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99,167 grants found
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Integrated single cell and spatial mapping of habenula circuitry to identify projection-specific molecular pathways associated with opioid exposure.
PROJECT SUMMARY The national opioid epidemic is a significant public health crisis requiring accelerated efforts to translate mechanistic studies into therapeutic developments. Sub...
Metabolism and Epigenetic Regulation are Couples in Transdifferentiation and Vascular Regeneration
Abstract We discovered that nuclear reprogramming of somatic cells to a different somatic cell lineage, or induced pluripotent stem cells, requires activation of inflammatory signa...
The Effects of Cannabidiol on the Driving Performance of Healthy Adults
PROJECT SUMMARY Cannabidiol (CBD) is now a legal, widely consumed, substance in the United States, but research regarding CBD’s effects in healthy populations remains sparse. Altho...
Impact of Advanced Imaging and Enhanced Risk Profiling on Mitral Valve Prolapse
SUMMARY: Mitral valve prolapse (MVP) is a common cardiac condition that is frequently associated with trace to mild mitral regurgitation, is usually asymptomatic, and most often ig...
The impact of inherited and modifiable risk factors on clonal hematopoiesis and age-related disease
ABSTRACT The goal of this proposal is to improve our understanding of the factors that drive clonal hematopoiesis (CH) evolution to prevent CH-related adverse outcomes and promote...
Developing novel PET radioligands to image GPR39 in Alzheimer's Disease
Abstract GPR39 is a G-protein coupled receptor (GPCR) activated by zinc (Zn2+) and implicated in several neurodegenerative symptoms of Alzheimer’s disease (AD), including dyshomeos...
Leading NCI Clinical Trials Network research nationally and at the City of Hope Comprehensive Cancer Center
PROJECT SUMMARY This R50 application will support the activities of Dr. Alex Herrera as a Research Specialist (Clinician Scientist) promoting and supporting National Cancer Institu...
Subtyping COre for Research on the Etiology of Type 2 Diabetes (SCORE-T2D)
PROJECT SUMMARY Type 2 diabetes (T2D) is one of the fastest growing chronic diseases worldwide and is a leading contributor to comorbidities and early mortality. Current prevention...
Understanding and Designing pH-Responsive Peptides in Confined Nanoscale Environments
Project Summary: The confinement, localization, and nanoscale organization of biomolecules can dramatically alter their biochemical and physiological properties creating opportunit...
GEneration and assessment of Multi-omic informed Subtypes of Type 2 Diabetes in Diverse Populations (GEMS-T2D)
Type 2 diabetes (T2D) represents one of the biggest global health problems of the 21st century. Defined by the presence of hyperglycemia without another attributable cause, T2D is...
Mapping Airway Epithelial Cell-Immune Cell Interactions in Lung Health and Disease
Project Summary Asthma and chronic obstructive pulmonary disease (COPD) are inflammatory diseases that affect the airways and, together, are the largest causes of disability and mo...
Investigating the role of helix-1 in the fibrillization of SAA1-76
PROJECT SUMMARY/ABSTRACT AA amyloidosis is a severe complication of chronic inflammatory disorders and is potentially fatal. The amyloid fibrils involved in AA amyloidosis are deri...
Secondary Analysis of Existing Datasets to Define the Neutrophil Transcriptomic Response to Parenchymal Damage
PROJECT SUMMARY/ABSTRACT Background: Multiple organ failure is associated with a persistent systemic inflammatory response. Neutrophils, the most abundant leukocytes in blood, are...
The direct transcriptional regulation of cell cycle genes by cell identity factors during myeloid differentiation
Summary During blood development, most stem cells are quiescent, enter the cell cycle infrequently to amplify as short-term hematopoietic stem cells and lineage-restricted progenit...
Longitudinal omics-based trajectories of type 2 diabetes subtypes: the T2D Heterogeneity Consortium
PROJECT SUMMARY/ABSTRACT Millions of Americans are at risk of type 2 diabetes, but we lack a precise understanding of mechanisms causing high blood glucose levels, life-altering co...
Development and Validation of Remaining Measures to Assess the Bystander Intervention for Problematic Alcohol Use Model (BIPAUM)
Problematic alcohol use (PAU) is a common, yet serious, health issue among college students that can lead to negative outcomes such as assault, alcohol use disorders and even death...
Pharmacologically tuning membrane permeability to drug-sized organic cations through activation of KCa3.1 channels
PROJECT SUMMARY/ABSTRACT To reach their therapeutic targets within the body, most drugs need to have the ability to enter cells and traverse epithelial barriers. Achieving this hin...
KATP: DYNAMICS OF A CHANNEL-ENZYME COMPLEX
PROJECT SUMMARY ATP-sensitive K+ channels (KATP) couple a cell’s metabolic state to its electrical excitability. This process is crucial in pancreatic β-cells where KATP couples gl...
Development of Tailored, Multilevel Cervical Cancer Interventions for Ethnically Diverse Black Women
PROJECT SUMMARY While approximately 85% of Black women report being screened for Cervical Cancer (CC) compared with about 83% of White women, Black women have a higher incidence of...
Engineering and Characterization of pH dependent Antibodies
Project Summary Engineering and Characterization of pH dependent Antibodies Antibody-antigen interactions have served as a prototypical model for better understanding protein-prote...