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EDGE CMT: Neural cell type evolution in insect retinas
PROJECT SUMMARY (See instructions): Overview: Animal genomes provide instructions for producing an amazing diversity of cell types during development, perhaps especially in the bra...
Integrated PET+DBT for optimization of breast cancer therapy
Building on our previous work, we are proposing an innovative dual-mode breast cancer scanner combining positron emission tomography (PET) and x-ray tomosynthesis (XT). Patient-spe...
Uncovering the Biochemical Mechanisms of Riboregulatory Interaction Involving the Hepatitis C Virus 3'X RNA
PROJECT SUMMARY The hepatitis C virus (HCV) is a nanoscopic lipid-enveloped biological entity. Despite the existence of highly effective treatment plans, this pathogenic particle r...
Novel computational approaches for pharmacogenomics of complex diseases
Summary/Abstract Developing better therapies for complex diseases necessitates comprehensive understanding of intricate pharmacogenomic mechanisms. The explosion of multi-omic data...
Regulation of sperm activation in C. elegans
1 Cell differentiation is accompanied by morphological changes and driven by differential 2 gene expression through transcriptional and post-transcriptional mechanisms. In the post...
Pathways of peroxidation: defining the autoxidation of polyunsaturated fatty acids and the cellular consequences
Project Summary/Abstract Inflammation is a tightly regulated and necessary biological process that protects humans from invading pathogens and repairs tissue following injury. Fail...
Molecular basis for functional S1PR1 antagonists in the treatment of comorbid migraine and temporomandibular disorders
Project Summary/Abstract Overlapping pain conditions greatly exacerbate patients’ pain experience. This includes comorbid migraine and temporomandibular disorders (TMDs), which is...
Development of Acetal Radicals in Organic Synthesis
Project Summary/Abstract The foundation of the Kim Research Group at Temple University is built upon the development of new designer reagents and methods to access high-value carbo...
Biomechanics and Hemodynamics of Human Aorta with Remodeling after Endovascular Repair
PROJECT SUMMARY Type-B aortic dissection is a disease with a tear of the intimal layers of the aorta distal to the aortic arch and separation of the wall layers in the thoracic aor...
Surveillance of drug-resistant bacteria in resource-limited settings: a focus on cost-effective long-read sequencing of eyedrop-associated P. aeruginosa and locally sourced metagenomic samples
Project Abstract: Surveillance of drug-resistant bacteria in resource-limited settings: a focus on cost- effective long-read sequencing of eyedrop-associated P. aeruginosa and loca...
Trans-omics Analysis of African American Deceased Donor Kidneys for Transplant Outcomes.
. Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Kidney-risk variants (KRVs) in the apolipoprot...
Heparan sulfate co-polymerase function and defects in disease
Proteoglycans harboring heparan sulfate (HS) chains are widely found on cell surfaces and in extracellular matrices where they interact with growth factors, receptors, morphogens,...
Roles of Histone lysine demethylases KDM5A and KDM5B in the pathogenesis of Heart failure
Heart Failure (HF) is a multi-faceted syndrome characterized by significant morbidity and mortality. Hereditary cardiomyopathies are common causes of HF - notable among them being...
Nucleophilic Cobalt Photocatalysis and Organic Single-Electron Photoreductants; Two Enabling Approaches for Chemical Synthesis
Nucleophilic Cobalt Photocatalysis and Organic Single-Electron Photoreductants; Two Enabling Approaches for Chemical Synthesis – Project Summary The objectives of this proposal are...
Impact of Exercise Adaptations on the Aging Stem Cell
ABSTRACT Aging causes cellular damage that leads to functional decline, chronic diseases, and ultimately mortality. Stem cell functional impairment or loss is a significant effect...
Structure and Mechanism of Epigenetic Gene Silencing
Project Summary The human body has ~37 trillion cells and over 200 different cell types. Polycomb Repressive Complex (PRC1, PRC2) and DNA methyltransferase 1 (DNMT1) are evolutiona...
Immune cell regulation by swelling-activated ion channels
Project Summary/Abstract Ion channels are proteins that allow the permeation of ions across the plasma membrane. These membrane proteins orchestrate the cellular excitability in ne...
The evolution and genetics of recombination rate variation
PROJECT SUMMARY Meiotic recombination is a fundamental aspect of reproduction in most eukaryotes. Recombination rate, i.e. the number of crossovers per generation, is also a key mo...
Hippocampal and Genetic Mechanisms Underlying Development of Depression in Children at High Family Risk
PROJECT SUMMARY Why do some children at high risk for depression develop a disorder, while others remain psychopathology- free? My ultimate goal is to elucidate the neurobiological...
Rapid, Motion-Robust, and Low-Gadolinium MRI for Pediatric Brain Tumors
PROJECT ABSTRACT MRI is the gold standard for diagnosis, staging, and assessment of treatment response in pediatric brain tumors. Neuro-oncology MRI protocols often take more than...