Browse All Grants
99,167 grants found
Showing 221 – 240 of 99,167 grants
A Longitudinal Study of Egyptian Healthy Aging (Al-SEHA)
This project will implement A Longitudinal Study of Egyptian Healthy Aging (“AL-SEHA”) including the harmonized cognitive assessment protocol (HCAP) to measure the prevalence of Al...
Utility of human milk oligosaccharides against the perinatal pathogen, Group B Streptococcus
Project Summary Adverse pregnancy outcomes are a global issue that affects more than 50 million people per year. Infections during gestation contribute significantly to adverse pre...
Cell State Network-Directed Therapy
ABSTRACT—Cell State Network-Directed Therapy Drug resistance is a significant challenge in cancer therapy and has historically been addressed from “one step behind”, whereby drug(s...
Molecular architecture of the human knee joint and pelvis at single cell resolution
Project Summary/Abstract At the cornerstone of human bipedal locomotion are the pelvis and knee, two hind limb skeletal structures for which we know little about their respective d...
A framework for feasible translation to enhance foot and ankle function in aging and mobility
PROJECT SUMMARY / ABSTRACT This supplement will support Ms. Paula Kramer, a doctoral student from an underrepresented minority, to examine how new and modifiable targets to enhance...
Mechanisms driving muscle wasting and adipose tissue loss in the UBF mKO mouse
Project Summary/Abstract Skeletal muscle mass loss during cancer cachexia is one of the most important predictors of poor prognosis and mortality among cancer patients. However, th...
Tendon loading profiles that promote healing in Achilles tendinopathy
PROJECT SUMMARY Mid-substance Achilles tendinopathy is a painful, debilitating, and chronic tendon pathology. Rehabilitation exercises are the first treatment option for patients,...
Exposome Monitoring for Skin Diseases through Liquid Biopsy Multiomics
Project Summary Psoriasis and atopic dermatitis are common, immune-mediated skin diseases that are significantly influenced by environmental factors. Developing remote monitoring t...
Understanding the relationship between individual, social, and structural determinants of health, mobility, and HIV outcomes among adolescents and young adults living with HIV in Tennessee
ABSTRACT Adolescents and young adults living with HIV (AYA-HIV), especially minoritized individuals, face the highest HIV incidence and poorest care outcomes among all age groups o...
Measures of structural stigmatization and discrimination for HIV research with Latine sexual and gender minorities
PROJECT SUMMARY The goal of the proposed research is to develop, validate, and apply measures of state-level structural stigmatization and discrimination (SSD) for Latino/a/e (“Lat...
Decreasing Disparity in Lung Disease: Pulmonary Rehabilitation for Rural Patients with COPD
PROJECT SUMMARY Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Globally, COPD prevalence is estimated to be 11.7%, and COPD i...
Comprehensive functional phenotyping of trigeminal neurons innervating temporomandibular joint (TMJ) tissues in male, female and aged mice, primates, and humans with and without TMJ disorders (TMJD)
Abstract The knowledge of the function, types, distributions, and plasticity of afferent neurites innervating temporomandibular joint (TMJ) tissues is needed to understand the unde...
SELVA: A Multicenter, Phase 3 Baseline-Controlled Study Evaluating the Safety and Efficacy of PTX-022 in the Treatment of Microcystic Lymphatic Malformations
FOA Number: RFA-FD-23-001 FOA Title: Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01) Clinical Trials Required Proposal Title: SELVA: A Multicenter...
Convener and Organizer of Activities and Engagements Related to Processes, Surveillance, and Policy Development of Medical Products for Ongoing Public Health Activities, U01 Clinical Trial Not Allowed
PROJECT SUMMARY The Center for Drug Evaluation and Research (CDER) at the U.S. Food and Drug Administration's (FDA or the Agency) is seeking proposals for collaborative resear...
Functions of LynA and LynB kinases in dendritic-cell pro-inflammatory signaling and lupus
ABSTRACT The Src-family kinase Lyn is critical for maintaining immune homeostasis and protecting against autoimmunity, and deficits in Lyn function are linked to systemic lupus ery...
The role of cellular senescence in skeletal muscle loss and dysfunction
PROJECT SUMMARY/ABSTRACT The objectives of this proposal are to (1) obtain the experimental skills and career training necessary to develop a translational research program investi...
Senescent CAFs in Breast Cancer Progression
Cancer predominantly affects the elderly, with a significant incidence of breast cancer in women aged 50-70. While cell mutations contribute to tumorigenesis, age-related changes i...
Glutamine-driven "bidirectional" metabolism regulates muscle stem cell function
Abstract: Stem cell exhaustion and related metabolic dysfunction are hallmarks of aging, compromising tissue regeneration/renewal leading to eventual loss of tissue integrity and f...
The Human DNA virome: from petabase scale to single-cell resolution
PROJECT SUMMARY At the turn of the millennium, the cost of sequencing one megabase of DNA exceeded 10 million dollars. Today, decoding that same megabase costs less than a penny. T...
Mitigating the statistical bias due to anatomical variation in pediatric fNIRS
Title: Mitigating the statistical bias due to anatomical variation in pediatric fNIRS Abstract: Functional near-infrared spectroscopy (fNIRS) is a non-invasive neuroimaging method...