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99,167 grants found
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Developing a Two-way SMS Platform to Prevent and Treat Wasting Among HIV-infected and HIV-exposed Uninfected Children
PROJECT SUMMARY/ABSTRACT Twenty-five percent of children with HIV-infection have childhood wasting (low weight-for-height or low mid-upper arm circumference, and HIV-exposed uninfe...
The role of the transcriptional repressor ZEB2 in human neural crest cell formation and craniofacial pathology
Project Summary The objective of this proposal is to delineate the role of the transcriptional repressor ZEB2 during human neural crest cell formation, craniofacial differentiation...
Mechanisms of Impaired Epithelial Regeneration and Fibrosis After Silica Dust Inhalation
PROJECT SUMMARY Silicosis and asbestosis are progressive fibrotic lung diseases causing respiratory failure. Effective therapies are inadequate in large part due to our limited und...
PM2.5 Metals, Oxidative Potential, Exposure, and Risk Assessment (PM OPERA): A National Morbidity and Mortality Study
Project Summary Outdoor fine particulate air pollution (PM2.5, particles with aerodynamic diameter < 2.5 𝜇m) is a leading cause of global morbidity and mortality, contributing t...
Xanthine oxidase mediates the vascular dysfunction with direct and in-utero electronic cigarette exposure
ABSTRACT The adult prevalence of Electronic cigarettes (Ecigs) is ~5%, with young adults having the highest prevalence, and 56% of the young adults were never smokers, which includ...
Leveraging biomarkers for personalized treatment of alcohol use disorder comorbid with PTSD
Project Summary/Abstract Alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) are highly comorbid, presenting a clinical challenge with limited treatment efficacy....
Metal-Mediated C-H Radiofluorination for Rapid Access to PET Imaging Agents
Project Summary/Abstract Fluorine is an essential constituent of many commercial molecules, including (radio)pharmaceuticals, agrochemicals, and functional materials. Fluorine-19 (...
TAZ-driven Regulation of Tumor Microenvironment in Triple-Negative Breast Cancer
ABSTRACT Breast cancer (BC) is a complex and heterogeneous neoplastic disease with a high incidence and mortality. BC can be divided into clinical, histopathologic, and molecular s...
Triclosan, pubertal hormones, and the gut microbiome: implications for neurobehavior
PROJECT SUMMARY Despite potential lifelong consequences of gut microbiome dysbiosis, little is known about environmental factors that influence its diversity and composition, inclu...
Deep-learning assisted photoacoustic histology for real-time intraoperative pathological diagnosis
Project Summary Despite the advances in cancer treatment, surgery remains the cornerstone, and more than 80% of cancer patients have a surgical procedure at some point in their can...
Differentiating the Physiological Sources of Modulated Voice
Project Summary Essential tremor (ET) is the most prevalent movement disorder affecting approximately 25 million people worldwide. Up to sixty-two percent of patients with ET devel...
Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)
PROJECT SUMMARY/ABSTRACT This proposal aims to leverage and enhance existing resources to create a robust, interoperable set of CDEs that will facilitate better understanding, char...
Immune and transcriptomic biomarkers of progressive oral premalignant lesions
PROJECT SUMMARY Oral squamous cell carcinoma (OSCC) is the 6th leading cause of cancer-related mortality worldwide. OSCC is curable with favorable survival outcomes if detected ear...
Impact of Historically Black Colleges and Universities on Late-life Cognition in Black Adults
PROJECT SUMMARY/ABSTRACT Black-White inequities in Alzheimer’s Disease and Related Dementia (ADRD) are a pressing public health problem: prevalence is almost double for Black adult...
Respiratory Effects, Metal and Aldehyde exposure from e-cigarette use in young adults (REMA)
PROJECT SUMMARY My long-term goal is to become an independent investigator focusing on how pollutant exposures may adversely affect respiratory health and identify measures to effe...
Defining the molecular basis controlling hematopoietic stem cell symmetric and asymmetric divisions
PROJECT SUMMARY AND ABSTRACT Hematopoietic stem cells (HSCs) maintain blood homeostasis through a delicate balance in fate choices of self-renewal and commitment to differentiation...
Human genetic studies to solve the etiology of congenital obstructive uropathy and its subphenotypes
Congenital anomalies of the kidney and urinary tract (CAKUT) represent highly understudied conditions, but have tremendous impact on patient morbidity and mortality. Among CAKUT ca...
Leveraging a unique dog model to determine the role of uromodulin in kidney stone disease
Kidney stones are a painful and common health problem, occurring in 8-12% of the population. Most kidney stones are composed of calcium oxalate (CaOx). Current therapies to prevent...
Balancing motivation through VTA GABA/Glutamate co-transmission
Project SummaryUpdates: I am moving to a new position at Dartmouth College as an independent, tenure-track Assistant Professor in the Department of Psychological and Brain Sciences...
Neonatal Stress in Very Preterm Infants: Longitudinal Effects on Epigenetics and Neurodevelopment
PROJECT SUMMARY (See instructions): Preterm birth affects 1 in 10 infants born in the United States, resulting in significant morbidity and economic cost. Children who are born ver...