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99,167 grants found
Showing 2,381 – 2,400 of 99,167 grants
Identifying contributors to racial and ethnic disparities in child occupant safety
Project Abstract The purpose of this K99/R00 Pathway to Independence award is to enable Dr. Sartin to gain the experience and skills necessary to become an independent investigator...
Conjugated bile acids as metabolic mediators between gut and fat tissues
Revised Abstract / SummaryAlthough bariatric surgery is the most effective treatment to promote sustained weight loss and metabolic improvement, they are invasive and can cause sev...
Novel roles of hepatic fatty acid oxidation
Modified Project Summary/Abstract Section The liver is central to mammalian metabolism and plays a critical role in providing fuel to other tissues particularly when food is limiti...
Development of edible sorbent therapies to mitigate dietary exposures to per- and polyfluoroalkyl substances (PFAS)
ABSTRACT Per- and polyfluoroalkyl substances (PFAS), also known as “forever chemicals”, are emerging contaminants of concern due to their prevalence (in 99% of blood samples in the...
Mechanisms of glucocorticoid-induced metabolic dysfunction in skeletal muscle
Abstract/Project Summary Glucocorticoids are commonly prescribed as an essential drug regimen for anti-inflammatory modalities; however, a major side effect of such therapies is th...
Development of a Novel Split Enzyme Diagnostic Platform for Use at the Point of Care
PROJECT SUMMARY Rapid, inexpensive detection of biomarkers at the point of care is vital for many clinical purposes. However, limitations in current detection platforms have preven...
Circular RNAs in Cholestatic Liver Diseases
Primary sclerosing cholangitis (PSC) is a major cholestatic liver disease with high morbidity and mortality. Inflammation and fibrotic injury of the bile ducts due to impairment of...
CORE B: Data Management Core
The overarching goal of our research consortium, entitled "PROVIDENT: PRepositioning Optimized Vaccine strategies and Immunotherapeutics against Diverse Emerging iNfectious Th...
CORE C: Structure & Protein Engineering Core
For pandemic preparedness, structural biology and structure-based vaccine design are critical to the prototype pathogen approach. Vaccine developers must select the viral protein(s...
CORE D: Animal Models and In Vivo Evaluation Core
In vivo efficacy testing is essential for the down-selection, evaluation, and development of potent and effective medical countermeasures (MCMs), especially given that many aspects...
CORE E: RNA Manufacturing Core
PROJECT SUMMARY RNA vaccines have quicker development timelines and are simpler to manufacture than traditional vaccines. Combining this strength of RNA technology with protein eng...
Research Project 1: Discovery and dissection of virus-host interactions and pathogenetic mechanisms
Viruses interact with and hijack a vast array of cellular molecules and pathways to facilitate their multiplication and spread, while also reprograming infected cells to release pa...
Research Project 2: Antigen design and immunological evaluation
In Project 2 (P2) we will use cutting-edge antigen engineering to refine vaccine antigen design strategies through iterative assessments of immunogenicity and protective efficacy t...
Research Project 3: Rapid-Response Roadmap for RNA vaccines
Abstract RNA vaccines have dramatically altered the landscape of vaccine development, affording an unparalleled ability to rapidly counteract emerging infectious diseases, as evide...
Research Project 4: Mining human antibody responses to inform vaccine and therapeutic design
Abstract: This proposal embodies the development of an advanced platform for rapid identification, characterization, and optimization of monoclonal antibodies (mAbs) to effectively...
Identifying Targets for Fall-prevention Rehabilitation in People with Parkinson’s Disease
PROJECT SUMMARY The long-term goal of this line of research is to improve physical therapy for fall prevention in people with Parkinson’s disease (PD). Falls place an enormous burd...
Multi-scale modulation of organ adaptation
Organs modulate their functions and forms to adapt to changing physiological needs and external stimuli. Current understanding of organogenesis revealed how molecules and cells wor...
A Mobile Web App Intervention to Promote Cervical Cancer Screening among Indigenous Women
Project Summary Our overarching goal is to increase the rates of cervical cancer (CC) screening among Indigenous women in the U.S. This population experiences disproportionately hi...
Novel Econometric Research Designs (NERD) to Help End Addiction Long-term
PROJECT SUMMARY/ABSTRACT Opioid use disorder (OUD) is a public health emergency impacting the lives of an estimated 5.6 million individuals in the United States. OUD is a particula...
A Multilevel Data Analytic Solution to Advance Population Cancer Research
Project Summary/Abstract The proposed work will develop a first-of-its-kind, transportable informatics tool, the Population Cancer Assessment and Surveillance Engine (Pop-CASE), th...