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The Unilateral Mosaic (UMos): Novel tools to compartmentalize pathology and trace cellular interactions in mouse models of human disease
This project will credential two novel types of broadly applicable mouse models, which we will demonstrate in the lung. First, we will express genes that drive disease susceptibili...
Scalable Expanded Access with Analysis of Neurofilament and Other Biomarkers for Ibudilast in ALS (SEA-NOBI-ALS)
PROJECT SUMMARY/ABSTRACT Current treatment options for amyotrophic lateral sclerosis (ALS) are inadequate, and many patients living with ALS seek access to experimental therapies w...
DMS/NIGMS 2: The mathematics of epigenetic regulation in human cells
A major challenge at the interface of mathematics and molecular and cellular biology remains the development of accurate and predictive models of epigenetic mechanisms. While eukar...
Effects of COVID-19 Related Medicaid Policy Changes in the Marshallese COFA Migrant Population
ABSTRACT Access to healthcare is a persistent public policy concern, particularly for Marshallese Compact of Free Association (COFA) migrants in the United States. This research ad...
Implementation, reach, and impact of court-ordered tobacco corrective statement postings at the point-of-sale
PROJECT SUMMARY/ABSTRACT Tobacco use remains a leading cause of premature disease and death in the United States, including those attributable to cancer. In a landmark racketeering...
Bidirectional effects between adolescent digital dating abuse dynamics and mental health
Project Summary Recent nationally representative data show that 76% of adolescents experience digital dating abuse. Digital dating abuse is the use of technology to threaten, haras...
Clinical Care of Newborns with Prenatal Substance Exposure: A National Study
PROJECT ABSTRACT Perinatal substance use in the U.S. has increased over the past two decades, with now over 8% of pregnant people endorsing recent use of a federally illicit substa...
Developing strategies for implementation and use of the Operating Room Black Box
Project Summary It is estimated that fixing problems related to preventable errors costs the U.S. healthcare system $400 billion annually. In the field of surgery, the most basic e...
IP24-017 - Collaborative research on influenza and other respiratory pathogens in South Africa
PROJECT SUMMARY This project aims to generate a body of data that will result in improved approaches for disease surveillance and prevention and expanded access to interventions fo...
Organizational strategies to support community health center well-being
There are national movements to improve the quality of primary care for patients while protecting and promoting health worker well-being. The critical barrier to realizing these ca...
Recapitulating the native tendon microenvironment through design of degradable, anisotropic engineered extracellular matrices
Project Summary Following injury and repair, tendons rarely exhibit full restoration of function and reinjuries are prominent. Poor clinical outcomes are due to deposition of disor...
Assessing the Impact of Health System Ownership on Fulfilling the Vision of High-Quality Primary Care and Whole Health
TITLE: Assessing the Impact of Health System Ownership on Fulfilling the Vision of High-Quality Primary Care and Whole Health PROJECT SUMMARY The National Academies of Sciences, En...
Measuring the Impact of Price Ceiling Controls: A Case Study of Insulin Out-of-Pocket Caps
PROJECT SUMMARY Over 30 million Americans have type 1 diabetes (T1D) or type 2 diabetes (T2D), a disease with significant effects on morbidity and mortality1 that disproportionatel...
Predict, Detect, Diagnose: Confronting Outbreaks of HIV and Other Infectious Diseases Among People Who Use Drugs
Project Summary There have been numerous outbreaks of human immunodeficiency virus (HIV) among people who use drugs (PWUD) since the well-publicized outbreak in Scott County, India...
Effects of SGLT2 Inhibition on Coronary Flow Reserve and Other Key Indices Relevant to Type 2 Myocardial Infarction Risk among Women with HIV
7. Project Summary/Abstract US women living with HIV (WLHIV) on antiretroviral therapy (ART) face a three-fold risk of myocardial infarction (MI) compared with women without HIV. F...
CDK6-dependent metabolic reprogramming in KSHV pathogenesis
Project Summary Metabolic reprogramming is one of the hallmarks for cancer. Emerging studies show that viral infections induce similar metabolic rewiring for viral persistence and...
Scaling Comprehensively Access to Long-acting for an Effective Use of PrEP (SCALE-UP)
PROJECT SUMMARY Significance. In Africa, AIDS is the leading cause of death among adolescent girls and young women (AGYW). In 2022, 3100 adolescent girls and young women in Africa...
Test-to-PrEP: A Randomized Hybrid Implementation/Effectiveness Trial of a Social Network Strategy to Increase Equitable Reach of HIV Testing and PrEP Information
Abstract/Project Summary For this project, we propose a type 3 hybrid implementation-effectiveness randomized controlled trial (RCT) comparing two strategies that engage the social...
Environmental forces shape the ecology of virulent parasites in coastal ecosystems
Few studies have characterized disease ecology questions for pathogens with robust environmental stages that cross ecosystem boundaries. In recent decades, terrestrially derived pr...
Developing a Telehealth + mHealth Cannabis Use Intervention for Young Adults (MOMENT-V)
PROJECT SUMMARY/ABSTRACT Daily cannabis use among young adults aged 18-26-years is at historically high levels and >4.8 million young adults meet criteria for cannabis use disor...