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99,167 grants found
Showing 2,201 – 2,220 of 99,167 grants
Role of altered gut immune response in Lewy Body Disease
PROJECT SUMMARY/ABSTRACT Lewy Body Diseases (LBD), which include Parkinson's Disease (PD) and dementia with Lewy bodies (DLB), represents a spectrum of progressive, debilitati...
Design of a Lay Health Worker Training Intervention to Promote Mental Health Care Access for Racially Diverse Transgender Youth
PROJECT SUMMARY Transgender youth face a high risk for serious mental health problems (e.g., suicidality, depression, anxiety) relative to cisgender youth due to their disproportio...
Connecting across Scales: Integration of Cell-Specific Microstructure within Long-Range Brain Networks in the Macaque Monkey
Project Summary Structural alterations in brain networks are driven by changes in cortical microstructure, including neuronal death, the disappearance or rewiring of a synapse, and...
Chronic alcohol effects on the biogenesis, distribution, and RNA content of astrocytic exosomes
PROJECT SUMMARY/ABSTRACT Neuronal dysfunction underlies the general pathophysiological mechanisms related to heavy alcohol use and development of alcohol use disorder (AUD). Homeos...
Upregulating spinal circuits to enhance balance and walking and to increase spinal excitability in older adults
PROJECT SUMMARY/ABSTRACT A high proportion of older adults are currently or soon will be at risk for the well-known decline in walking and balance abilities that occur with aging....
Airway distensibility and lung inflation effects on the maximal expiratory flow volume curve in elderly adults
PROJECT SUMMARY Both the total number of elderly persons and the incidence of lung disease will increase in the coming decades. It is vital that we define the normal physiological...
Predictive Factors in Language Development Trajectories Over the First 3 Years of Life: Harnessing an Existing Preterm Cohort
ABSTRACT In utero, organized and predetermined patterns of auditory structural and neural pathway development set the stage for early language acquisition.15 The very low birth wei...
IMAT-ITCR Collaboration: Multiplexed Spatial Data Calibration and analysis using micro-capsules
Project summary A major goal of cancer research is to define the composition of the tumor micro-environment (TME) across individuals. Once measured, differences in TME composition...
Cr(VI) exposure and skeletal muscle differentiation and regeneration
SUMMARY Hexavalent chromium, Cr(VI), is widely used in industrial processes such as stainless steel production, electroplating, textile manufacturing, wood preservation, and leathe...
Elucidating the role of the hyaluronan matrices on the establishment of ovarian reserve and aging
ABSTRACT In mammals generally, including humans, the ovary ceases its functions little more than halfway through a female's lifespan. This is strikingly different from the cha...
Reversing disrupted developmental sterol biosynthesis by prescription medications
Compound heterozygous mutations of the DHCR7 gene give rise to a developmental disorder known as Smith- Lemli-Opitz syndrome (SLOS). The loss of DHCR7 function in these patients di...
Pathogenesis of oral microbes triggered by the cyclic deformation of biomaterials
PROJECT SUMMARY Oral pathogenic biofilms are major drivers of major oral infectious diseases such as dental caries and denture stomatitis. Currently, the annual cost of treatment o...
FullMouth: Enhancing Dental Clinical Data and Reducing Disparities through Innovative ML Approaches.
Project Abstract/Summary The vast amount of health data created in the United States may hold the key to understanding disease, improving quality, and lowering healthcare costs. El...
IMAT-ITCR Collaboration: Engineering model-based systems to monitor and steer subclonal dynamics
PROJECT SUMMARY Ongoing cancer genomic studies have documented numerous mutations across all tumor types. Most cancer mutations have not been functionally characterized, as conduct...
Neural mechanisms of sensory over-responsivity in children with and without ASD
PROJECT ABSTRACT Sensory over-responsivity (SOR), or strong negative reactions to and avoidance of innocuous sensory stimuli, affects about one in five school-age children and abou...
Vascular sympathetic neurons in brown adipose tissue and systemic metabolism
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Cold exposure increases thermogenesis in brown a...
ZnT8-specific bioanalytical tools for probing autoimmune destruction of pancreatic beta-cells in type-1 diabetes
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Type-1 diabetes is a chronic autoimmune disease...
Resolving the mechanism of osteoclast multinucleation and signaling in bone remodeling
PROJECT SUMMARY: Essential, life-long bone remodeling is coordinated by osteoclasts (OCs) that resorb old bone and osteoblasts that deposit new bone. Elevated OC formation/function...
Exploring the Collaborative Cross resource to identify different phenotypes of Lyme neuroborreliosis and disease-contributing genetic factors
PROJECT SUMMARY Lyme disease (LD), the most prevalent tick-borne illness in the US (~300,000-475,000 annual cases), is caused by spirochetes of Borreliella burgdorferi (Bb) sensu l...
RNA editing controls pulmonary endothelial pathophenotypes in pulmonary hypertension
ABSTRACT The primary objective of this proposal is to generate a scientific discovery program in pulmonary vascular disease to ensure a robust pathway for Dr. Woodcock to develop i...