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99,167 grants found
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Effect of Ubiquitin D variants upon APOL1-mediated kidney injury
PROJECT SUMMARY Despite the success of antiretroviral therapy in improving mortality, persons with HIV (PWH) have shortened lifespan and increased prevalence of non-infectious dise...
Persistent oral HPV among diverse PLWH: A pilot study to evaluate the feasibility and acceptability of testing for oral HPV DNA infection with mail-delivered sample collection kits.
PROJECT SUMMARY People living with HIV (PLWH) have an estimated 1.6-6.0 times increased risk of developing oropharyngeal cancer (OPC) compared with individuals in the general popul...
Neuronal mechanisms underlying training-induced vision recovery
Occipital strokes cause permanent damage to primary visual cortex (V1), the gateway for visual information processing in humans. Such patients lose conscious vision in the contrala...
Integrative multi-omics for discovery of molecular pathways associated with diabetic retinopathy
PROJECT SUMMARY One of the areas of emphasis on the NEI strategic plan is to bridge the gap between genomics and mechanisms of disease. Diabetic retinopathy (DR) is a leading cause...
Single cell analysis of healthy and diseased temporomandibular joint synovial fluid
Project Summary/Abstract Temporomandibular joint disorders (TMJDs) are a set of complex, poorly understood painful conditions that profoundly impact the quality of life of many chi...
Pharmacological targeting of nascent modulators of opioid signaling
PROJECT SUMMARY Opioids exert a plethora of behavioral effects that include clinically beneficial analgesia and untoward euphoria that leads to their abuse. Furthermore, prolonged...
Therapy for Non-Hodgkin lympoma
Abstract Viruses are the etiological agents of a number of different human cancers. Epstein-Barr virus (EBV) is a ubiquitous pathogen infecting over 95% of the human population wor...
Complexity, Incidence, and Costs Related to Delayed Diagnosis of Venous Thromboembolism in Urban and Rural Primary and Urgent Care Settings
ABSTRACT Venous thromboembolism (VTE), consisting of pulmonary embolism and deep vein thrombosis, is a common and consequential public health problem affecting up to 600,000 adults...
An infection prevention dilemma: should we place patients with C. difficile colonization on contact precautions?
Project Summary - Clostridioides difficile is a leading cause of infectious diarrhea and the most common cause of healthcare-associated infection (HAIs) in the US, resulting in >...
Predictors of variable language development in autism
Project Summary Impairments in language development are common in children with autism and can have a profound influence on their future developmental outcomes and quality of life....
Reducing Necrotizing Enterocolitis Disparities with a Neonatal Project ECHO
ABSTRACT Despite the widespread availability of low-cost, evidence-based preventative strategies like human milk feeding, feeding guidelines and medication stewardship, necrotizing...
Concentration Determination of Tulathromycin Residues (CP-60,300) in Liver and Injection Site Tissues of Goats Receiving One Subcutaneous Injection of DRAXXIN 25 (25 mg/mL) at 2.5 mg/kg Bodyweight
PROJECT SUMMARY This project aims to address the significant problem of bacterial pneumonia in goats, which is a major cause of morbidity and mortality and represents a significant...
Early Predictors of Late Talking: EEG Trajectories and Psychosocial Profiles
PROJECT SUMMARY Primary language impairment (PLI) affects 6-8% of children in the U.S. and the longer it goes undetected or untreated, the greater the negative cascading effect on...
Leveraging a Unique Dataset to Identify Outcome Predictors in Late Talkers
Late talking in toddlers is not only a common reason for pediatrician concern and referral for developmental evaluation, but it can be a precursor of either persistent language dis...
Characterizing Late Talker Communication with Black Caregivers
Project Abstract Black children are at risk for misdiagnosis across categories of disability due to inappropriate assessment materials and clinicians’ lack of knowledge regarding B...
Advancing Identification of Late-Talking Children and Mapping their Developmental Trajectories Using Real World Data from Electronic Health Records
Late language emergence (late talking), affects one in five children in the United States today. Therefore, a question pediatricians often face at the 24-month well child visit is...
Deciphering mechanobiology in human diseases by developing a TMEM63B channelopathy mouse model
SUMMARY Cells rely on precise sensing and prompt responses to mechanical and osmotic changes to maintain functionality and survival. Recent breakthroughs, including the identificat...
Neuroimmune pathways linking chronic psychosocial stress to co-occurring stimulant use and depression in HIV disease: a mechanistic clinical trial
People with HIV (PWH) who use stimulants experience profound intersectional stigma and discrimination that can cause considerable psychosocial stress. An overactive, unresolved str...
RFA-IP-24-046: Nationwide Cohort of Blood Donors to Estimate Burden of Respiratory Viruses and Immunologic Response
PROJECT SUMMARY/ABSTRACT The program consortium, led by Vitalant Research Institute (VRI), is comprised of the American Red Cross (ARC) and Vitalant (VTL), the two largest US Blood...
Modernizing, Expanding, and Measuring the Impact of FDA Food Safety Initiatives
Project Summary: Modernizing, Expanding, and Measuring the Impact of FDA on Food Safety Initiatives In this CoAg we plan to take advantage of the alternative technologies developed...