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99,167 grants found
Showing 2,161 – 2,180 of 99,167 grants
Molecular Mechanisms Underlying Luminal- Neuroendocrine Transdifferentiation
Summary The objective of this proposal is to determine the molecular mechanisms underlying luminal-to-neuroendocrine transdifferentiation (NET) of prostate cancer (PCa). NET underl...
A Novel Blood Substitution Approach Treats Acute Ischemia in the Aged Brain
Project Summary/Abstract Aging is associated with a striking increase in the incidence of stroke, which is a major cause of disability among those aged 65-years and older. Effectiv...
Engineering an extracellular vesicle-based targeted regenerative nanotherapeutic for multiple sclerosis
ABSTRACT Multiple sclerosis (MS) is an autoimmune disease that gives rise to chronic neurological deficits. It is caused by an immunological attack on the myelin sheath leading to...
Pharmacokinetics (PK) and Pharmacodynamics (PD) Characterization of mTOR Inhibitors in Older Adults
Abstract Aging is the time-dependent functional decline responsible for increased susceptibility to chronic disease, frailty, and disability. Aging is a substantial public health c...
Impact of Wildfire Smoke on Lung Injury
ABSTRACT The US Environmental Protection Agency recognizes wildfire smoke as a significant source of particulate matter under 2.5 microns diameter (PM2.5) emissions, which are expe...
Programmable Phage Display Peptidomes to Characterize Uveitis
PROJECT SUMMARY/ABSTRACT Uveitis is a heterogenous group of ocular inflammatory diseases that results in significant ocular morbidity and can cause long-term blindness if not diagn...
Extensively drug resistant Pseudomonas aeruginosa keratitis outbreak strain: virulence mechanisms and mitigation
Project Summary / Abstract The recent outbreak of keratitis caused by an extensively drug-resistant (XDR) strain of Pseudomonas aeruginosa with blaVIM-80 and blaGES-9 associated wi...
3D Spatial Multi-Omics Profiling of Ovarian Cancer
Research Summary: High-grade serous ovarian cancer (HGSOC) is the most common histologic subtype of ovarian cancer. Despite ongoing efforts to develop effective surgical and treatm...
Mechanisms and discovery of small-molecule effectors targeting cardiac ion pumps
PROJECT SUMMARY/ABSTRACT The overarching goal of our proposed research is to determine the mechanisms underlying small-molecule activation of the cardiac calcium pump (sarcoplasmic...
Center for Human Lymphoma Spatiotemporal Atlas (HuLymSTA)
SUMMARY Non-Hodgkinlymphomas (NHL) represent about 90% of all lymphomas diagnosed each year and is classified based on cell type - B cell, T cell and natural killer (NK) cell types...
Center for Gastric Pre-Cancer Atlas of Multidimensional Evolution in 3D (GAME3D)
PROJECT SUMMARY This application aims to address the urgent need for precision in intercepting hereditary diffuse gastric cancer (HDGC) associated with pathogenic germline CDH1 mut...
A Multimodal 3D Atlas of Colorectal Cancer Across Ages of Onset
PROJECT SUMMARY We propose the construction of a three-dimensional (3D) multimodal molecular atlas of colorectal cancer (CRC) across different ages of onset of the disease. We aim...
Human Prostate Tumor Atlas Center
Project Summary Earlier gains in reducing prostate cancer (PCa) mortality, partially due to advances in screening and the use of androgen deprivation therapy to treat metastatic PC...
Pre-cancer atlas of skin cancer
The overarching goal of our proposal is to develop a pre-cancer atlas of skin cancer. Skin is an ideal model to study the early phases of tumorigenesis because it is easily accessi...
AI-enabled characterization of fibrocalcific aortic valve disease and inflammation from CT Angiography: Patient-specific outcome prediction
PROJECT SUMMARY Aortic stenosis (AS)—narrowing of the aortic valve—is the most common heart valve disease. Degeneration of leaflets in AS leads to valvular obstruction, thickening...
An atlas of pancreatic tumorigenesis in the context of altered DNA repair occurring in high-risk individuals
PROJECT SUMMARY/ABSTRACT Pancreatic Ductal Adenocarcinoma (PDAC) is on track to become the second leading cause of cancer related deaths in the United States. This dismal prognosis...
Understanding the role of tumor microenvironment in low grade glioma progression to malignancy
ABSTRACT Our PCA research center brings together the UCLA Neurosurgery team with the Caltech spatial single cell team to construct a comparative spatial atlas of low-grade gliomas....
Transcranial Electrical Stimulation in Stroke EaRly After onset Clinical Trial-2 (TESSERACT 2)
Acute ischemic stroke (AIS) is a leading cause of death and disability for which treatments are limited to reperfusion therapies, including intravenous thrombolytic (lytic) and end...
The Aging Pancreas as a Pro-tumorigenic Niche
PROJECT SUMMARY Age is a major risk factor for pancreatic ductal adenocarcinoma (PDAC), with the incidence of PDAC rising sharply with increasing age. Most PDAC cases occur in indi...
Leveraging Community-Engaged Research to Co-Create Youth Vaping Prevention with Urban Indigenous Communities of the Southwest
Leveraging Community-Engaged Research to Co-Create Youth Vaping Prevention with Urban Indigenous Communities of the Southwest ABSTRACT The prevalence and early initiation of nicoti...