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99,167 grants found
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Quantification and Classification of Aqueous and Vitreous Inflammation in Uveitis Using Deep Learning Analysis of Ultrahigh-Resolution OCT
PROJECT SUMMARY Uveitis is a common cause of blindness in the United States. The specific cause of uveitis is often unknown, making it difficult to implement targeted testing and t...
Exploring TMEM106B in Neurodegeneration: Protein Interaction and Fibril-induced Neurotoxicity
PROJECT SUMMARY The increasing aging population presents a heightened risk of neurodegenerative diseases. Frontotemporal dementia (FTD) is one of these disorders and is the most co...
Improving treatment of lactation mastitis: leveraging claims data to fill evidence gaps
SUMMARY Lactation mastitis is an extremely painful and debilitating condition that affects 10-25% of breastfeeding people and can progress to breast abscess or septic fever. This s...
Advancing Diagnosis of Dementia in Primary Care Practice(ADDPCP)
PROJECT SUMMARY As the U.S. population ages, the number of people with Alzheimer’s disease and related neurodegenerative diseases (NDDs) that cause dementia will grow. Emerging dis...
Dopaminergic Mechanism for Familiarity and Memory Interference
Abstract Early signs of age-related cognitive decline are associated with deficits in novelty processing. Older individuals often mistake new events for familiar ones. This bias fo...
Nanofiber Patch with Gradient Presentation of Biomolecules for Treatment of Pediatric Tracheal Stenosis
PROJECT SUMMARY The long-term objective of this application is to bring a trachea patch to the market for treatment of pediatric tracheal stenosis, or narrowing of the airway, whic...
Mitochondria-targeted therapy to improve metabolic health post-menopause
SUMMARY Mitochondrial dysfunction in post-menopausal women due to loss of estradiol (E2) alone or in combination with age-induced accumulation of reactive oxygen species (ROS) may...
Analytical Infrastructure for Multiple Sample Single Cell Genomic Data
Project Summary Single cell genomic technologies are fast evolving technologies capable of measuring a variety of omics data modalities in individual cells. With a wide range of ap...
Dopamine and sensorimotor function in stuttering
Stuttering is a disorder of speech fluency that affects 3.5 million people in the USA alone. The primary symptoms consist of involuntary repetitions and prolongations of speech sou...
Engineering biomimetic 3D printed urethral tissue constructs using elastin-based bioinks for urethroplasty
Project Summary Urethral defects requiring urethroplasty occur in children and adults secondary to congenital, traumatic, infectious, and malignant conditions. Current tissue sourc...
Fast Multi-Functional 3D Imaging of Cellular Activities in Deep Tissue
PROJECT SUMMARY We propose to develop and disseminate an advanced 2p Bessel beam light sheet (2pBLS) microscopy instrument for high-speed sub-micron-resolution volumetric imaging i...
Precision HIV Prevention: Piloting a youth learning health community
Despite the substantial declines in HIV transmission achieved over the past decade, the full benefits of available tools and interventions have yet to be realized in youth. This di...
Virtual Digital Histopathology with Explainable Deep Learning for Prostate Cancer Diagnosis
Project Summary Adoption of digital histopathology has increased demands for gigapixel image analysis tools and methods for clinical applications. Integration of deep learning algo...
High-dimensional Mediation Analysis of Cardiovascular Traits with Multi-omics Data
Abstract Cardiovascular disease (CVD), including coronary heart disease (CHD) and stroke, is the leading cause of mortality and morbidity in both men and women in the US. Well-esta...
Targeting Dysregulated Maturation Program in PSC-Cardiomyocytes
Pluripotent-derived cardiomyocytes (PSC-CMs) remain immature in phenotype and function, and the lack of maturity has now emerged as a major concern in their clinical application. H...
Estimating the direct and indirect effects of a status-neutral person-centric intervention on HIV transmission among PWID in India
7. PROJECT SUMMARY / ABSTRACT Given the complex socio-structural barriers that PWID face, models of care need to shift from disease-centric models to status-neutral person-centric...
Airway inflammation and fear: elucidating immune mediators and neural substrates
PROJECT SUMMARY: Fear regulation is essential for optimal mental health. Maladaptive fear is a hallmark of posttraumatic stress disorder (PTSD), a debilitating condition afflicting...
Optimism and Dementia-Related Health Outcomes
ABSTRACT Substantial research demonstrates dispositional optimism is related to reduced mortality; fewer studies evaluate optimism specifically in relation to cognitive health - de...
The role of hexokinase 2 in liver fibrosis and NASH-induced HCC
Hepatic fibrosis is a major cause of mortality in patients with non-alcoholic steatohepatitis (NASH). Hepatic fibrosis also plays a major role in the development of hepatocellular...
Exploring the role of Imidazole Propionate on Alzheimer’s Disease and Related Dementias
Project Summary: Alzheimer's Disease (AD) and AD Related Dementias (ADRD) continue to present serious challenges in the aging population and there is a significant need to ide...