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99,167 grants found
Showing 2,081 – 2,100 of 99,167 grants
Randomized trial of Veteran peer navigators to promote Shared Decision Making for PSA screening
Background: Prostate cancer is the most common non-cutaneous malignancy among men in the United States, accounting for one third of VA’s new cancer diagnoses. The United States Pre...
Dynamics of Ghanaian immigrants' health in the US: Critical life-stage experiences, social networks, acculturation and selection (GMHeS)
PROJECT SUMMARY: Sub-Saharan Africa (SSA) has the world’s fastest-growing population and SSA-US migration is growing rapidly, contributing to greater demographic heterogeneity and...
Translational Studies toward Cell Therapy for Treatment of Primary Open Angle Glaucoma
Decreased visual ability in veterans quickly leads to functional impairment and with it, reduced quality of life. In the year 2016 eye care was the third busiest clinical service i...
Biomimetic intervention strategies for endogenous in utero repair of Spina Bifida
ABSTRACT Neural tube defects (NTDs), including spina bifida (SB), have a devastating impact on the health and development of infants and children, with economic, social, and physic...
Adaptation and feasibility testing of an AI-enabled web app based on acceptance and commitment therapy for family caregivers of people with dementia
Project Summary/ Abstract The greatest unmet need in family caregivers of persons living with dementia (PLWD) is support for these caregivers’ mental health. Family caregivers of P...
Impact of physician, hospital, and skilled-nursing facility factors related to geriatric care on days spent at home among persons with AD/ADRD
Abstract Although many persons living with Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) prefer to remain at home as long as possible, they spen...
The Role of the Exposome and Allostatic Load in Risk and Resilience to Youth Suicide Attempts
ABSTRACT Suicide is the second leading cause of death in US youth. Suicidal behavior is complex and is influenced by a combination of multi-level distal and proximal environmental...
Immigrant Integration and Health: Multidimensional and Cross-National Analyses Over the Life Course
Project Summary Title: Immigrant Integration and Health: Multidimensional and Cross-National Analyses Over the Life Course. Older immigrants of color have high levels of cognitive...
Determining themechanism of maternal IL-10 restriction of fetal emergency myelopoiesis to improve neonataloutcomes
PROJECT SUMMARY/ABSTRACT Maternal infections during pregnancy lead to adverse outcomes for the offspring, including short-term outcomes such as intrauterine fetal demise, preterm d...
Complementary pathways of necroptosis in recipient and donor lung tissue that drive primary lung allograft dysfunction
In this proposal, we aim to address a critical challenge in lung transplantation: primary graft dysfunction (PGD), a severe complication impacting over half of all lung transplant...
Role of Rasa1 in embryonic development
PROJECT SUMMARY Vascular and lymphatic anomalies comprise a spectrum of defects that originate in embryonic blood or lymphatic vessels and are present at birth. These defects can b...
Social Connectedness in People with Amyotrophic Lateral Sclerosis: The Impact of Dysarthria, Immobility, and Psychosocial Factors
PROJECT SUMMARY People living with amyotrophic lateral sclerosis (ALS) are at high risk for social disconnection (such as isolation and loneliness) as their impairments progressive...
Investigating DNA polymerase O in replication stress and cancer therapy
Principal Investigator: Wu, Xiaohua Project Summary Replication stress often occurs when DNA replication is disrupted, leading to DNA double-strand break (DSB) formation. Replicati...
Evaluating novel transcription factors in regulating astrocyte identity, reactivity, and their roles in neurodegenerative disease pathogenesis
Abstract This proposal leverages a new interdisciplinary collaboration between Drs. Guoyan Zhao and Erik Musiek to define the transcriptional control of astrocyte identities, react...
Targeting Surfactant Protein A to Prevent Retinopathy of Prematurity
PROJECT SUMMARY Retinopathy of prematurity (ROP) is a potentially blinding vaso-proliferative disease frequently seen in prematurely born infants with lifelong consequences for bot...
Neurological effects of aerosolized red tide neurotoxins
The observed increased occurrences of harmful algal blooms (HABs) are largely a consequence of ocean warming due to climate change, eutrophication, and nutrient pollution, which ra...
Latin America Genomics of Breast Cancer Risk Study (LAGENO-BCR)
SUMMARY/ABSTRACT Breast cancer is a leading cause of death in the U.S. and a major public health burden as one woman out of eight will receive a diagnosis in her lifetime. Advances...
CARMIL1 and Endothelial Barrier Function Regulation
ABSTRACT The acute respiratory distress syndrome (ARDS) is characterized by pulmonary vascular leak and flooding of the normally air-filled alveolar space with protein rich edema f...
Three-dimensional mapping and modeling of combinatorial interactions underlying biomolecular condensates in olfactory neurons
Summary: Gene regulation is controlled by the dynamic localization of numerous regulatory factors to precise nuclear targets. Classic diffusion and affinity models alone cannot exp...
Determining the relationships between provider bias, experiences of ableism, and health outcomes for people with mobility disabilities
Project Title: Determining the relationships between provider bias, experiences of ableism, and health outcomes for people with mobility disabilities Project Abstract Ableism, the...