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99,167 grants found
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Hyperactivity of the thalamo-hippocampal-prefrontal circuit as a mechanism for anxiety in Alzheimer disease - Resubmission - 1
PROJECT SUMMARY/ABSTRACT Anxiety is a highly prevalent symptom in the early stages of Alzheimer disease (AD), with correlation to AD biomarkers and association with faster decline....
Video-oculography: A novel approach towards clinical markers of vestibular function and recovery
PROJECT SUMMARY Loss of vestibular function causes visuospatial misperception, imbalance, and decreased visual acuity during head motion, leading to severe impairment of daily acti...
The role of stress physiology and reproductive hormones in the relationship between cannabis use and sleep in women of childbearing age
ABSTRACT This proposal aims to characterize the unique effect of recreational cannabis use on sleep in women. Sleep was once believed to be a quiescent state, where self-reported m...
CT-based Characterization of Lung Volume-determined Airway and Chest Wall Deformation Interdependences in COPD
AbstractOverview: This research study will leverage established datasets from nationwide longitudinal lung studies to characterize multi-volume mechanical changes affecting airway...
Development of an innovative Non-Invasive MR Imaging Technique for assessing Membrane Lipids and Their Properties in Alzheimer's Disease
PROJECT SUMMARY Phospholipids, the fundamental components of cell membranes, play a crucial role in brain function. Research indicates that changes in membrane lipid composition an...
Improving the analysis and use of contaminated immunoassays: from methods development to implementation
PROJECT SUMMARY Immunoassays – tests that estimate the concentration of analytes in a sample using antibody-antigen binding reactions – are widely used for clinical diagnostics, bi...
Major Histocompatibility Complex I regulation of microglial function in aging and Alzheimer's Disease
Abstract: Systemic and CNS sterile inflammation (inflammaging) are proposed drivers of brain aging and neurodegenerative diseases (e.g., Alzheimer’s disease, AD). Microglia, the re...
Rehabbing with Peloton: Commercially Available Fitness mHealth for Cardiac Rehabilitation among Individuals Recovering from Transcatheter Aortic Valve Replacement
ABSTRACT The proposed project is a resubmission by two promising Early-Stage Investigators as multiple principal investigators (PAR-22-189). The overall goal of this multi-phase pr...
Caregivers Preparing for Their Own Health Care Emergency
Summary The overarching goal of the proposed work is to engage spousal caregivers of patients with dementia to plan for their own health emergency. Serious, unexpected health event...
Tools to facilitate preventive therapy for children and adolescents in primary care.
SUMMARY Children and adolescents exposed to tuberculosis (TB) in their homes (i.e. household contacts) are at high risk for developing active TB disease if they do not receive TB p...
Optimizing Dimensions of Reinforcement to Enhance Behavioral Interventions
Project Summary/Abstract Over 2 million people in the United States with intellectual and developmental disabilities (IDD) engage in some form of severe problem behavior (SPB; self...
Characterizing human exposure to microplastics during pregnancy
Global plastic pollution is a significant environmental and public health concern. Plastic production has increased since the 1950s, reaching approximately 368 million metric tons...
Timing and risk factors for developing chronic respiratory failure after pediatric sepsis
ABSTRACT Each year in the US, over 70,000 children are hospitalized with sepsis. Of the nearly 90% of children who survive sepsis, many face physical, emotional, and cognitive morb...
Mapping Corticoreticulospinal Motor Control Using Brainstem and Spinal Cord fMRI in Chronic Hemiparetic Stroke
PROJECT SUMMARY Approximately 60% of hemiparetic stroke-survivors experience significant chronic motor deficits in their paretic upper limb, typically caused by damage to the corti...
Enhancer RNAs and enhancer-centric gene regulatory networks in vascular dementia
Recent studies have reported widespread transcription of mammalian enhancers into noncoding RNAs in a stimulus-dependent manner. Growing evidence shows that these RNAs, known as en...
Disentangling the genetic mechanisms of endometriosis severity with single-cell multi-omics
ABSTRACT Around 10% of reproductive-age women have endometriosis, but the molecular drivers of this common chronic gynecologic condition are poorly understood. Endometriosis is a m...
The choice of vasopressor to prevent postoperative acute kidney injury after major non-cardiac surgery: a multicenter pragmatic cluster cross-over randomized trial (the VEGA-2 trial)
PRINCIPAL INVESTIGATOR (LAST, FIRST, MIDDLE): Legrand, Matthieu TITLE OF PROPOSED STUDY: The choice of vasopressors to prevent postoperative acute kidney injury after major non-car...
Development of a Novel Diagnostic Modality for Upper Airway Obstruction via Integrating Dynamic Computed Tomography with Computational Fluid Dynamics
Project Summary/Abstract In the current state, clinical airway management decisions for patients with upper airway obstruction (UAO) are made based on a combination of qualitative...
A domain-specific approach to falls efficacy and walking activity in individuals with chronic stroke
Summary Individuals with chronic stroke are characterized by low levels of walking activity, which negatively impacts post-stroke health and the risk for recurrent stroke. Although...
Regulated PTEN expression to overcome barriers to corticospinal tract regeneration after spinal cord injury
Project Summary: 30 lines of text (Currently 28): Spinal cord injuries (SCI) disrupt the communication pathways in the spinal cord, leading to paralysis, primarily affecting the co...