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99,167 grants found
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Consortium for Translational and Precision Health
The Consortium for Translational and Precision Health (CTPH) will serve as a unique bi-institutional hub for infrastructure, services, community engagement, and workforce developme...
Identifying Needs and Building Research Capacity at an Historically-Black University
Identifying Needs and Building Research Capacity at an Historically-Black University Summary Delaware State University (DSU) is an Historically-Black University with an emerging ex...
Fluorescence lifetime-based tumor contrast enhancement using exogenous probes
Imaging techniques that can enhance tumor contrast against non-specific background can significantly impact diagnostic and surgical applications in oncology. Fluorescence optical i...
Functional convergence following disruption of diverse genes associated with cannabis use and major depression
Project Summary There is strong association between cannabis use and depression and suicide, but the underlying cellular links are poorly understood. This presents a challenge for...
Pathophysiology of Chronic and Delayed Mustard Gas Keratopathy
Abstract This is an application to the Countermeasures Against Chemical Threats (CounterACT) NIH-wide program part of the Chemical Countermeasures Research Program. Sulfur mustard...
Understanding the mechanisms involved in HIV-1 CNS latency
In people with HIV (PWH), infected cells persist in several tissue compartments, including brain and lymphoid organs, and can remain indefinitely during combination antiretroviral...
OPC SURVIVOR: Optimizing OroPharyngeal Cancer SURVIVORship
ABSTRACT: OVERALL Oropharyngeal cancer (OPC) is rising in epidemic proportions, largely owing to rise in highly curable oncogenic human papillomavirus (HPV) attributable disease. H...
Core A: Administrative
ABSTRACT: CORE A (ADMIN) The Administrative Core proposes to provide centralized administrative management and strategic oversight of integration of the OPC-SURVIVOR Program. The a...
Project 1: OPC-ORN
ABSTRACT: PROJECT 1 (OPC-ORN) Current standard-of-care external beam radiotherapy (EBRT) for human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) offers high cure at th...
Project 2: OPC-NERVE
ABSTRACT: PROJECT 2 (OPC-NERVE) While most patients with oropharyngeal cancer (OPC) present with near normal functioning at the time of diagnosis, a growing number of survivors suf...
Project 3: OPC-RAD
ABSTRACT: PROJECT 3 (OPC-RAD) Modern-day X-ray–based radiation therapy (IMRT), given with chemotherapy, has improved survival outcomes for patients with oropharyngeal squamous cell...
Core B: Clinical Informatics & Analytics
ABSTRACT: CORE B (CLINICAL INFORMATICS & ANALYTICS) The central hypothesis of this proposed OPC-SURVIVOR P01 is to improve lifelong quality of life (QOL) and health among oroph...
Core C: Patient-Reported Outcomes & Function (PROF)
ABSTRACT: CORE C (PROF) Based on over 8-years of successful longitudinal, prospective patient-centered outcomes data collection in oropharynx cancer (OPC) survivors supporting data...
Mechanism of extracellular electron transfer in Gram-negative bacteria
Toxic contaminants, such as heavy metals and organic compounds, pose serious health threats to sur- rounding communities. Bioremediation, which uses living organisms such as bacter...
Defining Relationships of Early Mediators and Moderators of Sleep (DREAMS)
PROJECT SUMMARY/ABSTRACT Major causes of sleep deficiency affect around 40% of children at some point and 11% through adulthood. Causes of pediatric sleep deficiency are defined by...
Integrating Experimental and Computational Models to Study the Prefrontal Microcircuit Changes During Aging and Alzheimer's Disease
The overarching goal of this proposal is to determine and predict microcircuit changes in the prefrontal cortex (PFC) during healthy aging and disease progression in Alzheimer’s di...
Comparative analyses of somatic mutational processes in primates across lifespans
Project Summary Abstract The vast diversity in lifespans among organisms provides a remarkable natural experiment in which to explore the evolutionary innovations that have shaped...
Inhibiting beta-adrenergic and COX-2 signaling during the perioperative period to reduce ovarian cancer progression
Inhibiting beta-adrenergic and COX-2 signaling during the perioperative period to reduce ovarian cancer progression Abstract: The short perioperative period, days before and after...
Investigating the aggregation of amyloid β during metabolic stress using multiscale modeling
PROJECT SUMMARY The oligomeric forms of two amyloid β (Aβ) peptides, Aβ40 and Aβ42, are considered as the primary toxic agents in the etiology of Alzheimer’s disease (AD). However,...
Exploring the differential spreading of distinct pathological conformers of AD/LBD-related proteins by combining mathematical modeling and functional study
Project Summary Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) are characterized by the deposition of pathological proteins, such as pathological...