Browse All Grants
99,167 grants found
Showing 201 – 220 of 99,167 grants
Administrative Core
PROJECT SUMMARY/ABSTRACT The Administrative Core will provide a strong infrastructure as well as administrative and logistical support to ensure timely implementation of all Projec...
Community Engagement Core: Community Engagement will include Dialogue, Advocacy, and Research (CEDAR)
PROJECT SUMMARY/ABSTRACT The Fred Hutch/University of Washington/Seattle Children’s Cancer Consortium (the Consortium) catchment area includes all of Washington State (WA) and incl...
Research Project 1: Navigation and Artificial Intelligence Technology for Indigenous Virtual Education on smoking cessation (NAITIVE)
PROJECT SUMMARY/ABSTRACT American Indian/Alaska Native (AIAN) people have the highest rates of commercial cigarette smoking of any racial/ethnic group in the US. Compared to other...
ELECTROMECHANICAL COUPLING AND DISEASE MECHANISMS OF MYOCARDIAL CNBD FAMILY CHANNELS
PROJECT SUMMARY/ABSTRACT The CNBD family of channels, encompassing hyperpolarization-activated cyclic nucleotide-gated (HCN) and depolarization-activated KCNH members, plays a pivo...
Preservation of muscle function through Schwann cell regulation of motor unit expansion
ABSTRACT. Preservation of muscle function through Schwann cell regulation of motor unit expansion The loss of skeletal muscle mass and function with aging, known as sarcopenia, is...
Targeting Schwann cell dysfunction and repair signaling in chemotherapy induced painful peripheral neuropathy
PROJECT SUMMARY/ABSTRACT Chemotherapy-induced painful peripheral neuropathy (CIPPN) significantly reduces quality of life. Patients often require tapering or cessation of chemother...
Primary Prevention of Intimate Partner Violence
PROJECT SUMMARY Intimate partner violence (IPV) is experienced by one-fourth of women in India and associated with poor mental, physical, sexual and reproductive health, leading ma...
Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome
PROJECT SUMMARY Mortality remains high (20%) for the 8,000 US children each year that develop pediatric acute respiratory distress syndrome (ARDS). No pharmacologic therapies have...
A sex-biased obesity gene on the X chromosome
The leading cause of death in women in the United States is cardiovascular disease (CVD). Progress in reducing CVD in women has lagged behind progress in men. Obesity is a prevalen...
Validation of a Translational Model of Chronic Discogenic Low Back Pain
PROJECT SUMMARY Chronic low back pain associated with disc degeneration is a leading cause of chronic pain and has a substantial economic impact in the United States. Treatments fo...
Down Syndrome Memantine Follow-up Study: EEG Data Analysis and Data Sharing with the Research Community
ABSTRACT Down syndrome (DS) is the most common genetically defined cause of intellectual disability and a major cause of early-onset Alzheimer’s disease (AD)-type dementia. Recentl...
Multi-Center Validation and Biologic Assessment of a Novel Pre-Transplant Biomarker Panel to Predict Liver Transplant Recipient Mortality
PROJECT SUMMARY Due to organ shortage, livers are transplanted in order of recipient medical urgency; however, ethical principles dictate avoidance of futile transplantation. The m...
Grit against cognitive decline in aging and preclinical Alzheimer Disease
In most older adults, memory and other cognitive abilities decline with advancing age. This decline is not inevitable, however. Recent studies from our laboratory and others indica...
Alginate Hydrogels with Tethered IGF-1 Mimicking Peptides to enhance the Therapeutic Potency of Mesenchymal Stem Cells for Intervertebral Disc Repair
Degeneration of the intervertebral disc (IVD) is associated with changes to tissue composition and structure that include a loss of IVD height, decreased water content and decrease...
Onco-immunologic factors contributing to OPSCC among people living with HIV
Oropharyngeal cancer (OPC) is a type of head and neck cancer and ~70% cases of OPC are associated with high-risk (hr) human papillomaviruses (HPV) infection. OPC cancers are increa...
Uncovering the role of extracellular condensates as triggers of neuroinflammation
PROJECT SUMMARY Historically largely focused on the demise of neurons, a wealth of literature in the neurodegeneration field has provided strong evidence for a critical role of neu...
Informing Lifestyle Recommendations for Kidney Cancer Survival: Investigating the Role of Dietary Patterns and Physical (In)activity
PROJECT SUMMARY Renal cell carcinoma (RCC) accounts for 4.1% of new cancer cases in the United States (US) – 1 out of every 25 diagnoses – and the number of individuals living with...
Parental alcohol and cannabis before and during pregnancy: a pilot study
SUMMARY Alcohol is the most commonly used licit substance in pregnancy, and cannabis is the most commonly used illicit substance in pregnancy. Approximately half of pregnant people...
Proof of concept: diclofenac as a KMO inhibitor in AUD
Summary The development of efficacious medications for AUD remains a high research priority with current emphases on identifying novel molecular targets and efficiently screening n...
Developing and testing a measure of sociocultural norms related to interpregnancy intervals in African immigrants in the US.
PROJECT SUMMARY Despite the existence of guidelines from the World Health Organization and the American College of Obstetricians and Gynecologists recommending an optimal interpreg...