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99,167 grants found
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IRS2 and mitotic regulation in breast cancer
Project Summary The overall goal of this proposal is to determine the mechanism by which Insulin Receptor Substrate 2 (IRS2) regulates the spindle assembly checkpoint (SAC) and to...
Interrogating the protective effect of African APOE alleles on Alzheimer's disease risk through pleiotropy
Project Summary/Abstract Alzheimer’s disease (AD) is a highly heritable trait, where much of the phenotypic variation is explained by genetic variation. A significant proportion of...
Returning AD biomarker Results to Community Dwelling Older Adults: Testing Modalities and Impact
Project Summary This study will develop a process to return Alzheimer Disease (AD) biomarker research results and will evaluate whether the results can be sent directly to particip...
Cellular Senescence in Trisomy 21 lung disease
SUMMARY Trisomy 21 (T21) occurs in ~1 in 700 live births resulting in Down Syndrome (DS), where pulmonary complications are the main cause of hospitalizations in children and adult...
Hyperpolarized 13C MRI of Cardiac Metabolic Remodeling in Heart Disease
Project Summary Abnormalities in cardiac energy metabolism and mitochondrial dysfunction have been implicated in numerous heart diseases such as hypertrophic cardiomyopathy (HCM),...
Influence of microglial cell depletion and repopulation on aducanumab induced ARIA and vascular lesions in APOE4 carriers with AD
After many failed clinical trials, the FDA recently approved new breakthrough antibody therapy for use in early AD. But thesetherapies have been revealed to increase the frequency...
Mechanisms Driving the Rapid Evolution of Cancer Genomes
PROJECT SUMMARY/ABSTRACT The goal of this proposal is to identify the mechanism of catastrophic mutational processes that drive very rapid evolution of cancer genomes. One of these...
Molecular basis of cell-cycle plasticity and robustness
Project Summary The mammalian cell cycle is commonly conceived as a well-understood, hardwired, invariant pathway. Emerging work, however, indicates that the cell cycle is much mor...
Development of a real-time interactive PET/US imaging technology to enhance theranostics applications in precision medicine
Project Summary / Abstract This project will develop a novel molecular imaging technology that combines positron emission tomography (PET) and ultrasound (US) imaging to enable int...
Investigating an African American-specific APOE genetic variant using hiPSC
PROJECT SUMMARY ABSTRACT African Americans are at a significantly elevated risk of Alzheimer’s disease (AD) compared to the non-Hispanic white population. Yet, the underlying mecha...
Role of EphA1/A2 domain-domain and -membrane interactions for receptor specificity and Blood Brain Barrier dysfunction
Ligand activation of Eph receptors plays a decisive role in cell migration during blood vessel formation and neuronal axon guidance. Eph receptors can also signal independently of...
A multimodal examination of functional network health and its relationship with tau deposition
Abstract Alzheimer’s disease (AD) affects millions of people worldwide, and its prevalence is expected to increase dramatically in the coming years. Although some people are resili...
Bifunctional Inhibitors of STING as Chemical Probes for Diabetic Retinopathy
PROJECT SUMMARY More than 40% of patients with diabetic retinopathy (DR) are refractory to direct intraocular injection of anti- VEGF antibodies, the standard of care. The inabilit...
Radiation and dendritic cell combination to improve immunotherapy response in intrahepatic cholangiocarcinoma
Summary Intrahepatic cholangiocarcinoma (iCCA), the second most common primary liver cancer after hepatocellular carcinoma (HCC), is an aggressive malignancy with dismal overall pr...
Explicit, Vicarious and Internalized Racial Discrimination on Daily Associations and Long-Term Health Trajectories among Filipino, Korean, and Indian Americans
ABSTRACT The alarming 339% increase in the incidence of explicit racial discrimination (e.g., threats, unfair treatment due to one’s race) experienced by Asian Americans since the...
Stromal targeting to improve the efficacy of systemically administered drugs for pancreatic ductal adenocarcinomas
Project Summary Only about 20% of pancreatic ductal adenocarcinoma (PDAC) patients are expected to survive one year from diagnosis, with the overall 5-year survival rate reported a...
Autoimmune Basis of Acquired Lipodystrophies
Obesity remains a major health problem in US and causes metabolic complications such as diabetes, dyslipidemia and insulin resistance. Similar complications also occur in patients...
Defining the onset and regulation of myogenic upper urinary tract physiology
AbstractImpaired urinary outflow that causes damage to the urinary tract and kidney is a major cause of kidney disease, which affects 15% of the population and costs $100B annually...
Decreasing Cardiometabolic Risk in Survivors of Childhood Cancer: Survivors engaged in Time-Restricted EatiNG after THerapy (STRENGTH)
PROJECT SUMMARY Over 500,000 survivors of childhood cancer are living in the United States today. Cardiovascular disease is the leading cause of noncancer late mortality in this co...
Compartmentalized cAMP signaling in reactive astrocytes
PROJECT SUMMARY Glaucoma is the leading cause of irreversible blindness and along with other optic neuropathies is characterized by the loss of retinal ganglion cells (RGCs). Incre...