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99,167 grants found
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Contribution of vestibular dysfunction and its central multisensory integration to imbalance in aging
Project Summary The primary contributors to age-related imbalance remain poorly understood because nearly all contributors to balance deteriorate with age, including sensory inputs...
Investigating the Pathogenic Role of Tubulin Post-translational Modifications in CIPN
SUMMARY Chemotherapy induced peripheral neuropathy (CIPN) is the most prevalent neurological complication of oral or intravenous chemotherapy. Approximately 50–90% of patients unde...
The role of acute excitation of sensory neurons in the development of paclitaxel-induced peripheral neuropathy
Project summary/Abstract: Paclitaxel-induced peripheral neuropathy (PIPN) and associated neuropathic pain is a significant adverse effect experienced by cancer patients who receive...
Redox Signaling and AMPK Crosstalk on Alcohol-Induced Multi-Organ Damage: Liver and Adipose TIssue
The goal of the application is to define the interaction among superoxide dismutase 1 (SOD1), adenosine monophosphate-activated protein kinase (AMPK), and catalase in modulating li...
Mechanisms of endocrine therapy and radiation synergism to decrease brain metastases
PROJECT SUMMARY The increasing number of young women diagnosed with metastatic breast cancer has awakened the urgency to define why they are more likely to suffer from aggressive b...
Mitochondrial metabolism controls alveolar epithelial cell fate
PROJECT SUMMARY/ABSTRACT Patients with severe pandemic SARS-CoV-2 pneumonia suffered damage of alveolar epithelial cells due to direct viral injury, subsequent immune response, and...
COVID-19 and the Health and Wellbeing of Vulnerable Service Sector Workers across the Life Course
ABSTRACT The COVID-19 pandemic precipitated intermingled health and economic shocks, which were felt deeply in the service-sector. The service-sector workforce is large, with nearl...
Neural Substrates of Word Retention and Generalization in Toddlers
PROJECT SUMMARY Infants and young children amass a vocabulary at a remarkable pace during the first 3-years. The size of vocabulary, and the rate of its growth predict future outco...
Nef in impaired efferocytosis: a novel mechanism for vascular disease in HIV
Project Summary Anti-retroviral therapy (ART) has protected many HIV patients against the development of AIDS. HIV infection has become a treatable disease. Increased risk for athe...
Combining rTMS & aerobic exercise to treat depression and improve post-stroke walking (RESTORATION)
Project Summary Depression is the most common neuropsychiatric manifestation following stroke and current treatments are largely ineffective. Depression has both direct and indirec...
Pathoadaptive Modulation of Porphyromonas gingivalis Lipopolysaccharide Structure and Function
Project Summary Periodontitis is a polymicrobial-driven and prevalent inflammatory disease of the tissues supporting the teeth in adults. Studies revealed highly active biosynthesi...
Image-guided robotic assistance to improve precision and reduce x-ray dose in orthopedic surgery for pediatric SCFE
Project Summary Placement of orthopaedic implants, such as guidewires and screws, is a common surgical task, and accurate placement is critical to the success of a range of orthopa...
Assessing Metals and Flame Retardant Exposures on Solid Waste Workers
Abstract The US solid waste industry employed approximately 433,000 workers in 2022, in various roles including waste collection, sorting, recycling, processing, and disposal. Thes...
Towards a Comprehensive, Spatiotemporal Roadmap of Cancer Metastasis
PROJECT SUMMARY Cancer metastasis, which accounts for 8 million deaths worldwide annually, is a multistep process that includes the emergence of metastatic subclones in primary tum...
Deep-tissue targeted molecular imaging with a palette of NIR-II emissive DNA-stabilized nanoclusters
Project summary/abstract Advances in in vivo biomedical imaging are critical for revolutionizing the ability of researchers and clinicians to peer inside the living body. These adv...
Translaryngeal Vibration for Hyperfunctional Voice Disorders
PROJECT SUMMARY / ABSTRACT High-quality research designs have demonstrated that voice therapy has a positive impact on hyperfunctional voice disorders associated with muscle tensio...
Leveraging video logs as a bridge to pre-exposure prophylaxis (PrEP) with tailored messaging to Black women and their healthcare providers in Texas
Abstract Achieving the nation’s Ending the HIV (EHE) Epidemic plan goals will require a significant increase in access to and uptake of pre-exposure prophylaxis (PrEP) among cisgen...
Commercial fishing vessel stability and primary prevention policy
Over the last 30-years, safety and health knowledge has increased and helped reduce fatali�es through secondary preven�on a�er vessel casualty occurs, yet vessel instability at sea...
Developing Hyperpolarized Gas MRI signatures to detect and manage acute cellular rejection
ABSTRACT Lung transplantation (LT) is the only definitive therapy for many patients with end-stage lung diseases, but many LT recipients experience allograft failure with high morb...
Defining the landscape of bacterial-colonized microniches in tumors and their role in intratumoral heterogeneity.
PROJECT SUMMARY/ABSTRACT Within a patient’s tumor, malignant cells are surround by a complex and dynamic collection of cell types, which includes the intratumoral microbiota. Howev...