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99,167 grants found
Showing 2,041 – 2,060 of 99,167 grants
Prescribing Cascades among Nursing Home Residents with ADRD
PROJECT SUMMARY Polypharmacy, usually defined as the concurrent use of five or more medications, occurs in over 90% of nursing home (NH) residents with Alzheimer’s Disease and Rela...
Home-Based, Digital Intervention to Increase Physical Activity in Patients with the Fontan Circulation
SUMMARY/ABSTRACT Patients who undergo cardiac surgeries to establish the Fontan circulation (FC) suffer from lifelong complications and early mortality. Engaging in physical activi...
Mapping Brain Lipid Architecture in Aging, LBD and T Cell Therapy using novel Imaging Mass Spectrometry
PROJECT SUMMARY Dementia with Lewy bodies (LBD) and Parkinson's disease (PD) are characterized pathologically by the presence of Lewy bodies, composed of misfolded alpha synuc...
Molecular design for circuit engineering in the Drosophila brain
PROJECT SUMMARY Understanding how our brain produces complex feelings, decisions, and behaviors is a daunting task. Each of the ~130 trillion synapses in the human brain could pote...
Developing and pilot testing an eHealth decision support tool for young trans women to improve informed decision making about PrEP
Project Summary Transgender women (TW) have the highest rates of new HIV infections in the US yet are less likely to be aware of, use, or adhere to PrEP. This is especially worriso...
Advanced Imaging for Pulmonary Fibrosis
While it is well known that idiopathic pulmonary fibrosis (IPF) has a devastating disease course, approximately 30% of individuals with non-IPF interstitial lung disease (ILD) will...
Preclinical evaluation of physical and biological interventions to reduce post- traumatic joint contracture
PROJECT SUMMARY Post-traumatic joint contracture (PTJC) causes debilitating loss of motion following joint injury and is particularly impactful in the elbow. Clinical treatment is...
Genetic variants guiding pathogenicity of colitogenic T cells
SUMMARY ~2.4 million people in the United States have inflammatory bowel diseases (IBDs). While these severe and debilitating diseases have a genetic component, as determined from...
Advanced Personal Sampler to Assess Occupational Exposures to Bioaerosols
This grant application responds to PAR-18-812: Occupational Safety and Health Research (R01). Exposure to airborne biological agents is known to cause a wide range of negative heal...
Ex Vivo Nanoparticle Drug Delivery Targeted to Human Allograft Endothelium
7. Project Summary/Abstract Peri-transplantation inflammation of solid organ allografts exacerbates acute cell-mediated rejection and increases late graft loss, primarily caused by...
Developing new mouse models of andropause for ADRD research
PROJECT SUMMARY/ABSTRACT Aging and AD are associated with a decline in sex hormones. Approximately 40% of men over 45-years old suffer from low androgen levels. Endocrine aging in...
Eosinophils as Effectors of Antibacterial Immunity in the Lungs
Pneumonia results from uncontrolled lung inflammation and injury often triggered by viral/bacterial pathogen insults. Pneumococci, instigating agents of bacterial pneumonia, are in...
Optimizing PrEP uptake for African American women in the South by empowering women to make informed HIV prevention and sexual health choices
Project Summary Black women are disproportionately impacted by HIV accounting, for 54% of new infections while constituting only 13% of women in the US in 2019. These disparities a...
Demography of Immigrant Mortality in the United States: Leveraging Novel Census Linkages to Death Records, Earnings Trajectories, and Residential Mobility
PROJECT SUMMARY In this project, we study the mortality experience of the U.S. foreign-born population in unprecedented detail leveraging innovative individual-level data linkages...
NOX2 Small Molecule Inhibitors as a Therapeutic Strategy in the Treatment of Alzheimer’s Disease
Alzheimer’s Disease (AD) and related dementias are neurodegenerative disorders of paramount importance, in particular as medical advances continue to extend human lifespans and as...
Using AI on Routine Clinical and Imaging Data from Acute Stroke Encounter to Predict Post-Stroke Vascular Contributions to Cognitive Impairment (AI - RESPECT)
Project Summary Poststroke cognitive impairment (PSCI) was found to be common in various research studies. PSCI is ideally recognized through cognitive screening and test but they...
D-CARE End of Life Study
Several dementia care management models have been developed to comprehensively meet the needs of the growing number of Americans living with dementia and their caregivers. In 2018,...
Effects of embedded Acceptance and Commitment Training in DVM and RVT programs as students transition into the workforce
Project Summary/Abstract This is an R01 application to prospectively evaluate an asynchronously-delivered intervention (“Unburdened”) that targets reactivity to difficult client in...
Replication fork protection and innate immune response
ABSTRACT Protection of stalled replication forks is crucial for cells to respond to replication stress and maintain genome stability. Recent research has provided strong evidences...
Striatal Trans-Synaptic Signaling Mechanism in Parkinsonism
Summary: In the United States alone each year an estimated 60,000 individuals are diagnosed with Parkinson's disease (PD) with an economic cost of over fifty billion dollars e...