Browse All Grants
99,167 grants found
Showing 2,241 – 2,260 of 99,167 grants
ACTIVE MIND: An adaptive clinical trial of cognitive training to improve function and delay dementia
PROJECT SUMMARY Dementia such as Alzheimer's disease (ADRD) is the most expensive medical condition20 in the US and affects more than 5 million Americans21. Analyses from the...
Mechanistic investigation of therapies for Down Syndrome Regression Disorder
PROJECT SUMMARY. Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is a leading cause of intellectual and developmental disability, with an estimated prevalence...
SARS-CoV-2 Serological Antibody Testing for Disease Surveillance and Clinical Use
Abstract Serologic testing for presence of SARS-CoV-2 antibodies is a critical tool for understanding the epidemiology and designing control strategies for the COVID-19 pandemic. O...
3D Shearwave Elasticity Biomarker Development for Neuromuscular Disease
Elasticity imaging techniques generate quantitative measurements of the biomechanical properties of tissue that serve as biomarkers for disease presence as well as enabling the cha...
α-Synuclein Regulation of the Erythroid Iron Restriction Response
(PLEASE KEEP IN WORD, DO NOT PDF)The erythroid iron restriction response suppresses erythropoiesis during iron deprivation and leads to iron deficiency anemia (IDA), one of the mos...
Role of UPR transducer Xbp1 in Pancreatic Beta Cell Survival and Function under Metabolic Stress
Diabetes is now a global epidemic. More than 95% of diabetes is type 2 diabetes (T2D), a chronic disease that can cause serious complications, including heart attack, stroke, kidne...
Neurobiological Basis of Reference Frame Coordination for Spatial Memory to Action Transformations
PROJECT SUMMARY/ABSTRACT Guiding movements through space and establishing enduring memories based on such experiences is essential for the survival of all animals including humans....
Experimental Studies of Endoscopic Third Ventriculostomy and Choroid Plexus Cauterization in Hydrocephalus
Hydrocephalus (HC) is a common and debilitating neurological condition affecting up to 1 in 500 individuals. Ventriculoperitoneal shunting (VPS) has been the standard treatment for...
Targeting Oxidized PTP1B for Anticancer Drug Discovery
PROJECT SUMMARY PTP1B, a non-receptor–type oncogenic PTP, also known as PTPN1, is involved in growth factor signaling. The PTP1B gene is frequently amplified in cancers and correla...
Regulation of synaptic activity by mRNA methylation
PROJECT SUMMARY Neurotransmitter release at synaptic terminals is tightly controlled, and its dysregulation has profound consequences for neural circuit activity and disease. Here,...
A Chemical Strategy for Imaging and Manipulating the Brain's Astrocytes
PROJECT SUMMARY The active participation of the brain’s astrocytes in normal and pathological brain function is now well established. Astrocytes adjust synaptic strength, mediate s...
Identifying New Therapeutics and Molecular Mechanisms in Congenital Disorders of Glycosylation.
Glycosylation is an essential biological pathway that involves the post- or co-translational addition of sugar moieties to proteins. Congenital Disorders of Glycosylation (CDGs) ar...
AI-directed discovery of heparanase inhibitors
(PLEASE KEEP IN WORD, DO NOT PDF)Heparanase, an endo-β-D-glucuronidase, is the only known enzyme to cleave the heparan sulfate (HS) side chains of heparan sulfate proteoglycans (HS...
Natural language processing and medical imaging analysis for multi-modality computer assisted diagnosis of ophthalmic diseases
PROJECT ABSTRACT No change since original proposal
Developing and Evaluating Multi-Modal Clinical Diagnostic Reasoning Models for Automated Diagnosis Generation
PROJECT ABSTRACT Diagnostic errors affect 12 million patients in the U.S. and contribute to 80,000 deaths per year. The main causes for diagnostic errors include cognitive biases i...
Elucidation of the mechanisms by which Ms4a genes regulate neurodegeneration in Alzheimer’s Disease and related disorders
Project Summary/Abstract Current therapeutic interventions for treating neurodegenerative disorders, including Alzheimer’s Disease (AD), frontotemporal dementia (FTD), multiple scl...
Enhanced intratympanic delivery of therapeutics to treat and prevent hearing loss using nanovesicles in the porcine model
PROJECT SUMMARY My long-term goal is to help develop and deliver regeneration therapeutics useful for the clinical treatment of hearing loss. Unfortunately, at this time there is n...
In vivo chemical changes of contemporary polyethylene in TKA: implications for wear and osteolysis
This proposal addresses the unmet need that the mechanisms governing in vivo chemical changes of total knee arthroplasty (TKA) tibial liners are not known. Our objective is to dete...
Mid-sized GDNF Minics for Neural regeneration
Project Summary Repair of traumatic injuries relies upon glial cell line-derived neurotrophic factor (GDNF), and related extracellular cytokines collectively called GDNF family lig...
Sex differences in modulating HIV/SIV reservoirs in the context of opioids
Abstract Due to the widespread use of antiretroviral therapy, HIV replication is effectively controlled in infected individuals. However, viral reservoirs form early post-infection...