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99,167 grants found
Showing 2,121 – 2,140 of 99,167 grants
Informatics strategies to improve immune-related adverse event detection in cancer patients
PROJECT SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have drastically improved cancer survival over the past decade, but this survival comes at the cost of a new class of i...
Hyperexcitability in Alzheimer's Disease
ABSTRACT In the past funding period we focused on hyperexcitability, because several studies in rodents and humans suggested it played an important role in AD pathophysiology. We s...
Local protein synthesis in tau pathology neurodegeneration
PROJECT SUMMARY/ABSTRACT Alzheimer's disease is a progressive, age-related, degenerative brain disease. The most notable symptom is a significant cognitive impairment accompan...
Stellate Ganglia Nrf2 Signaling and Enhanced Cardiac Sympathetic Tone in Chronic Heart Failure
Abstract Excessive oxidative stress has been shown to be a potent pathophysiological mediator in multiple disease states. Cardiac and peripheral sympathetic nerve activity is incre...
Telehealth Use in Nursing Homes and the Quality of Care for Long-Stay Residents with Alzheimer's Disease and Related Dementias
PROJECT SUMMARY/ABSTRACT Expansion of Medicare coverage of telehealth services during the COVID-19 public health emergency (PHE) removed many of the barriers to telehealth provisio...
Redirected CaMKII for restoring deficits in Alzheimer's disease models
PROJECT SUMMARY/ABSTRACT Alzheimer's disease is a progressive, degenerative brain disease. The major symptoms are impairments in memory and cognitive functions. These changes...
Sex and gender influences on inflammation and pain in sickle cell disease
PROJECT ABSTRACT Females with sickle cell disease (SCD) in the United States face a health disparity triple threat as a result of their chronic disease, race, and sex. In addition...
Participatory System Dynamics to Enhance PrEP Access for Black and Latinx Sexual Minority Men in Bronx, NY
ABSTRACT Black and Latinx sexual minority men (BLSMM) in the Bronx, NY and in the U.S. overall are among the populations most impacted by HIV in both Bronx, NY and in the U.S. BLSM...
Clarifying phenotypes of suicide risk in preteen youth: An intensive longitudinal assessment study
PROJECT ABSTRACT Suicide risk is increasing in preteens, 8-12-years old. Although research is limited, it is estimated that 15% of preteens in community samples and 43% in clinical...
Wiring and rewiring of the chromatin landscape during retinogenesis
SUMMARY: The proper execution of transcriptional programs in retinal progenitor cells is extremely critical for retinal formation as dysregulation of this process leads to severely...
Community-Engaged Modeling and Implementation Science to Develop Re-Linkage Interventions for Black Sexual Minority Men with HIV
ABSTRACT Background: Black sexual minority men (SMM) are disproportionately impacted by HIV and multiple social determinants of health (SDOH), such as housing instability, unemploy...
In situ cryo-EM of protein condensates in the early secretory pathway of neurons
Neurons are highly polarized cells that exhibit distinct moieties that serve to receive (dendrites) and transmit (axons) electrochemical signals. In a variety of neurodegenerative...
Preparing for a clinical trial to implement a fully implanted neuroprosthesis to restore walking after partial paralysis
The long-term objective of this project is to improve the walking speed and stability of Veterans disabled by incomplete SCI (iSCI), stroke, or multiple sclerosis sufficiently to s...
A Multilevel Investigation of Migration and Dementia Risk Among Mexican Americans
ABSTRACT The US-Mexico migration corridor is one of the busiest in the modern era. In the United States, over 15 million adults ages 50+ are foreign-born, most of Mexican origin. A...
Optimizing CNS DHA delivery in elderly adults at risk for dementia
ABSTRACT There exists an urgent need to develop and evaluate early interventions to mitigate neurodegenerative processes in aging adults at increased risk for Alzheimer’s disease (...
Using redox balance to guide surgical and therapeutic decisions for cartilage disease
PROJECT SUMMARY/ABSTRACT The goal of this research project is to develop optical redox imaging (ORI)-based medical instruments to guide surgical and therapeutic approaches in early...
Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes
PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is a major cause of death in individuals with type 1 diabetes (T1DM), but the underlying mechanisms are not well understood. D...
Intersection of cytoskeletal regulation with tumor cell metabolism
SUMMARY Pancreatic cancer (PDAC) is particularly lethal, due in part to a resistance to therapies and a high incidence of metastasis. The overall goal of our research program is to...
Defining pro-metastatic drivers in the pancreatic cancer tumor microenvironment
PROJECT ABSTRACT Pancreatic adenocarcinoma (PDAC) is an almost uniformly fatal disease most often diagnosed after the development of metastases. The tumor suppressor gene, TP53, is...
Epigenetic Aging Cognitive Function and Exercise in Older Adults
Abstract In the United States, 1 in 9 individuals 65 and older and one third of individuals 85 and older have Alzheimer’s dementia (AD). By age 70, age-related cognitive decline is...