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99,167 grants found
Showing 2,301 – 2,320 of 99,167 grants
SCH: Machine learning for personalized preventative intervention in perinatal depression
PROJECT SUMMARY (See instructions}: The goal for this project is to develop machine learning (ML) to accelerate the discovery of scalable, interpretable, and personalized preventat...
A longitudinal study of traumatic brain injury in a high-risk population
Contact PD/PI: KIEHL, KENT A Project Summary/AbstractTraumatic brain injury (TBI) is a global public health concern affecting millions of individuals in the United States [1], with...
Diversity Supplement: Cheminformatics-based identification of leukemia-targeting molecules
Contact PD/PI: Kirienko, Natasha V SUMMARY Acute myeloid leukemia (AML) is the most common acute leukemia in the US, with ~20,000 new diagnoses and ~11,000 deaths per year. This pe...
Comprehensive assessment of the diastereomer composition of LEQVIO (Inclisiran) to determine how chemical synthesis impacts biological activity
PROJECT ABSTRACT Nucleic acids are an increasingly popular platform for the development of biotherapeutics to treat and prevent a wide variety of human diseases. The predominate cl...
Local Flavor Policies to Enhance Equity in Tobacco - A Diversity Supplement
ABSTRACT Policies restricting the sale of flavored tobacco products (FTP) are being enacted in localities around the US. We seek to expand the evidence base about the extent to whi...
SCH: Toward a smart, home-use system for noninvasive, personalized monitoring of drug levels
PROJECT SUMMARY (See instructions): To optimize drug dosing, clinicians may order laboratory testing of drug levels in patient blood samples, but the clinical benefit of such testi...
Stigma, Romantic Relationships, and Alcohol Use Among Transgender and Nonbinary Young Adults
PROJECT SUMMARY/ABSTRACT For transgender and nonbinary (TNB) people, anti-TNB stigma is a risk factor for adverse alcohol outcomes, often co-occurring with depression and anxiety....
SCH: Transfer Regression to Enable Cross-Domain Cardiovascular Event Prediction
SCH: Transfer Regression to Enable Cross-Domain Cardiovascular Event Prediction This project proposes fundamental novelties (e.g., transfer volume regression) in computer science,...
The Safety of Switching Between Complex Branded and Generic Drugs: Developing a Semi-Automated Sequential Surveillance System Using Tree-Based Scan Statistics
Drug-device combinations containing active pharmaceutical ingredients marketed together with their delivery devices are among the costliest medications in the US. Generic competiti...
SCH: Efficient Image-based Hemodynamic Modeling via Physics-integrated Bayesian Deep Learning
This project aims to revolutionize cardiovascular research and healthcare by developing an Al-augmented image-based hemodynamic modeling platform. The primary objective is to estab...
SCH: Robust and Equitable Clinical Decision Support in Glaucoma Detection and Progression Prediction
This project seeks to address the pressing issue of vision morbidity and vision impairment caused by glaucoma. Glaucoma, a complex and multifactorial disease that develops over ext...
SCH: A biomechanics-guided wireless ultrasonic e-tattoo with an application specific integrated circuit for ambulatory blood pressure monitoring
Although ambulatory blood pressure monitoring (ABPM) has been used to detect sources of cardiovascular mortality (e.g., hypertension and abnormal BP rhythms) for over six decades,...
Factors related to drug and Formulation affecting alcohol dose dumping in modified release oral drug products
ABSTRACT/SUMMARY Dose dumping, which is defined as ‘‘unintended, rapid drug release in a short period of time of the entire amount or a significant fraction of the drug contained i...
Development of PBPK Model-Based Mechanistic IVIVCs for Long-Acting Injectable Suspensions
SUMMARY/ABSTRACT: Long-acting injectable (LAI) suspensions represent a class of complex drug products administered either intramuscularly or subcutaneously and characterized by dep...
Developing PBPK-model based mechanistic IVIVC for PLGA implants
There is an immediate need to understand the critical formulation parameters that may affect product performance in vitro and in vivo, with a goal of developing IVIVCs for long-act...
From Bench to Bioequivalence: In Vitro Mechanistic Understanding of ASD Drug Products in Simulated Gastrointestinal Conditions
From Bench to Bioequivalence: In Vitro Mechanistic Understanding of ASD Drug Products in Simulated Gastrointestinal Conditions – Project Abstract The findings from this project wil...
ML-CFD-DEM Based Reduced Order Models (ROM) to Quantify Variability in Inhalers, Drugs, and Users for Evaluating Comparability of Generic OIDP Complex Products
PROJECT SUMMARY Ensuring accurate predictions of the transport and deposition of orally inhaled drug products (OIDPs) within dry powder inhaler (DPI) flow channels to the human res...
VENOUS ETHANOL ABLATION IN ISCHEMIC VENTRICULAR TACHYCARDIA- VELVET TRIAL
Abstract Radiofrequency (RF) ablation of ventricular tachycardia (VT) in ischemic cardiomyopathy is fraught with limitations due to suboptimal efficacy, risk of complications, and...
Assessing Parenting at the Momentary Level to Understand Parenting Behaviors that Contribute to Improved Treatment Outcomes for Youth with Co-Occurring Disorders
PROJECT SUMMARY/ABSTRACT. Over 80% of adolescents with an alcohol use disorder (AUD) who present to treatment have a co-occurring psychiatric diagnosis. Although the best available...
Molecular Markers of Cerebrovascular Pathologies in Alzheimer's Disease and Related Dementias
Summary Project Clinical and preclinical studies have demonstrated perturbations to the cerebrovascular network in Alzheimer’s Disease (AD) in sex-specific manner. Altered blood fl...