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99,167 grants found
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CRCNS: Unraveling the visual system's temporal code for dynamic scene processing
Our brain's ability to instantly recognize an object within a visual scene is almost effortless, yet obtaining this ability in artificial visual systems has taken decades. Thi...
CRCNS: Linking receptorarchitecture and functional brain networks across species
PROJECT SUMMARY (See instructions): Neurotransmitter receptors, varying in distribution across the neocortex, play a crucial role in modulating neural excitability and neural netwo...
CRCNS: Biophysical modeling of axonal morphology and function
PROJECT SUMMARY (See instructions): Intricate cellular morphology is essential for neuron function. Axons in particular form thin and extremely long cables with synaptic contacts a...
CRCNS: Building and testing computational models of the neural basis of natural communication
Communication and language processing disorders can significantly impact the lives of millions of people.The proposed Conversations project will combine an unprecedented ECoG datas...
CRCNS: Investigating the Neurocomputational Mechanisms of Belief Updating
PROJECT SUMMARY (See instructions): Virtually every aspect of human behavior is governed by beliefs about ourselves and the world around us. These beliefs are continuously updated...
CRCNS: Repurposing Transformers to Characterize Gut Microbiome & Aging Brain Axis
For debilitating neurodegenerative diseases such as Alzheimer’s disease (AD), some drugs have been approved but only offer a modest attenuation of cognitive decline. There is a nee...
Application for MFRPs Funding for the Louisiana Department of Health
Project Summary The Louisiana Department of Health is applying for funding under the cooperative agreement with the Food and Drug Administration, Funding Opportunity Announcement (...
Engineering Mucin Analogues to Benefit the Mouth Environment
PROJECT SUMMARY. While artificial saliva products are available in the market, they need to replicate natural saliva's essential protective roles in maintaining a healthy oral...
DDT-BMQ-000146 Assessing clinically meaningful change in PSC as determined by quantitative MRCP (MRCP+) measured number of strictures
Abstract MRCP+ metrics are quantitative markers of the biliary tree which can be used to inform biliary tree health. These markers have shown promise as dynamic biomarkers which ca...
Development of a Qualification Plan for the Virtual Reality Functional Capacity Assessment Tool - Short List (VRFCAT-SLx) (DDT COA #000004)
ABSTRACT Nearly 7 million people in the United States are living with Alzheimer’s disease (AD). As people with AD progress through the stages of this disease, their ability to func...
Psychometric Analyses and Quantitative Study Report for Qualification of the Chronic Heart Failure Symptom Scale (CHF-SS) (DDT COA #000112)
ABSTRACT Heart failure is a major worldwide health problem, with a prevalence of over 6.2 million in the United States (US), and over 26 million worldwide. Heart failure is associa...
DDT-BMQ-000054: Planning for biomarker qualification, implementation and dissemination for BMD as a surrogate biomarker in future osteoporosis treatment trials: the SABRE project
PROJECT SUMMARY Currently approved therapies for osteoporosis can reduce spine fracture risk by 50-75% and hip fracture risk by up to 50%. However, due to fears about very rare sid...
Genetic and Neuronal Mechanisms that Regulate Zebrafish Sleep - DIVERSITY SUPPLEMENT
PROJECT SUMMARY Sleep disorders are pervasive and cost approximately $100 billion a year, yet the mechanisms that regulate sleep are still poorly understood. Previous sleep researc...
The Role of Chibby Family Members in Spermatogenesis and Male Fertility
PD/PI: Takemaru, Ken-Ichi 7. PROJECT SUMMARY Cilia are evolutionarily conserved microtubule-based structures that protrude from the apical cell surface to perform important biologi...
Axonal Transport of mRNA for Mitochondrial Proteins (Diversity Supplement)
SUMMARY Neurons use local translation to preserve the health of axons, dendrites, and synapses that are far from the soma. Local translation allows them to respond to local needs....
Diversity Supplement to R01 Parent Grant HL150624
PROJECT SUMMARY Clonal hematopoiesis of indeterminate potential (CHIP) increases with age and occurs when a single mutant hematopoietic stem cell (HSC) contributes to a significant...
DDT-COA-000167: Digital Sensor for Monitoring Swallow Count and Respiratory Coordination in Parkinson’s Disease patients with Dysphagia
PROJECT SUMMARY: Parkinson’s disease (PD) presents complex challenges, including dysphagia, which affects 33-80% of patients and significantly impacts their quality of life. Dyspha...
DDT-IST-000016-LOI-2 A Human Liver-Chip for Prediction of Drug-Induced Liver Injury proposed for context of use claim for the prediction of DILI within preclinical drug development program
RFA-FD-24-030 Application Identifier: 1690535 Project Summary/Abstract: Drug-induced liver injury (DILI) is a leading cause of post-market drug withdrawal, clinical trial failures,...
Gene Therapy in a GALT-null Rat Model of Classic Galactosemia
Classic galactosemia (CG) is a potentially lethal genetic disease that is one of the most common metabolic disorders identified by newborn screening in the United States.Despite ne...
An automated approach for video-based motor assessment in Parkinson's disease
Project Summary Parkinson’s disease (PD) is neurodegenerative movement disorder that causes a series of motor deficits. Due to the degenerative nature of PD, effective management o...