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99,167 grants found
Showing 201 – 220 of 99,167 grants
Defining the effect of Alzheimer pathologies on the aged brain in 3 dimensions
This proposal, to create the 3D Aging & Alzheimer Brain Program, addresses several critical gaps in ongoing efforts to bridge the divide between known risk factors for Alzheimer’s...
Biology and pathobiology of apoE in aging and Alzheimer's disease
PROJECT SUMMARY (APOE U19: OVERALL) The overarching goal of this U19 project is to comprehensively understand the biology and pathobiology of apolipoprotein E (apoE) in aging and...
Characterization, optimization, and development of dual mGlu2/3 positive allosteric modulators for opioid use disorder
PROJECT SUMMARY Opioid Use Disorder (OUD) is a significant problem worldwide and a surge in methamphetamine (MA) use has emerged in chronic opioid users. Given recent increases i...
Impact of maternal substance use on offspring neurobehavioral development
Substance use in pregnancy is a significant public health problem and is associated with adverse offspring neurodevelopmental and behavioral outcomes, including cognitive dysfuncti...
Broad neutralization of pandemic threat coronaviruses
ABSTRACT-OVERALL The recurrent emergence of coronaviruses from animal reservoirs, and the resulting COVID19 pandemic, necessitates the development of interventions that can targ...
Postnatal and Prenatal Therapeutic Base Editing for Metabolic Diseases
PROJECT SUMMARY The potential for the development of novel therapeutic modalities has energized the genome editing field since it first emerged in the 1990s and especially since...
The CRISPR Vision Program: Nonviral Genome Editing Platforms to Treat Inherited Retinal Channelopathies
PROJECT SUMMARY/ABSTRACT – OVERALL The genome editing community is celebrating the ten-year anniversary of landmark CRISPR papers in 2022. What is notable to many in the field is...
The Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)
Dementia due to Alzheimer’s disease and related dementias (ADRD) disproportionately impacts racial/ethnic minorities and the socioeconomically disadvantaged. Development of effect...
The Rhythm Evaluation for Anticoagulation with Continuous Monitoring of Atrial Fibrillation Trial (REACT-AF)
Project Summary / Abstract Purpose: The Rhythm Evaluation for AntiCoagulaTion with Continuous Monitoring of Atrial Fibrillation (REACT AF) clinical trial will compare the efficac...
HOPE - HIV Obstruction by Programmed Epigenetics
PROJECT SUMMARY/ABSTACT After 40 years, a cure for people living with HIV (PLWH) remains both elusive and one of NIAID/NIH’s highest priorities. Rebound-competent latent reservoi...
GH21-003, Advancing Public Health Research in Kenya
SUMMARY (ADMINISTRATIVE CORE) Our Consortium consisting of Washington State University (WSU), the Liverpool School of Tropical Medicine (LSTM), and the Kenya Medical Research Insti...
Defining the effect of Alzheimer pathologies on the aged brain in 3 dimensions
This proposal, to create the 3D Aging & Alzheimer Brain Program, addresses several critical gaps in ongoing efforts to bridge the divide between known risk factors for Alzheimer’s...
VULNERABILITY AND RESILIENCY IN THE AGING ADULT BRAIN CONNECTOME (AABC)
ABSTRACT FOR OVERVIEW The Aging Adult Brain Connectome (AABC) leverages the existing infrastructure developed by the Human Connectome Project for Aging (HCP-A) by obtaining long...
The Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)
Dementia due to Alzheimer’s disease and related dementias (ADRD) disproportionately impacts racial/ethnic minorities and the socioeconomically disadvantaged. Development of effect...
HEALing Communities Study Data Coordinating Center
PROJECT SUMMARY/ABSTRACT A seeming unrelenting opioid crisis is devastating the United States, with rural states and communities being hit especially hard. Actionable guidance is...
Generation, Characterization, and Validation of Marmoset Models of Alzheimer's Disease
PROJECT SUMMARY OVERALL Alzheimer’s disease (AD) is a devastating neurodegenerative disorder affecting nearly 6 million Americans and is expected to increase over the next sever...
Add Health Parent Study: A Biosocial Resource for the Study of Multigenerational Racial/Ethnic Disparities in Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD)
Abstract Significant knowledge gaps exist regarding intergenerational dimensions of cognitive aging and risk for Alz- heimer’s Disease and Alzheimer’s Disease Related Dementias (...
The Michigan Infectious Disease Genomics (MIDGE) Center
Project Summary – Overall The advent of genomic sequencing technologies has revolutionized our understanding of disease transmission, pathogen evolution, drug resistance, and vir...
Tracking the emergence of internal models
Abstract Central to human and animal cognition is the idea of internal models: an internal repository of knowledge about the structure of the world and its affordances that enabl...
Alzheimer's Disease and Related Dementias (ADRD) prevalence in American Samoa
ABSTRACT Alzheimer’s disease and related dementias (ADRD) affects over 5.7 million Americans and over 35 million people worldwide. Indigenous populations including American India...