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99,167 grants found
Showing 2,361 – 2,380 of 99,167 grants
Discovery of Novel Therapeutics for Inflammation Induced Preterm Birth
PROJECT SUMMARY In this K99/R00 Pathway to Independence application, the candidate proposes a structured, rigorous and detailed training plan to build expertise in ex vivo gestatio...
Development of a precision medicine platform for circadian based therapeutics in pancreatic cancer
Abstract Pancreatic ductal adenocarcinoma (PDA) is among the most fatal of all cancers, and is on track to become the second-leading cause of cancer-related death in the US by 2030...
Investigating the role of public transit on health behaviors among older adults with disabilities
PROJECT SUMMARY 11.2 million (23.5%) older adults report difficulty traveling outside their homes, making limited transportation access a structural barrier to health. With over 7...
Characterizing and Predicting Patient Trajectories After Live Discharge from Hospice among Older Adults with Alzheimer's Disease and Related Dementias
PROJECT ABSTRACT Almost half of the 1.7 million hospice enrollees have Alzheimer's disease and related dementias (ADRD) as the principal diagnosis or a comorbidity. Although h...
Ocular mustard keratopathy elicits induced autophagy, which is detrimental to the cornea
PROJECT SUMMARY/ABSTRACT The long-term goal of this project is to understand the pathological mechanisms of sulfur mustard gas keratopathy (MGK) in the cornea. Sulfur mustard (SM)...
Metabolic and epigenetic reprogramming in cyclin E high ovarian cancer
Project Summary/Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA- 24-044”.The ultimate goal of this proposal...
The impact of reduction of cellular senescence on age-related epigenetic heterogeneity
PROJECT SUMMARY Acute myeloid leukemia (AML) occurs mostly in adults 65-years and older and is associated with age-related clonal hematopoiesis (CH). This condition that results fr...
Research Supplement to Promote Diversity in Health-Related Research Parent Project: Effects of Pregnancy and Postpartum Medicaid Dental Benefit Generosity On Use Of Dental Services
Project Summary: The purpose of this pilot study is to explore postpartum women’s oral health knowledge, attitudes, and behaviors (KABs) during and after pregnancy in Florida, and...
Breakthrough Technology to Expedite the Democratization of High Field MRI
ABSTRACT Technology will be developed to enable future compact, mid-field (0.7 Tesla) magnetic resonance imaging (MRI) systems, for improving human health worldwide. MRI is an indi...
Neuroimmune control of lung inflammation
Project Summary: Regulation of immune responses in the lung is a critical determinant of health. While the immune system must respond to viral and bacterial pathogens, these respon...
Mechanistic investigation of human milk feeding on neurodevelopment: a comparative study using neonatal piglets and translatable biomarkers
SUMMARY/ABSTRACT Approximately 10% of all infants are born prematurely, and up to 50% of preterm infants experience neurodevelopmental delays/disorders. Prematurity is associated w...
Synaptic plasticity mechanisms that protect and refine local circuits
ABSTRACT Synapses form trillions of connections between billions of neurons in the brain to establish neural circuits that allow us to sense, think, act, learn, and remember. Our g...
Midlife obesity and prediabetes trigger later life cognitive decline through central nervous system inflammaging and innate immune dysregulation of cGAS/STING
The size of the aging population is reaching record levels worldwide, causing a parallel increase in the number of individuals with cognitive impairment and dementia, including Alz...
The benefits of nicotinamide riboside upon cognition and sleep in older veterans
Project summary/ abstract Candidate: My overarching goal is to promote healthy aging through quality sleep as an independent nurse-scientist. My clinical training in geriatrics and...
Improving alcohol and substance use care access, outcomes, and equity during the reproductive years: A Type 1 Hybrid Trial in Family Planning Clinics
Rates of risky alcohol and drug use and alcohol and substance use disorders (AUDs/SUDs) are highest among women during their reproductive years compared to other periods of the lif...
Effect of IL-21 treatment concurrent to ART and 3HP in Mtb/SIV co-infection
Abstract The global control of TB is compounded by co-infection with HIV. Those infected with HIV are at high risk of reactivating latent TB infection (LTBI). Decades of research h...
Pathogenesis and Outcomes of SARS-CoV-2 In Utero Transmission - Immunologic and Virologic Evaluations
Importance: Despite effective vaccines, SARS-CoV-2 infection remains a major public health problem for pregnant women and their newborns as they have increased morbidity and mortal...
Molecular and functional characterization of olfactory pathways in the arbovirus vector mosquito Aedes aegypti
Project Summary Abstract Mosquitoes infect hundreds of millions of people with deadly pathogens every year. Since mosquitoes identify humans and other important resources primarily...
Examining reproductive and sexual health during the transition to adulthood
Project Abstract Emerging adults attending community college are an underserved population at risk for poor sexual health outcomes. Compared to students at 4-year institutions, com...
Novel Integrative Approach for the Early Detection of Lung Cancer using Repeated Measures
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA- 24-058.” Lung cancer remains the leading cause of cancer-related dea...