nano-bio interface. Project Summary/Abstract Nanomedicine based on ultra-small nanoparticles (usNPs), such as dendrimers, gold NPs, q...
Leveraging Quantitative Imaging from Lung Cancer Screening to Create Tools to Confront COPD
ABSTRACT A fundamental gap exists in our ability to screen for Chronic Obstructive Pulmonary Disease (COPD) that has resulted in widespread delayed diagnosis and underdiagnosis. CO...
Seminal plasma metabolomic signatures, preconception phthalates and reproductive outcomes.
SUMMARY Infertility is one of the most common reproductive health disorders affecting 16% of couples in the U.S. Infertility has been historically treated as a female problem; howe...
Mechanisms and functions of three-dimensional chromatin structures in quiescent cells
Project Summary Though the three-dimensional (3D) organization of chromatin regulates all DNA-dependent processes, determining chromatin mechanisms and functions in cells is challe...
Glycosaminoglycan-enabled technologies to reprogram chronic inflammatory states
PROJECT SUMMARY The severity of traumatic injuries has increased in recent years, resulting in further complications that can impair patient recovery or even result in death. The r...
Modulating T Cell Activation to Combat HIV Persistence
PROJECT SUMMARY Major barriers to HIV cure include functional impairment of virus-specific CD8+ T cells and evasion of immune detection by a reservoir of latently infected CD4+ T c...
Atmospheric transformation of harmful cyanobacterial algae and novel mechanisms of pulmonary toxicity
PROJECT SUMMARY HABs occur when colonies of algae grow out of control and negatively impact ecosystems. These blooms can produce toxins that can have detrimental effects on animals...