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99,167 grants found
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Evaluating the associations of hearing loss with cognitive and brain health outcomes in midlife
Project Summary Emerging evidence suggests hearing loss may be a modifiable risk factor for Alzheimer's disease (AD) and related dementias (ADRD). Midlife (ages 45-65) could b...
Next-generation Lasers for Enabling Ultrafast Functional Pulmonary MRI
PROJECT SUMMARY (30-line limit) Deadly lung diseases such as chronic obstructive pulmonary disease, asthma, lung injury, constrictive bronchiolitis, and pulmonary fibrosis affect &...
Improving Incontinence Support for Family Caregivers and Persons Living with Dementia
PROJECT SUMMARY There is a fundamental gap in our understanding of how best to care for persons living with dementia (PLWD) and urinary incontinence (UI), many of whom are being ca...
Elimination of slice alignment errors in 2-dimensional structural MRI
Project Summary: The goal of the proposed project is to develop and validate a novel motion correction technique for 2D T2-weighted structural MRI of the brain. Head motion continu...
Predicting fetal growth early in pregnancy with non-invasive MRI: Validation in a preclinical model
Project Summary Nearly 50% of all pregnancies complicated by fetal growth restriction (FGR) go undetected until after birth, despite improvements in obstetric imaging and managemen...
Quantitative Hydrophobicity Sensor to Probe the Dynamics of Biomolecular Condensates
PROJECT SUMMARY Many important cellular processes are regulated through the formation and dissolution of the biomolecular condensates via liquid-liquid phase separation (LLPS). LLP...
Fairness in Practice: Defining and Implementing Diversity & Representation in AI datasets for Healthcare
There is widespread agreement that fairness—ensuring equitable performance across similarly situated individuals and across groups—is a fundamental principle for ethical developmen...
Mayo Clinic Consortium for Gut Brain Communication in Parkinson's Disease
PROJECT SUMMARY Gastrointestinal (GI) symptoms, especially constipation, affect >50% of persons with PD (PwPD). However, these concepts are exclusively based on tertiary care st...
Small molecules targeting obesity-linked diabetes
Project Summary Up to 95% of diabetic population suffer from type 2 diabetes (T2D) with its prevalence rising rapidly. A gradual decrease in β-cell function closely associated with...
Neuroregeneration after stroke using Vascular Guidance
Project summary This study addresses the challenge of improving neural progenitor (NP) survival and migration in the context ofneurodegenerative diseases and brain injuries. It inv...
Rural-urban and within-rural disparities in Alzheimer's disease and Alzheimer’s disease-related dementias
PROJECT ABSTRACT This application proposes to examine where and for whom rural residence is associated with Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD)...
Biobehavioral Basis and Outcomes of Cognitive Dysfunction in Childhood-Systemic Lupus Erythematosus
ABSTRACT Cognitive dysfunction (CD) is a common neuropsychiatric manifestation of childhood-onset systemic lupus erythematosus (cSLE) that remains poorly diagnosed and undertreated...
Validating non-linguistic laboratory biomarkers of depression in persons with aphasia
Aphasia is a multi-modality disturbance of language that is more common than disorders such as Parkinson’s disease and has a greater negative impact on quality of life than Alzheim...
A Consortium for Gut-Brain Communication in Parkinson's Disease
Project Summary/Abstract We plan to initiate participation in the NIH U01 Consortium for Gut-Brain Communication in Parkinson’s Disease (PD) (GBPDC) including contribution of PD pa...
Longitudinal cohort of mushroom intake and cognitive function in the elderly
Project Summary/Abstract: The overall goal of this project is to determine the association of mushroom intake with cognitive function in a middle-aged and elderly cohort conducted...
Trunk control after human spinal cord injury
Abstract Walking recovery is a top rehabilitation goal for many individuals with incomplete spinal cord injury (ISCI). Accordingly, there are extensive resources invested into unde...
Exploring Historical Trauma, Racial Discrimination, PTSD, and Substance Use Among Black Young Adults
Project Summary Overdose deaths are exponentially rising for Black individuals compared to White, where over 50% of overdose fatalities are associated with polysubstance use. Polys...
Desmoplastic small round cell tumor: harnessing new insights and new models
The desmoplastic small round cell tumor (DSRCT) remains one of the most lethal adolescent/young adult (AYA) sarcomas. The EWSR1-WT1 gene fusion is the primary and defining genetic...
Novel subsampling and analysis of big data using examples from IRIS ® Registry
Abstract Observational studies based on big data from electronic medical records (EMRs) have been conducted recently in many areas of medical research [1, 2]. These results provide...
Alcohol tolerance encoding in sleep and memory circuits
Project Summary / Abstract A single acute ethanol exposure causes lasting changes in behavior and brain function. Acute changes may form a basis for progressive changes with subseq...