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99,167 grants found
Showing 2,441 – 2,460 of 99,167 grants
Long-term Impact and Value of Infant Genomic Sequencing (LIVING)
PROJECT SUMMARY/ABSTRACT The use of genomic sequencing at birth to inform the ongoing care of children has generated great enthusiasm. Genomic sequencing can act as a screening too...
Social Genomic Mechanisms Linking Structural Racism, Perceived Discrimination, and Breast Cancer Survival
PROJECT SUMMARY Women living in historically redlined neighborhoods impacted by structural racism and discrimination (SRD) have shorter breast cancer (BCa) recurrence-free survival...
Understanding Racial/Ethnic Disparities in Clinician Concordance with Hypertension Treatment Guidelines and Blood Pressure Control
Project Summary/Abstract Despite an equal hypertension treatment rate between Blacks and Whites (79.7% vs. 79.1%), racial/ethnic disparities in blood pressure (BP) control persist...
Evolved Molecules that Destroy Cancer Relevant Proteins
ABSTRACT Cancer research is often driven by hypotheses that postulate that a specific protein is important for the disease, hypotheses often tested by adding an antibody to that sy...
Wastewater surveillance to enhance the public health response to HIV and TB in Eswatini
PROJECT SUMMARY Eswatini was among the first countries to achieve the UNAIDS 95, 95, 95 targets resulting in substantial declines in HIV incidence and TB prevalence. Despite this a...
Resolving transcription factor target search mechanisms
Project Summary Proper gene expression regulation is pivotal for cellular function, and its dysregulation contributes to disease. Transcription factors (TFs) initiate gene expressi...
Bio-orthogonal Mid-Infrared Photothermal Imaging of Cancer Metabolism
Project Summary Understanding how cancer cells reprogram their metabolism and interact with other biological processes to gain aggressiveness and/or resistance to a treatment is of...
Activity Probes to Guide Precision Microbiome Therapy
The microbiome has emerged as a functional microbial organ system that plays a key role in human health and disease including obesity, cancer, and inflammation. Dietary and host fa...
The Role of the Macrophage in Bacterial Vaginosis Mediated HIV Risk
Project Summary/Abstract BV is driver of the HIV epidemic, increasing HIV risk up to 60%. Bacterial Vaginosis (BV) is the most common vaginal condition among women of reproductive...
Quantification of molecular interactions across the matrix spectrum enables cancer research.
Project Summary We propose to further develop, refine, and validate our emerging free-solution assay (FSA) technology and our relatively new compensated Interferometric reader (CIR...
TARGETING SIGNALING BETWEEN GLIOBLASTOMA AND THE SUBVENTRICULAR ZONE NICHE
TARGETING SIGNALING BETWEEN GLIOBLASTOMA AND THE SUBVENTRICULAR ZONE NICHE Glioblastoma (GBM) is the most malignant and proliferative primary brain tumor in adults. It remains a th...
Multiplexed, Continuous Reporting of Gene Expression via CRISPR-mediated Transcriptional Activation
PROJECT SUMMARY: Although the detection of gene expression by quantitative PCR, bulk or single cell RNA sequencing represents a cornerstone of biological inquiry, these approaches...
Cellular Mechanisms of Lysosomal Damage Response
PROJECT SUMMARY Lysosomes are essential membrane-bound organelles that play a vital role in cellular degradation and signaling. Damage to lysosomes can be triggered by numerous phy...
Therapeutic Targeting of Mitochondria in Uromodulin-Associated Chronic Kidney Disease
Uromodulin (UMOD)-associated chronic kidney disease (CKD), or autosomal dominant tubulointerstitial kidney disease caused by UMOD mutations (ADTKD-UMOD), is characterized by progre...
Epigenetic mechanisms in a novel model of FSGS
Focal segmental glomerulosclerosis (FSGS) is a pathologic descriptive diagnosis of glomerular scarring (fibrosis). Many types of kidney injury including inherited mutations, drug t...
Artificial thymic organoid platform to study T cell development and HIV/SIV infection using SIV/macaque model of HIV/AIDS
PROJECT SUMMARY Functional CD4+ T lymphocytes are progressively lost during HIV/Simian Immunodeficiency Virus (SIV) infection and must be continuously replaced. Hematopoietic stem...
Improving hypertension care for persons with HIV in Indiana: a participatory agent-based model
ABSTRACT Cardiovascular disease (CVD) has become a leading cause of morbidity and mortality in persons with HIV (PWH). Although clinical guidelines recommend detecting and addressi...
INcentives and ReMINDers to Improve Long-term Medication Adherence (INMIND)
Project Summary/Abstract Globally, 75% of people living with HIV (PLWH) are receiving antiretroviral therapy (ART), but only 67% of them are virally suppressed, with ART medication...
Intra-graft C1 esterase inhibitor therapy for deceased kidney transplantation
Kidney transplantation is the optimal therapy for end stage kidney disease (ESKD) but current transplant outcomes are suboptimal, particularly for recipients of organs obtained fro...
NUCATS CTSA UM1 at Northwestern University
PROJECT SUMMARY/ABSTRACT Over prior funding cycles, the Northwestern University Clinical and Translational Sciences (NUCATS) Institute has developed and delivered a robust institut...